{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:24:33Z","timestamp":1787268273662,"version":"build-2736575974"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to identify demographic, clinical, and operative factors of unplanned 30-day readmission following endoscopic transsphenoidal surgery (ETS).<\/jats:p>\n                  <jats:p>Single-center retrospective study.<\/jats:p>\n                  <jats:p>A tertiary academic medical center based in New York, NY.<\/jats:p>\n                  <jats:p>A total of 386 adult patients who underwent non-emergent ETS for pituitary adenomas between March 2009 and May 2020.<\/jats:p>\n                  <jats:p>The primary outcome was 30-day unplanned hospital admission. Clinical and demographic characteristics were analyzed using \u03c72 and Student's t-tests. For factors with p-value &lt;0.1, multivariate logistic regression models were constructed to estimate the adjusted odds of 30-day readmission across predictive factors.<\/jats:p>\n                  <jats:p>Of 386 patients who received ETS, 29 (7.5%) patients required readmission within 30 days of discharge. Eleven (2.8%) patients were readmitted for complications related to electrolyte derangements (syndrome of inappropriate antidiuretic hormone, hyponatremia), followed by 5 (1.3%) patients with epistaxis. On multivariate analysis, pituitary microadenomas (p\u2009=\u20090.032), transient diabetes insipidus (DI; p\u2009=\u20090.021), and preoperative visual cranial nerve palsies (CN III\/IV\/VI; p\u2009=\u20090.019) were associated with increased odds of 30-day readmission.<\/jats:p>\n                  <jats:p>Patients with pituitary microadenomas, transient DI, and preoperative cranial nerve palsies were at an increased risk for unplanned 30-day readmission after ETS. Dedicated neuroendocrinology involvement is necessary in the postoperative period to reduce readmission risk in these patients. Identification and careful monitoring of these at-risk populations is necessary, as targeted postdischarge care may prevent readmission and improve both patient and hospital outcomes.<\/jats:p>","DOI":"10.1055\/a-2717-2962","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T23:09:15Z","timestamp":1759878555000},"page":"572-576","source":"Crossref","is-referenced-by-count":1,"title":["Factors Associated with 30-Day Readmission after Endoscopic Transsphenoidal Surgery: The Critical Role of Dedicated Endocrinology Discharge Coordination"],"prefix":"10.1055","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-9573","authenticated-orcid":false,"given":"Alex","family":"Devarajan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, United 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States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Schupper","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Rutland","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, New York, United 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Ezzat","year":"2004","journal-title":"Cancer"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ecl.2020.04.002","article-title":"The epidemiology of pituitary adenomas","volume":"49","author":"A F Daly","year":"2020","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"E18","DOI":"10.3171\/2011.9.FOCUS11217","article-title":"Incidental pituitary adenomas","volume":"31","author":"W Sivakumar","year":"2011","journal-title":"Neurosurg Focus"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.ghir.2005.06.008","article-title":"Neurosurgical approach to treating pituitary adenomas","volume":"15","author":"E R Laws","year":"2005","journal-title":"Growth Horm IGF Res"},{"issue":"06","key":"ref5","first-page":"651","article-title":"The surgical management of pituitary adenomas in a series of 3,093 patients","volume":"193","author":"J A Jane 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Part 2: Selective medial wall resection in 50 pituitary adenoma patients","volume":"131","author":"S Cohen-Cohen","year":"2018","journal-title":"J Neurosurg"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1038\/s41598-022-12980-1","article-title":"Prospective intraoperative and histologic evaluation of cavernous sinus medial wall invasion by pituitary adenomas and its implications for acromegaly remission outcomes","volume":"12","author":"A Mohyeldin","year":"2022","journal-title":"Sci Rep"},{"issue":"06","key":"ref27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1210\/endrev\/bnac010","article-title":"Clinical biology of the pituitary adenoma","volume":"43","author":"S Melmed","year":"2022","journal-title":"Endocr Rev"},{"key":"ref28","first-page":"93","article-title":"Non-functioning pituitary adenomas","volume":"28","author":"P Chanson","year":"2005","journal-title":"J Endocrinol 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Nayak","year":"2018","journal-title":"J Endocr Soc"},{"issue":"03","key":"ref38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3171\/2021.11.JNS211260","article-title":"Identifying risk factors for postoperative diabetes insipidus in more than 2500 patients undergoing transsphenoidal surgery: a single-institution experience","volume":"137","author":"R S Joshi","year":"2022","journal-title":"J Neurosurg"},{"issue":"06","key":"ref39","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1210\/endo-20-6-762","article-title":"The effect of interruption of the supraopticohypophyseal tracts on the antidiuretic, pressor and oxytocic activity of the posterior lobe of the hypophysis","volume":"20","author":"C Fisher","year":"1936","journal-title":"Endocrinology"},{"issue":"04","key":"ref40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3171\/jns.1997.87.4.0499","article-title":"Pathophysiology of hyponatremia after transsphenoidal pituitary surgery","volume":"87","author":"B R Olson","year":"1997","journal-title":"J Neurosurg"},{"issue":"04","key":"ref41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.nec.2012.06.001","article-title":"Hypopituitarism and central diabetes insipidus: perioperative diagnosis and management","volume":"23","author":"J K Devin","year":"2012","journal-title":"Neurosurg Clin N Am"},{"issue":"04","key":"ref42","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s10143-019-01132-1","article-title":"Perioperative multidisciplinary management of endoscopic transsphenoidal surgery for sellar lesions: Practical suggestions from the Padova model","volume":"43","author":"M Barbot","year":"2020","journal-title":"Neurosurg Rev"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jocn.2017.07.012","article-title":"Reconstructive outcome of intraoperative cerebrospinal fluid leak after endoscopic endonasal surgery for tumors involving skull 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