{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:47:05Z","timestamp":1789001225571,"version":"build-2803163510"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"12","funder":[{"DOI":"10.13039\/501100024679","name":"Advanz Pharma","doi-asserted-by":"crossref","award":["The grant was dedicated to T.B."],"award-info":[{"award-number":["The grant was dedicated to T.B."]}],"id":[{"id":"10.13039\/501100024679","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Guidelines on primary biliary cholangitis (PBC) recommend therapy with 13\u201315 mg\/kg ursodeoxycholic acid (UDCA) and assessment of treatment response after 12 months. We evaluated to which extent these recommendations are followed in newly diagnosed patients.<\/jats:p>\n                  <jats:p>The German PBC Registry recruited three subgroups: Adequate or inadequate UDCA treatment responders (Paris II criteria) and newly diagnosed patients (&lt;6 months prior to recruitment). We focus on newly diagnosed patients with UDCA monotherapy.<\/jats:p>\n                  <jats:p>82 patients were recruited (43 at 12 tertiary and 39 at 9 secondary centers) thereof 22% with cirrhosis. Individuals with cirrhosis were older (71 \u00b1 9 vs. 55 \u00b1 14 years, p&lt;0.001) and presented more frequently with diabetes mellitus (44% vs. 13%, p=0.0054) and arterial hypertension (78% vs. 42%, p=0.0076) compared to cases without cirrhosis.<\/jats:p>\n                  <jats:p>12 months follow-up data were available in 62 patients. UDCA underdosing (&lt;13 mg\/kg\/d) occurred in 47% and 74% of cases (p=0.013) at tertiary and secondary care at treatment initiation and in 29% and 73% (p=0.002) after 12 months, respectively. Paris II criteria were achieved in 74% and a deep UDCA response (alkaline phosphatase &lt; ULN and bilirubin &lt; 0.6 \u00d7 ULN) in 32% of cases.<\/jats:p>\n                  <jats:p>Newly diagnosed PBC patients include a substantial proportion of late presenters with cirrhosis. UDCA dosage is suboptimal in many cases. Time point of diagnosis and UDCA dosage should be improved.<\/jats:p>","DOI":"10.1055\/a-2721-1160","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T23:50:31Z","timestamp":1765324231000},"page":"1260-1267","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics of newly diagnosed patients with primary biliary cholangitis (PBC) indicate the need for better awareness on timely diagnosis and adequate UDCA therapy"],"prefix":"10.1055","volume":"63","author":[{"given":"Kerstin","family":"Stein","sequence":"first","affiliation":[{"name":"Practice of Hepatology Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf P.","family":"Hofmann","sequence":"first","affiliation":[{"name":"Gastroenterology at Bayerischer Platz, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Franke","sequence":"additional","affiliation":[{"name":"Clinical Trial Centre of Medical Faculty, University of Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Petroff","sequence":"additional","affiliation":[{"name":"Clinical Trial Centre of Medical Faculty, University of Leipzig, Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charit\u00e9 Mitte (CCM), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Bantel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Division of Hepatology\/Transplant Hepatology, Department of Medicine I, Universit\u00e4tsklinikum Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Denk","sequence":"additional","affiliation":[{"name":"Department of Medicine II and Transplantation Center, University Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7696-475X","authenticated-orcid":false,"given":"Philipp A.","family":"Reuken","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV (Gastroenterology, Hepatology, Infectious Diseases), University Hospital Jena, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn M.","family":"Schattenberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Saarland University Medical Center, Homburg, Germany"},{"name":"Department of Medicine I, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Naumann","sequence":"additional","affiliation":[{"name":"UBN Private Practice, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"B\u00f6ttler","sequence":"additional","affiliation":[{"name":"Department of Medicine II, University Hospital Freiburg, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 6 Gastroenterology, Hepatology, Endocrinology, Paracelsus Medical University, Hospital Nuremberg, Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Goethe University, University Hospital, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hinz","sequence":"additional","affiliation":[{"name":"Private Practice for Gastroenterology Herne, Herne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Greinert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Halle, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Berg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thadd\u00e4us Till","family":"Wissniowski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Klinikum Chemnitz gGmbH, Chemnitz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Georg","family":"Simon","sequence":"additional","affiliation":[{"name":"Practice for Gastroenterology, Leverkusen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7028-3881","authenticated-orcid":false,"given":"Jonel","family":"Trebicka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger","family":"Behrens","sequence":"additional","affiliation":[{"name":"Private Practice Halle, Halle, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Gr\u00fcmmer","sequence":"additional","affiliation":[{"name":"Practice of 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