{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:35:13Z","timestamp":1777073713651,"version":"3.51.4"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vascular Ehlers\u2013Danlos syndrome (vEDS) is a rare inherited connective tissue disorder associated with significant maternal morbidity and mortality during pregnancy. Conflicting recommendations exist for management, particularly in patients with variant of uncertain significance (VUS).<\/jats:p>\n                  <jats:p>We present a 39-year-old G2P1011 with a strong family history suggestive of vEDS who experienced an uncomplicated vaginal delivery followed by a large retroperitoneal hematoma requiring interventional radiology embolization and intensive care management for a postprocedural femoral pseudoaneurysm.<\/jats:p>\n                  <jats:p>Postpartum genetic testing revealed a heterozygous VUS in COL3A1 (c.1297G&gt;A [p.Glu433Lys]).<\/jats:p>\n                  <jats:p>This case illustrates the challenges of counseling and managing pregnancy in patients with suspected vEDS and VUS, highlighting the importance of risk mitigation strategies, multidisciplinary care, and nuanced interpretation of genetic results.<\/jats:p>","DOI":"10.1055\/a-2722-8222","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T23:45:30Z","timestamp":1761954330000},"page":"1003-1006","source":"Crossref","is-referenced-by-count":0,"title":["Postpartum Presentation of a Variant of Uncertain Significance in COL3A1: A Case Report"],"prefix":"10.1055","volume":"43","author":[{"given":"Fatima Zohra","family":"Khamissi","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Bachur","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin, United 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