{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:21:00Z","timestamp":1771305660132,"version":"3.50.1"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Das kolorektale Karzinom (KRK) z\u00e4hlt weltweit zu den h\u00e4ufigsten malignen Erkrankungen. Etwa 10% aller KRK sind monogen vererbt und werden unter dem Begriff der heredit\u00e4ren kolorektalen Karzinome (hKRK) zusammengefasst. Die steigende Anwendung molekularpathologischer Verfahren wie der Mikrosatellitenanalyse wird zuk\u00fcnftig zu einer deutlichen Zunahme der Diagnoserate f\u00fchren. Die wichtigsten hKRK lassen sich in Polyposis-Syndrome (z.\u00a0B. FAP, MAP) und Nicht-Polyposis-Syndrome (v.\u00a0a. Lynch-Syndrom) unterteilen. Die chirurgische Therapie ist dabei syndromspezifisch und erfordert eine individualisierte Abw\u00e4gung zwischen onkologischer Sicherheit und funktionellem Langzeitergebnis. Bei der FAP steht die rechtzeitige prophylaktische Kolektomie im Vordergrund, bei MAP richtet sich das operative Vorgehen nach Polypenlast und Primarius. F\u00fcr seltene Polyposis-Syndrome wie NTHL1-, POLE- oder POLD1-assoziierte Syndrome existieren bislang keine gesicherten Empfehlungen. Das Lynch-Syndrom\n      hingegen ist durch ein signifikant erh\u00f6htes Risiko f\u00fcr metachrone Tumoren gekennzeichnet. Hier m\u00fcssen chirurgische Strategien zunehmend unter Ber\u00fccksichtigung immunonkologischer Therapieoptionen (z.\u00a0B. Checkpoint-Inhibition bei MSI-Tumoren) neu bewertet werden. Die chirurgische Versorgung von Patient*innen mit hKRK sollte an spezialisierten Zentren erfolgen und eine genetische Beratung sowie eine interdisziplin\u00e4re Falldiskussion einschlie\u00dfen.<\/jats:p>","DOI":"10.1055\/a-2724-3658","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:38:48Z","timestamp":1762821528000},"page":"34-39","source":"Crossref","is-referenced-by-count":1,"title":["Chirurgische Therapie bei erblichen Tumorsyndromen des Kolorektums"],"prefix":"10.1055","volume":"151","author":[{"given":"Mona","family":"Bre\u00dfer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Allgemein-, Viszeral-, Thorax- und Gef\u00e4\u00dfchirurgie, Universit\u00e4tsklinikum Bonn, Bonn, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kr\u00f6plin","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Allgemein-, Viszeral-, Thorax- und 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