{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:50:27Z","timestamp":1783680627465,"version":"3.55.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"07\/08","funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und\nForschung","doi-asserted-by":"crossref","award":["#01KG2210"],"award-info":[{"award-number":["#01KG2210"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die Prim\u00e4r Progrediente Aphasie (PPA) ist eine neurodegenerative Erkrankung,\ndie zu fortschreitenden Sprach- und Kommunikationsst\u00f6rungen mit gravierenden\nAuswirkungen auf den Alltag der Betroffenen f\u00fchrt.<\/jats:p>\n                  <jats:p>Im Rahmen einer internationalen Forschungskooperation\n(https:\/\/www.comet-initiative.org\/Studies\/Details\/1871) wurden wichtige\nEndpunkte zur Erfassung des (Sprach-)Therapieerfolgs bei Menschen mit PPA\nerarbeitet (Core Outcome Set f\u00fcr PPA, COS-PPA). Hier berichten wir \u00fcber die\nErgebnisse aus Deutschland, diskutieren sie im Kontext des Gesamtprojekts\nund vergleichen sie mit relevanten Endpunkten bei Aphasie nach\nSchlaganfall.<\/jats:p>\n                  <jats:p>Es wurden mit n=9 PPA-Patient:innen und n=13 Angeh\u00f6rigen sechs\nKleingruppeninterviews mit der Nominellen Gruppentechnik durchgef\u00fchrt, um\nW\u00fcnsche und Ziele bzgl. Kommunikation und Sprachtherapie sowie ihre\nWichtigkeit zu erfragen.<\/jats:p>\n                  <jats:p>Die PPA-Patient:innen betonten sprachliche Ziele, w\u00e4hrend die Angeh\u00f6rigen\nSchwerpunkte bzgl. alltagsrelevanter Kommunikation und psychologischer\nAspekte setzten. Die globalen COS-PPA-Ergebnisse waren weitgehend konsistent\nmit den Befunden in Deutschland und es wurde ebenfalls ein Fokus auf Sprache\nund Kommunikation gelegt. F\u00fcr den Vergleich der deutschen\nBefragungsergebnisse mit dem COS f\u00fcr Aphasie nach Schlaganfall zeigten sich\nv.a. \u00dcberschneidungen hinsichtlich der Verbesserung von Sprache,\nKommunikation und Lebensqualit\u00e4t.<\/jats:p>\n                  <jats:p>Die dargestellten W\u00fcnsche und Ziele bei PPA sowie die Entwicklung eines\nCOS-PPA k\u00f6nnen zur Therapieplanung und zur Vereinheitlichung von\nForschungsmethoden in klinischen Studien beitragen. Der individuelle\nCharakter der Behandlung sollte dabei erhalten bleiben.<\/jats:p>","DOI":"10.1055\/a-2723-6584","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T23:39:32Z","timestamp":1768520372000},"page":"266-273","source":"Crossref","is-referenced-by-count":1,"title":["Was sind wichtige Ziele bei der Behandlung von Menschen mit Prim\u00e4r\nProgredienter Aphasie?"],"prefix":"10.1055","volume":"94","author":[{"given":"Nina","family":"Unger","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie,\nUniversit\u00e4tsmedizin Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina J.","family":"Molt","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie,\nUniversit\u00e4tsmedizin Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea K.","family":"Heidelmann","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie,\nUniversit\u00e4tsmedizin Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna U.","family":"Rysop","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie,\nUniversit\u00e4tsmedizin Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Volkmer","sequence":"additional","affiliation":[{"name":"Dementia Research Centre, UCL Queen Square Institute of\nNeurology, University College London, London, United Kingdom"},{"name":"Psychology and Language Sciences (PALS), University\nCollege London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Fl\u00f6el","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie,\nUniversit\u00e4tsmedizin Greifswald, Greifswald, Germany"},{"name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen\nStandort Rostock\/Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Meinzer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie,\nUniversit\u00e4tsmedizin Greifswald, Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/02687038.2019.1568135","article-title":"Quality of life in primary progressive aphasia: What do we know and what can we\ndo next?","volume":"33","author":"L Ruggero","year":"2019","journal-title":"Aphasiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1212\/01.wnl.0000175982.57472.84","article-title":"Natural history of primary progressive aphasia","volume":"65","author":"E Le Rhun","year":"2005","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"M L Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ncl.2017.01.008","article-title":"Frontotemporal dementia","volume":"35","author":"N T Olney","year":"2017","journal-title":"Neurol Clin"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1177\/1471301217699675","article-title":"Development of a psycho-educational support program for individuals with primary\nprogressive aphasia and their care-partners","volume":"18","author":"D J Morhardt","year":"2019","journal-title":"Dementia"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/practneurol-2018-001921","article-title":"Speech and language therapy approaches to managing primary progressive\naphasia","volume":"20","author":"A Volkmer","year":"2020","journal-title":"Pract Neurol"},{"key":"ref8","first-page":"CD015067","article-title":"Non-pharmacological interventions for improving language and communication in\npeople with primary progressive aphasia","volume":"5","author":"M Roheger","year":"2024","journal-title":"Cochrane Database Syst Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/1747493018806200","article-title":"A core outcome set for aphasia treatment research: The ROMA consensus\nstatement","volume":"14","author":"S J Wallace","year":"2019","journal-title":"Int J Stroke"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/1460-6984.12840","article-title":"Measuring communication as a core outcome in aphasia trials: Results of the\nROMA-2 international core outcome set development meeting","volume":"58","author":"S J Wallace","year":"2023","journal-title":"Int J Lang Commun Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1080\/02687038.2017.1417539","article-title":"Top 10 research priorities relating to aphasia following stroke","volume":"32","author":"S Franklin","year":"2018","journal-title":"Aphasiology"},{"key":"ref13","volume-title":"Western Aphasia Battery \u2013 Revised (WAB-R)","author":"A Kertesz","year":"2006"},{"key":"ref14","volume-title":"A user\u2019s guide to the General Health Questionnaire","author":"D Goldberg","year":"1988"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1177\/0269215508101729","article-title":"Psychometric properties of the Stroke and Aphasia Quality of Life Scale\n(SAQOL-39) in a generic stroke population","volume":"23","author":"K Hilari","year":"2009","journal-title":"Clin Rehabil"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3109\/13682820903111952","article-title":"Measuring verbal and non-verbal communication in aphasia: Reliability, validity,\nand sensitivity to change of The Scenario Test","volume":"45","author":"I Van der Meulen","year":"2010","journal-title":"Int J Lang Commun Disord"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e078714","DOI":"10.1136\/bmjopen-2023-078714","article-title":"COS-PPA: Protocol to develop a core outcome set for primary progressive\naphasia","volume":"14","author":"A Volkmer","year":"2024","journal-title":"BMJ Open"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1080\/09638288.2016.1194899","article-title":"Which outcomes are most important to people with aphasia and their families? An\ninternational nominal group technique study framed within the ICF","volume":"39","author":"S J Wallace","year":"2017","journal-title":"Disabil Rehabil"},{"key":"ref21","first-page":"40","volume-title":"The FACS of life ASHA facs \u2013 a functional outcome measure for\nadults","author":"CM Frattali","year":"1995"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/02687030802453202","article-title":"Putting the CAT out: What the Comprehensive Aphasia Test has to offer","volume":"24","author":"D Howard","year":"2009","journal-title":"Aphasiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1080\/02687038.2014.904497","article-title":"Long-term follow-up in primary progressive aphasia: Clinical course and health\ncare utilisation","volume":"28","author":"L Riedl","year":"2014","journal-title":"Aphasiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/02687030701282595","article-title":"Counting what counts: A framework for capturing real-life outcomes of aphasia\nintervention","volume":"22","author":"A Kagan","year":"2008","journal-title":"Aphasiology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/alz.13415","article-title":"Symptom-led staging for semantic and non-fluent\/agrammatic variants of primary\nprogressive aphasia","volume":"20","author":"CJ D Hardy","year":"2024","journal-title":"Alzheimers Dement"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780192630346.001.0001","volume-title":"Early onset dementia: A multidisciplinary approach","author":"J R Hodges","year":"2001"}],"container-title":["Fortschritte der Neurologie \u00b7 Psychiatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2723-6584.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:32:24Z","timestamp":1783636344000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2723-6584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":22,"journal-issue":{"issue":"07\/08","published-online":{"date-parts":[[2026,7,9]]},"published-print":{"date-parts":[[2026,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2723-6584","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0720-4299","1439-3522"],"issn-type":[{"value":"0720-4299","type":"print"},{"value":"1439-3522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]}}}