{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:36:36Z","timestamp":1779212196122,"version":"3.51.4"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The triglyceride-glucose index, an indicator of insulin resistance, has emerged\n                    as a potential predictor of various cardiovascular diseases. However, the\n                    association between the triglyceride-glucose index and peripheral artery disease\n                    remains unclear. This meta-analysis sought to clarify the relationship between\n                    the triglyceride-glucose index and the incidence or prevalence of peripheral\n                    artery disease. A comprehensive search of the PubMed, Embase, and Web of Science\n                    databases was carried out to identify relevant observational studies published\n                    up to June 1, 2024. Inclusion criteria included studies on adult populations\n                    that evaluated the triglyceride-glucose index and reported peripheral artery\n                    disease outcomes. To assess the association between the triglyceride-glucose\n                    index and peripheral artery disease, risk ratios and 95% confidence intervals\n                    were computed using a random-effects model incorporating the impact of\n                    heterogeneity. Nine studies with a total of 37,761 participants were involved in\n                    the meta-analysis. The analysis revealed that individuals with a high\n                    triglyceride-glucose index had significantly increased odds of peripheral artery\n                    disease (risk ratio: 1.42, 95% confidence interval: 1.21\u20131.67, p &lt;\n                    0.001; I\n               2=55%). Sensitivity analyses performed by excluding\n                    one study at a time confirmed the robustness of these findings. Subgroup\n                    analyses demonstrated consistent associations across different study designs,\n                    populations, and methodological quality. Diabetic patients exhibited a stronger\n                    association (risk ratio: 1.38) compared to non-diabetic participants (risk\n                    ratio: 1.06, p\n               subgroup difference=0.006). In conclusion, a\n                    high triglyceride-glucose index is linked to peripheral artery disease,\n                    especially in people with diabetes. These results suggest that the\n                    triglyceride-glucose index could be used as a valuable marker for assessing\n                    peripheral artery disease risk in clinical practice.<\/jats:p>","DOI":"10.1055\/a-2722-1508","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T23:02:38Z","timestamp":1760396558000},"page":"572-582","source":"Crossref","is-referenced-by-count":1,"title":["Association Between the Triglyceride-Glucose Index and Peripheral\n                    Artery Disease: A Meta-Analysis"],"prefix":"10.1055","volume":"57","author":[{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu\n                    Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Information Center, Beijing Institute of Geriatrics,\n                    Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Lu","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Information Center, Beijing Institute of Geriatrics,\n                    Xuanwu Hospital of Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"afae114","DOI":"10.1093\/ageing\/afae114","article-title":"New horizons in peripheral artery disease","volume":"53","author":"JS M Houghton","year":"2024","journal-title":"Age Ageing"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/FJC.0000000000001556","article-title":"A practical guide to understanding and treating peripheral artery disease","volume":"83","author":"M R Chilbert","year":"2024","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/j.jvs.2020.09.039","article-title":"A systematic review and meta-analysis of gender differences in long-term\n                    mortality and cardiovascular events in peripheral artery disease","volume":"73","author":"S L Parvar","year":"2021","journal-title":"J Vasc Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrendo.2014.29","article-title":"Insulin resistance and hyperglycaemia in cardiovascular disease development","volume":"10","author":"M Laakso","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4239\/wjd.v10.i2.63","article-title":"Insulin resistance is associated with subclinical vascular disease in\n                    humans","volume":"10","author":"M M Adeva-Andany","year":"2019","journal-title":"World J Diabetes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12933-018-0762-4","article-title":"Association between insulin resistance and the development of cardiovascular\n                    disease","volume":"17","author":"V Ormazabal","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"154766","DOI":"10.1016\/j.metabol.2021.154766","article-title":"Insulin resistance, cardiovascular stiffening and cardiovascular disease","volume":"119","author":"M A Hill","year":"2021","journal-title":"Metabolism"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5507\/bp.2019.021","article-title":"Indirect insulin resistance detection: Current clinical trends and laboratory\n                    limitations","volume":"163","author":"S Placzkowska","year":"2019","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"102581","DOI":"10.1016\/j.dsx.2022.102581","article-title":"Challenges in the diagnosis of insulin resistance: Focusing on the role of\n                    HOMA-IR and Tryglyceride\/glucose index","volume":"16","author":"D L Tahapary","year":"2022","journal-title":"Diabetes Metab Syndr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin\n                    sensitivity. 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2722-1508.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T23:48:48Z","timestamp":1763423328000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2722-1508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,11,17]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2722-1508","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10,13]]},"published":{"date-parts":[[2025,10]]}}}