{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:11:18Z","timestamp":1778227878920,"version":"3.51.4"},"reference-count":5,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Ein 56-j\u00e4hriger Mann stellte sich mit lumbalen Schmerzen vor, die in das linke Bein ausstrahlten.<\/jats:p>\n                  <jats:p>Die CT der Lendenwirbels\u00e4ule zeigte eine verminderte H\u00f6he der Bandscheibenr\u00e4ume und ein Vakuumph\u00e4nomen. Die MRT offenbarte einen linksseitigen Bandscheibenvorfall auf H\u00f6he L3\u2013L4 als Ursache der Beschwerden. Intraoperativ zeigte das Bandscheibenmaterial eine ungew\u00f6hnlich dunkle Pigmentierung.<\/jats:p>\n                  <jats:p>Histologisch wurden ochronotische Pigmenteinlagerungen nachgewiesen, wodurch die Diagnose einer Alkaptonurie (AKU) gestellt wurde.<\/jats:p>\n                  <jats:p>Der Eingriff wurde regul\u00e4r beendet. Postoperativ erfolgte die Empfehlung zur internistischen Abkl\u00e4rung und genetischen Beratung.<\/jats:p>\n                  <jats:p>Bei atypisch pigmentiertem Gewebe sollten Chirurg*innen seltene Stoffwechselerkrankungen wie AKU in Betracht ziehen, um eine fr\u00fchzeitige Diagnosestellung und eine gezielte Langzeitbetreuung zu erm\u00f6glichen.<\/jats:p>","DOI":"10.1055\/a-2723-2603","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T23:38:59Z","timestamp":1768952339000},"page":"111-114","source":"Crossref","is-referenced-by-count":0,"title":["Intraoperative Diagnose einer Alkaptonurie bei lumbaler Bandscheibenoperation: Ein Fallbericht"],"prefix":"10.1055","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-6332","authenticated-orcid":false,"given":"Murat","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Kayseri City Hospital: Kayseri Sehir Egitim ve Arastirma Hastanesi, Kayseri, TURKEY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"\u00c7evik Kaya","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Pathologie, Bildungs- und Forschungskrankenhaus Kayseri,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcmit","family":"Zeydo\u011flu","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurochirurgie, Bildungs- und Forschungskrankenhaus Kayseri,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"issue":"26","key":"ref1","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1056\/NEJMoa021736","article-title":"Natural history of alkaptonuria","volume":"347","author":"C Phornphutkul","year":"2002","journal-title":"N Engl J Med"},{"issue":"06","key":"ref2","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s10545-011-9363-z","article-title":"An update on molecular genetics of Alkaptonuria (AKU)","volume":"34","author":"A Zatkova","year":"2011","journal-title":"J Inherit Metab Dis"},{"issue":"02","key":"ref3","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1136\/annrheumdis-2014-206033","article-title":"SONIA 1 study","volume":"75","author":"LR Ranganath","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"20","key":"ref4","first-page":"E478","article-title":"Ochronosis of the spine","volume":"27","author":"MM Thacker","year":"2002","journal-title":"Spine"},{"issue":"03","key":"ref5","first-page":"E76","article-title":"Surgical management of alkaptonuria","volume":"45","author":"JA Gil","year":"2016","journal-title":"Am J Orthop"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2723-2603.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:23:47Z","timestamp":1778225027000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2723-2603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":5,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,1,20]]},"published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2723-2603","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]}}}