{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:52:35Z","timestamp":1777330355006,"version":"3.51.4"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Interventional therapies for hepatocellular carcinoma (HCC) include various methods such as transarterial chemoembolization (TACE), radiofrequency and microwave ablation (RFA, MWA), selective internal radiotherapy (SIRT), and stereotactic body radiation therapy (SBRT). Imaging follow-up using magnetic resonance imaging (MRI) is essential for the early detection of recurrence, but requires profound knowledge of therapy-related imaging changes.<\/jats:p>\n                  <jats:p>A structured PubMed literature search covering the period from 2000 to 2025 was conducted using the keywords \u201chepatocellular carcinoma,\u201d \u201cmagnetic resonance imaging,\u201d \u201cthermal ablation,\u201d \u201ctransarterial chemoembolization,\u201d \u201ctransarterial radioembolization,\u201d \u201cstereotactic body radiotherapy,\u201d and \u201ctreatment response.\u201d In addition, the study incorporated current national and international guidelines, as well as institutional clinical experience.<\/jats:p>\n                  <jats:p>Post-interventional imaging changes on MRI vary depending on the therapeutic approach applied. Typical morphological changes are observed immediately after thermoablation and TACE, whereas therapeutic effects of SIRT and SBRT become clearly evident only after weeks to months. Profound knowledge of standardized evaluation systems such as mRECIST, EASL, and LI-RADS-TR is crucial to ensure a precise and structured assessment of therapeutic response.<\/jats:p>\n                  <jats:p>Knowledge of specific MRI findings and standardized assessment systems is essential for structured follow-up of hepatocellular carcinoma after interventional therapy. Limitations arise from the heterogeneity of imaging findings, variable temporal patterns, and potential influences of combination therapies. Systemic therapies were not considered, restricting generalizability.<\/jats:p>","DOI":"10.1055\/a-2724-6488","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T23:51:32Z","timestamp":1763769092000},"page":"610-623","source":"Crossref","is-referenced-by-count":1,"title":["MRI after Interventional Therapy of Hepatocellular Carcinoma: Typical Changes over Time"],"prefix":"10.1055","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3450-7585","authenticated-orcid":false,"given":"Jens","family":"K\u00fcbler","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Ashkar","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz T.","family":"Winkelmann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cihan","family":"Gani","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Nikolaou","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Universit\u00e4tsklinikum T\u00fcbingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Universit\u00e4tsklinikum 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