{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:23:57Z","timestamp":1791307437746,"version":"4.3.1"},"reference-count":293,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rue (Ruta spp.) is a medicinal, ornamental, and culinary herb, distinguished by its strong repellent aroma, rich in various bioactive compounds. In addition to different traditional uses, rue shows anti-inflammatory, anticancer, antiviral, and antifungal properties. Thus, we aimed to comprehensively review the past and present roles of Ruta spp. in the management of diseases. Accordingly, we systematically reviewed PubMed, Web of Science, Scopus, and Cochrane Library with relevant keywords for ethnopharmacological, pharmacological, pre-clinical, clinical, and toxicological studies to evaluate the efficacy and safety of rue, in addition to its traditional applications. In traditional Indian and Persian Medicine, rue is mostly utilized for tonifying the stomach, managing neural complications, and regulating the menstrual cycle. Ethnopharmacological studies indicated that all parts of rue are used in more than 15 countries for different purposes such as for the\n          diseases of respiratory system, urinary system, gastrointestinal system, and nervous system. In preclinical studies, Ruta spp. are examined in the management of neurologic disorders, endocrine and metabolic disorders, gastrointestinal disorders, and neuropsychologic disorders. Human studies mainly included homeopathic formulations in musculoskeletal disorders, oncology, ophthalmology, obesity, and gynecology. Although Ruta spp. show antioxidant effects, their systemic toxicity, cytotoxicity, and photosensitivity effects may be related to the bioactive compounds such as xanthotoxin, psoralenes, and bergapten in high doses. In conclusion, in the usual dose that is used, rue showed the potential of managing different health problems; however, more clinical studies are required.<\/jats:p>","DOI":"10.1055\/a-2725-3868","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:37:01Z","timestamp":1762821421000},"page":"604-638","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Genus Ruta: Traditional Uses, Pharmacology, and Safety Concerns"],"prefix":"10.1055","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3880-8884","authenticated-orcid":false,"given":"Mohammad Sadegh","family":"Adel-Mehraban","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Traditional Persian Medicine and Complementary Medicine (PerCoMed) Student Association, Students\u02bc Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl Hakim","family":"Elahi","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6352-8916","authenticated-orcid":false,"given":"Niusha","family":"Esmaealzadeh","sequence":"additional","affiliation":[{"name":"Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Mirali","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-4041","authenticated-orcid":false,"given":"Syed Mohd Abbas","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Moalajat (Internal Medicine), Hakim Syed Ziaul Hasan Government Unani Medical College, Bhopal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-0546","authenticated-orcid":false,"given":"Roodabeh","family":"Bahramsoltani","sequence":"additional","affiliation":[{"name":"Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.jep.2007.12.013","article-title":"Continuity and change in the Mediterranean medical tradition: Ruta spp.(rutaceae) in Hippocratic 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