{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:48:12Z","timestamp":1790704092025,"version":"4.1.0"},"reference-count":400,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Traditionally, platelet function has been defined in the context of their role in hemostasis and thrombus formation. In recent years, however, the concept of platelet function has expanded, as emerging evidence supports that platelets\u2014despite their small size\u2014serve as versatile and potent modulators in a wide range of biological processes, including immune responses. In the neonatal period, the immune response is immature and particularly susceptible to dysregulation. The distinct properties of neonatal platelets, compared with those of adults, may influence both the sensitivity and the magnitude of the inflammatory response. The aim of this review is to summarize current knowledge regarding the involvement of platelets in neonatal sepsis, to highlight the immunological and molecular characteristics implicated in this process, and to identify research gaps that limit the use of platelets as diagnostic and therapeutic targets in this particularly vulnerable population.<\/jats:p>","DOI":"10.1055\/a-2731-2399","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:50:18Z","timestamp":1761609018000},"page":"692-722","source":"Crossref","is-referenced-by-count":4,"title":["Platelets in Neonatal Sepsis: Beyond Clotting, from Silent Players to Immune Orchestrators"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-8901","authenticated-orcid":false,"given":"Rozeta","family":"Sokou","sequence":"additional","affiliation":[{"name":"Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8588-8672","authenticated-orcid":false,"given":"Alexandra","family":"Lianou","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAghios Panteleimon\u201d General Hospital of Nikea, Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0759","authenticated-orcid":false,"given":"Andreas G.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit, \u201cAttikon\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Petrou","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit, \u201cAttikon\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-6579","authenticated-orcid":false,"given":"Stefanos","family":"Bonovas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Nikolopoulos","sequence":"additional","affiliation":[{"name":"Medical School, University of Cyprus, Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argirios E.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit, \u201cAttikon\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Iacovidou","sequence":"additional","affiliation":[{"name":"Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1001\/jamapediatrics.2017.5208","article-title":"Defining pediatric sepsis","volume":"172","author":"L J Schlapbach","year":"2018","journal-title":"JAMA Pediatr"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"M Singer","year":"2016","journal-title":"JAMA"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"R S Hotchkiss","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1586\/eri.12.50","article-title":"Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes","volume":"10","author":"G S Martin","year":"2012","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"GBD 2017 Causes of Death 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neonatal sepsis in sub-Saharan Africa","volume":"3","author":"S L Ranjeva","year":"2018","journal-title":"BMJ Glob Health"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"F547","DOI":"10.1136\/archdischild-2017-313203","article-title":"Epidemiology of UK neonatal infections: the neonIN infection surveillance network","volume":"103","author":"B Cailes","year":"2018","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1097\/CCM.0000000000000509","article-title":"Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis","volume":"42","author":"S L Weiss","year":"2014","journal-title":"Crit Care Med"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/cc12716","article-title":"Bench-to-bedside review: platelets and active immune functions - new clues for immunopathology?","volume":"17","author":"O Garraud","year":"2013","journal-title":"Crit Care"},{"issue":"18","key":"ref13","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood-2013-11-462432","article-title":"Emerging roles for platelets as immune and inflammatory cells","volume":"123","author":"C N Morrell","year":"2014","journal-title":"Blood"},{"issue":"04","key":"ref14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1160\/TH16-12-0921","article-title":"Small but mighty: platelets as central effectors of host defense","volume":"117","author":"T J Stocker","year":"2017","journal-title":"Thromb Haemost"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3389\/fimmu.2019.01687","article-title":"Platelets in sepsis: an update on experimental models and clinical data","volume":"10","author":"A Assinger","year":"2019","journal-title":"Front 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Haemost"},{"issue":"06","key":"ref32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-2007-996049","article-title":"Platelet function in the newborn","volume":"24","author":"A D Michelson","year":"1998","journal-title":"Semin Thromb Hemost"},{"issue":"06","key":"ref33","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1055\/s-0038-1648990","article-title":"Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood","volume":"72","author":"D Rajasekhar","year":"1994","journal-title":"Thromb Haemost"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/09537100400016862","article-title":"Neonatal platelets from cord blood and peripheral blood","volume":"16","author":"A G Sitaru","year":"2005","journal-title":"Platelets"},{"issue":"04","key":"ref35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1055\/s-2003-42587","article-title":"Neonatal platelet function","volume":"29","author":"S J Israels","year":"2003","journal-title":"Semin Thromb Hemost"},{"issue":"04","key":"ref36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1203\/00006450-199910000-00014","article-title":"Surface expression of major membrane glycoproteins on resting and TRAP-activated neonatal platelets","volume":"46","author":"J Sim\u00e1k","year":"1999","journal-title":"Pediatr Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.thromres.2023.03.005","article-title":"Platelet function in neonates and children","volume":"231","author":"S Van Den Helm","year":"2023","journal-title":"Thromb Res"},{"issue":"06","key":"ref38","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1055\/s-0038-1646924","article-title":"Significant hypo-responsiveness to GPVI and CLEC-2 agonists in pre-term and full-term neonatal platelets and following immune thrombocytopenia","volume":"118","author":"A T Hardy","year":"2018","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.thromres.2008.10.004","article-title":"The platelet hyporeactivity of extremely low birth weight neonates is age-dependent","volume":"124","author":"F J Bednarek","year":"2009","journal-title":"Thromb Res"},{"issue":"04","key":"ref40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/17474086.2017.1293518","article-title":"Platelet function testing in pediatric patients","volume":"10","author":"A M Hvas","year":"2017","journal-title":"Expert Rev Hematol"},{"issue":"06","key":"ref41","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/PCC.0000000000001122","article-title":"Three hypothetical inflammation pathobiology phenotypes and pediatric sepsis-induced multiple organ failure outcome","volume":"18","author":"J A Carcillo","year":"2017","journal-title":"Pediatr Crit Care Med"},{"issue":"02","key":"ref42","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0040-1715832","article-title":"A risk score for predicting the incidence of hemorrhage in critically ill neonates: development and validation study","volume":"121","author":"R Sokou","year":"2021","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref43","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00277-023-05144-2","article-title":"Neonatal hematological parameters: the translational aspect of developmental hematopoiesis","volume":"102","author":"R Sokou","year":"2023","journal-title":"Ann Hematol"},{"issue":"01","key":"ref44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2141.1999.01154.x","article-title":"Plasma thrombopoietin concentrations in thrombocytopenic and non-thrombocytopenic patients in a neonatal intensive care unit","volume":"104","author":"M C Sola","year":"1999","journal-title":"Br J Haematol"},{"issue":"03","key":"ref45","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1651-2227.1999.tb01107.x","article-title":"Circulating thrombopoietin levels in neonates with infection","volume":"88","author":"P Colarizi","year":"1999","journal-title":"Acta Paediatr"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41390-021-01715-z","article-title":"Platelets in pediatric and neonatal sepsis: novel mediators of the inflammatory cascade","volume":"91","author":"D O'Reilly","year":"2022","journal-title":"Pediatr Res"},{"issue":"01","key":"ref47","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/rth2.12465","article-title":"The role of platelets in sepsis","volume":"5","author":"O Shannon","year":"2020","journal-title":"Res Pract Thromb Haemost"},{"issue":"11","key":"ref48","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2362.1995.tb01694.x","article-title":"Platelet activation and interaction with leucocytes in patients with sepsis or multiple organ failure","volume":"25","author":"M Gawaz","year":"1995","journal-title":"Eur J Clin Invest"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fimmu.2015.00082","article-title":"Platelets and infections - complex interactions with bacteria","volume":"6","author":"H Hamzeh-Cognasse","year":"2015","journal-title":"Front Immunol"},{"issue":"04","key":"ref50","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s001340050344","article-title":"Platelet function in septic multiple organ dysfunction syndrome","volume":"23","author":"M Gawaz","year":"1997","journal-title":"Intensive Care Med"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1111\/j.1538-7836.2004.01009.x","article-title":"Platelet function in sepsis","volume":"2","author":"A Yaguchi","year":"2004","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref52","doi-asserted-by":"crossref","first-page":"R204","DOI":"10.1186\/cc11816","article-title":"Whole blood impedance aggregometry as a biomarker for the diagnosis and prognosis of severe sepsis","volume":"16","author":"M Adamzik","year":"2012","journal-title":"Crit Care"},{"issue":"06","key":"ref53","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/09537104.2016.1252837","article-title":"Higher platelet reactivity and platelet-monocyte complex formation in gram-positive sepsis compared to gram-negative sepsis","volume":"28","author":"R N Tunjungputri","year":"2017","journal-title":"Platelets"},{"issue":"04","key":"ref54","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/j.1538-7836.2011.04208.x","article-title":"The septic milieu triggers expression of spliced tissue factor mRNA in human platelets","volume":"9","author":"M T Rondina","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"12","key":"ref55","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1182\/blood.2019000067","article-title":"Sepsis alters the transcriptional and translational landscape of human and murine platelets","volume":"134","author":"E A Middleton","year":"2019","journal-title":"Blood"},{"issue":"02","key":"ref56","first-page":"350","article-title":"Sepsis-induced coagulopathy: an update on pathophysiology, biomarkers, and current guidelines","volume":"13","author":"A G Tsantes","year":"2023","journal-title":"Life (Basel)"},{"issue":"01","key":"ref57","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-2141.2009.07600.x","article-title":"Guidelines for the diagnosis and management of disseminated intravascular coagulation","volume":"145","author":"M Levi","year":"2009","journal-title":"Br J Haematol"},{"issue":"03","key":"ref58","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/joim.12331","article-title":"Endothelial barrier dysfunction in septic shock","volume":"277","author":"S M Opal","year":"2015","journal-title":"J Intern Med"},{"issue":"02","key":"ref59","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jth.13911","article-title":"Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis","volume":"16","author":"T Iba","year":"2018","journal-title":"J Thromb Haemost"},{"issue":"6667","key":"ref60","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/35393","article-title":"CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells","volume":"391","author":"V Henn","year":"1998","journal-title":"Nature"},{"issue":"01","key":"ref61","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jpeds.2007.06.036","article-title":"Developmental changes in soluble CD40 ligand","volume":"152","author":"J M Cholette","year":"2008","journal-title":"J Pediatr"},{"issue":"06","key":"ref62","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1160\/TH05-02-0127","article-title":"Chorioamnionitis is associated with increased CD40L expression on cord blood platelets","volume":"94","author":"A G Sitaru","year":"2005","journal-title":"Thromb Haemost"},{"issue":"10","key":"ref63","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1128\/IAI.67.10.5186-5191.1999","article-title":"Complement-dependent accumulation and degradation of platelets in the lung and liver induced by injection of lipopolysaccharides","volume":"67","author":"M Shibazaki","year":"1999","journal-title":"Infect Immun"},{"issue":"11","key":"ref64","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1007\/s00134-010-1969-3","article-title":"Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries","volume":"36","author":"D Secor","year":"2010","journal-title":"Intensive Care Med"},{"issue":"01","key":"ref65","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/cc3968","article-title":"Hepatic platelet and leukocyte adherence during endotoxemia","volume":"10","author":"R S Croner","year":"2006","journal-title":"Crit Care"},{"issue":"09","key":"ref66","doi-asserted-by":"crossref","first-page":"e0163531","DOI":"10.1371\/journal.pone.0163531","article-title":"The dynamics of platelet activation during the progression of streptococcal sepsis","volume":"11","author":"S M Hurley","year":"2016","journal-title":"PLoS One"},{"issue":"04","key":"ref67","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.4049\/jimmunol.117.4.1303","article-title":"Chemotactic and bactericidal capacities of human newborn monocytes","volume":"117","author":"R R Dretschmer","year":"1976","journal-title":"J Immunol"},{"issue":"02","key":"ref68","first-page":"189","article-title":"Mononuclear phagocytes in the newborn: their relation to the state of relative immunodeficiency","volume":"5","author":"E L Mills","year":"1983","journal-title":"Am J Pediatr Hematol Oncol"},{"issue":"05","key":"ref69","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/BF00439252","article-title":"Phagocytic activities in neonatal monocytes","volume":"145","author":"C P Speer","year":"1986","journal-title":"Eur J Pediatr"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-3782(01)00245-6","article-title":"Monocyte phagocytosis as a reliable parameter for predicting early-onset sepsis in very low birthweight infants","volume":"67","author":"U Hallwirth","year":"2002","journal-title":"Early Hum Dev"},{"issue":"02","key":"ref71","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1620\/tjem.240.167","article-title":"A term infant of neonatal toxic shock syndrome-like exanthematous disease complicated with hemophagocytic syndrome","volume":"240","author":"A Kaga","year":"2016","journal-title":"Tohoku J Exp Med"},{"issue":"02","key":"ref72","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5387\/fms.2022-03","article-title":"Peripheral platelet phagocytosis in an extremely low birth weight infant: a case report","volume":"68","author":"D Hatanaka","year":"2022","journal-title":"Fukushima J Med Sci"},{"issue":"03","key":"ref73","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3390\/jpm14030225","article-title":"The omics complexity in sepsis: the limits of the personalized medicine approach","volume":"14","author":"S Isac","year":"2024","journal-title":"J Pers Med"},{"issue":"06","key":"ref74","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.stemcr.2016.05.002","article-title":"Sepsis induces hematopoietic stem cell exhaustion and myelosuppression through distinct contributions of TRIF and MYD88","volume":"6","author":"H Zhang","year":"2016","journal-title":"Stem Cell Reports"},{"issue":"05","key":"ref75","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1182\/blood-2012-05-429589","article-title":"Steady-state neutrophil homeostasis is dependent on TLR4\/TRIF signaling","volume":"121","author":"S Bugl","year":"2013","journal-title":"Blood"},{"issue":"09","key":"ref76","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1093\/infdis\/jis505","article-title":"Differential roles of MyD88 and TRIF in hematopoietic and resident cells during murine gram-negative pneumonia","volume":"206","author":"M H van Lieshout","year":"2012","journal-title":"J Infect Dis"},{"issue":"19","key":"ref77","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1182\/blood-2009-04-214916","article-title":"Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis","volume":"114","author":"S Rodriguez","year":"2009","journal-title":"Blood"},{"issue":"02","key":"ref78","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0002-9343(97)00136-8","article-title":"Thrombocytopenia in the sepsis syndrome: role of hemophagocytosis and macrophage colony-stimulating factor","volume":"103","author":"B Fran\u00e7ois","year":"1997","journal-title":"Am J Med"},{"issue":"06","key":"ref79","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1097\/01.CCM.0000127779.24232.15","article-title":"Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients\u2013a postmortem clinicopathologic analysis","volume":"32","author":"R Strauss","year":"2004","journal-title":"Crit Care Med"},{"issue":"04","key":"ref80","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1177\/1753425914542445","article-title":"Delayed emergency myelopoiesis following polymicrobial sepsis in neonates","volume":"21","author":"A G Cuenca","year":"2015","journal-title":"Innate Immun"},{"issue":"03","key":"ref81","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4049\/jimmunol.1302676","article-title":"TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis","volume":"194","author":"A G Cuenca","year":"2015","journal-title":"J Immunol"},{"issue":"06","key":"ref82","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/tropej\/fmi031","article-title":"The effects of different infectious organisms on platelet counts and platelet indices in neonates with sepsis: is there an organism-specific response?","volume":"51","author":"S Akarsu","year":"2005","journal-title":"J Trop Pediatr"},{"issue":"01","key":"ref83","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s12887-020-02278-4","article-title":"Admission platelet count and indices as predictors of outcome in children with severe sepsis: a prospective hospital-based study","volume":"20","author":"S Z Sayed","year":"2020","journal-title":"BMC Pediatr"},{"issue":"24","key":"ref84","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1182\/blood-2015-11-680744","article-title":"Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients","volume":"127","author":"T A Claushuis","year":"2016","journal-title":"Blood"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1542\/peds.111.6.1411","article-title":"Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response?","volume":"111","author":"J D Guida","year":"2003","journal-title":"Pediatrics"},{"issue":"06","key":"ref86","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/adc.2006.111484","article-title":"Extreme thrombocytosis in admissions to paediatric intensive care: no requirement for treatment","volume":"92","author":"A Denton","year":"2007","journal-title":"Arch Dis Child"},{"issue":"01","key":"ref87","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ajcp\/99.1.69","article-title":"Mean platelet volume during coagulase-negative staphylococcal sepsis in neonates","volume":"99","author":"T A O'Connor","year":"1993","journal-title":"Am J Clin Pathol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1038\/srep08019","article-title":"Association of the immature platelet fraction with sepsis diagnosis and severity","volume":"5","author":"R M Enz Hubert","year":"2015","journal-title":"Sci Rep"},{"issue":"08","key":"ref89","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/jp.2013.21","article-title":"Low immature platelet fraction suggests decreased megakaryopoiesis in neonates with sepsis or necrotizing enterocolitis","volume":"33","author":"M Cremer","year":"2013","journal-title":"J Perinatol"},{"issue":"02","key":"ref90","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/09537104.2012.696748","article-title":"New insights into thrombopoiesis in neonatal sepsis","volume":"24","author":"D S Eissa","year":"2013","journal-title":"Platelets"},{"issue":"05","key":"ref91","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1055\/s-2001-16990","article-title":"Thrombopoietin levels of thrombocytopenic term and preterm newborns with infection","volume":"18","author":"N Oyg\u00fcr","year":"2001","journal-title":"Am J Perinatol"},{"issue":"04","key":"ref92","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1203\/PDR.0b013e318181ad49","article-title":"Effects of sepsis on neonatal thrombopoiesis","volume":"64","author":"R E Brown","year":"2008","journal-title":"Pediatr Res"},{"issue":"01","key":"ref93","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/j.semperi.2008.10.008","article-title":"New insights into the mechanisms of nonimmune 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Perinatol"},{"issue":"02","key":"ref97","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/00043426-198722000-00002","article-title":"Mean platelet volume and platelet distribution width in the neonate","volume":"9","author":"C H Patrick","year":"1987","journal-title":"Am J Pediatr Hematol Oncol"},{"issue":"01","key":"ref98","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1309\/AJCP4EMTJYA0VGYE","article-title":"Developmental differences in megakaryocyte size in infants and children","volume":"138","author":"D A Fuchs","year":"2012","journal-title":"Am J Clin Pathol"},{"issue":"02","key":"ref99","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1442-200X.2008.02689.x","article-title":"Is thrombocytopenia suggestive of organism-specific response in neonatal sepsis?","volume":"51","author":"P Manzoni","year":"2009","journal-title":"Pediatr Int"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"9605894","DOI":"10.1155\/2017\/9605894","article-title":"Toll-like receptor 4 signalling and its impact on platelet function, thrombosis, and haemostasis","volume":"2017","author":"T M Vallance","year":"2017","journal-title":"Mediators Inflamm"},{"issue":"07","key":"ref101","doi-asserted-by":"crossref","first-page":"e41549","DOI":"10.1371\/journal.pone.0041549","article-title":"Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb\/IIIa blockade","volume":"7","author":"M Sharron","year":"2012","journal-title":"PLoS One"},{"issue":"04","key":"ref102","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"S R Clark","year":"2007","journal-title":"Nat Med"},{"issue":"02","key":"ref103","doi-asserted-by":"crossref","first-page":"503","DOI":"10.4049\/jimmunol.1800897","article-title":"Complement activation occurs at the surface of platelets activated by streptococcal M1 protein and this results in phagocytosis of platelets","volume":"202","author":"F Palm","year":"2019","journal-title":"J Immunol"},{"issue":"12","key":"ref104","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1093\/infdis\/jit398","article-title":"Staphylococcus aureus lipoteichoic acid inhibits platelet activation and thrombus formation via the Paf receptor","volume":"208","author":"A K Waller","year":"2013","journal-title":"J Infect Dis"},{"issue":"06","key":"ref105","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.chom.2015.05.011","article-title":"Synergistic action of Staphylococcus aureus \u03b1-toxin on platelets and myeloid lineage cells contributes to lethal sepsis","volume":"17","author":"M E Powers","year":"2015","journal-title":"Cell Host Microbe"},{"issue":"04","key":"ref106","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1046\/j.1365-2958.2002.02935.x","article-title":"Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A","volume":"44","author":"L O'Brien","year":"2002","journal-title":"Mol Microbiol"},{"issue":"01","key":"ref107","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/antibiotics14010101","article-title":"Thromboelastometry-based profiling of haemostatic alterations in neonatal sepsis by causative pathogens","volume":"14","author":"R Sokou","year":"2025","journal-title":"Antibiotics (Basel)"},{"issue":"02","key":"ref108","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1542\/peds.2005-0333","article-title":"Persistent bacteremia and severe thrombocytopenia caused by coagulase-negative Staphylococcus in a neonatal intensive care unit","volume":"117","author":"M Khashu","year":"2006","journal-title":"Pediatrics"},{"issue":"04","key":"ref109","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ajic.2003.07.004","article-title":"Enteric gram-negative bacilli bloodstream infections: 17 years' experience in a neonatal intensive care unit","volume":"32","author":"L Cordero","year":"2004","journal-title":"Am J Infect Control"},{"issue":"02","key":"ref110","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/ajcp\/83.2.227","article-title":"Endotoxinemia and thrombocytopenia during neonatal necrotizing enterocolitis","volume":"83","author":"D W Scheifele","year":"1985","journal-title":"Am J Clin Pathol"},{"issue":"03","key":"ref111","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00000658-197509000-00010","article-title":"The early diagnosis of gram negative septicemia in the pediatric surgical patient","volume":"182","author":"M I Rowe","year":"1975","journal-title":"Ann Surg"},{"issue":"23","key":"ref112","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1161\/01.CIR.99.23.3056","article-title":"Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia","volume":"99","author":"J-R Sheu","year":"1999","journal-title":"Circulation"},{"issue":"01","key":"ref113","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1084\/jem.147.1.207","article-title":"Enhancement of platelet response to immune complexes and IgG aggregates by lipid A-rich bacterial lipopolysaccharides","volume":"147","author":"M H Ginsberg","year":"1978","journal-title":"J Exp Med"},{"issue":"01","key":"ref114","doi-asserted-by":"crossref","first-page":"317","DOI":"10.4049\/jimmunol.120.1.317","article-title":"The selective binding of aggregated IgG to lipid A-rich bacterial lipopolysaccharides","volume":"120","author":"M H Ginsberg","year":"1978","journal-title":"J Immunol"},{"issue":"04","key":"ref115","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1128\/iai.65.4.1321-1326.1997","article-title":"A protective role of platelet-activating factor in murine candidiasis","volume":"65","author":"S Y Im","year":"1997","journal-title":"Infect Immun"},{"issue":"01","key":"ref116","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/jof11010017","article-title":"The role of rotational thromboelastometry in early detection of the hemostatic derangements in neonates with systemic candida infection","volume":"11","author":"R Sokou","year":"2024","journal-title":"J Fungi (Basel)"},{"issue":"05","key":"ref117","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1055\/a-2564-7613","article-title":"Hemostatic manifestations of invasive fungal infections: a comprehensive review of pathophysiological mechanisms in sepsis-induced hemostatic disturbances, with a focus on the neonatal population","volume":"51","author":"A Lianou","year":"2025","journal-title":"Semin Thromb Hemost"},{"issue":"01","key":"ref118","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/09537104.2017.1293810","article-title":"Value of platelet count in the early diagnosis of nosocomial invasive fungal infections in premature infants","volume":"29","author":"Y C Yang","year":"2018","journal-title":"Platelets"},{"issue":"03","key":"ref119","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1128\/IAI.01091-09","article-title":"Activation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of Aspergillosis","volume":"78","author":"E K R\u00f8dland","year":"2010","journal-title":"Infect Immun"},{"issue":"04","key":"ref120","doi-asserted-by":"crossref","first-page":"e00784-19","DOI":"10.1128\/IAI.00784-19","article-title":"Stepping up to the plate(let) against Candida albicans","volume":"88","author":"C M Schultz","year":"2020","journal-title":"Infect Immun"},{"issue":"02","key":"ref121","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1182\/blood-2005-06-2202","article-title":"Platelet toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-\u03b1 production in vivo","volume":"107","author":"R Aslam","year":"2006","journal-title":"Blood"},{"key":"ref122","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fmed.2018.00017","article-title":"Toward the relevance of platelet subpopulations for transfusion medicine","volume":"5","author":"S Handtke","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"ref123","first-page":"blood.2025028955","article-title":"Platelet heterogeneity: variety makes immune and vascular function better","author":"M Malloy","year":"2025","journal-title":"Blood"},{"key":"ref124","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev-immunol-042718-041607","article-title":"The platelet Napoleon complex-small cells, but big immune regulatory functions","volume":"37","author":"C N Morrell","year":"2019","journal-title":"Annu Rev Immunol"},{"issue":"02","key":"ref125","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1172\/JCI71858","article-title":"Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection","volume":"124","author":"G Shi","year":"2014","journal-title":"J Clin Invest"},{"issue":"24","key":"ref126","doi-asserted-by":"crossref","first-page":"11955","DOI":"10.18632\/aging.102520","article-title":"Platelet-derived \u03b22m regulates age related monocyte\/macrophage functions","volume":"11","author":"Z T Hilt","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"06","key":"ref127","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1182\/blood-2012-02-413047","article-title":"Platelets can enhance vascular permeability","volume":"120","author":"N Cloutier","year":"2012","journal-title":"Blood"},{"issue":"22","key":"ref128","doi-asserted-by":"crossref","first-page":"e181111","DOI":"10.1172\/JCI181111","article-title":"Long-lived lung megakaryocytes contribute to platelet recovery in thrombocytopenia models","volume":"134","author":"A C Livada","year":"2024","journal-title":"J Clin Invest"},{"issue":"01","key":"ref129","doi-asserted-by":"crossref","first-page":"e137377","DOI":"10.1172\/JCI137377","article-title":"Lung megakaryocytes are immune modulatory cells","volume":"131","author":"D N Pariser","year":"2021","journal-title":"J Clin Invest"},{"issue":"7648","key":"ref130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature21706","article-title":"The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors","volume":"544","author":"E Lefran\u00e7ais","year":"2017","journal-title":"Nature"},{"issue":"18","key":"ref131","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1182\/blood.2024027884","article-title":"Decoding functional hematopoietic progenitor cells in the adult human lung","volume":"145","author":"C Conrad","year":"2025","journal-title":"Blood"},{"issue":"04","key":"ref132","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1161\/ATVBAHA.114.304954","article-title":"Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors","volume":"35","author":"M Koupenova","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"ref133","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1074\/mcp.M114.038513","article-title":"Copy number analysis of the murine platelet proteome spanning the complete abundance range","volume":"13","author":"M Zeiler","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"15","key":"ref134","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1182\/blood-2012-04-416594","article-title":"The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways","volume":"120","author":"J M Burkhart","year":"2012","journal-title":"Blood"},{"issue":"12","key":"ref135","doi-asserted-by":"crossref","first-page":"6524","DOI":"10.1128\/IAI.70.12.6524-6533.2002","article-title":"Antimicrobial peptides from human platelets","volume":"70","author":"Y Q Tang","year":"2002","journal-title":"Infect Immun"},{"issue":"04","key":"ref136","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.blre.2009.04.001","article-title":"Platelet alpha-granules: basic biology and clinical correlates","volume":"23","author":"P Blair","year":"2009","journal-title":"Blood Rev"},{"key":"ref137","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.3389\/fimmu.2018.02712","article-title":"Role of platelets in leukocyte recruitment and resolution of inflammation","volume":"9","author":"J Rossaint","year":"2018","journal-title":"Front Immunol"},{"issue":"08","key":"ref138","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll-like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"S Akira","year":"2001","journal-title":"Nat Immunol"},{"issue":"01","key":"ref139","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-065X.2008.00701.x","article-title":"The interleukin-1 receptor\/toll-like receptor superfamily: 10 years of progress","volume":"226","author":"L A O'Neill","year":"2008","journal-title":"Immunol Rev"},{"issue":"03","key":"ref140","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2005.06.015","article-title":"Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets","volume":"122","author":"M M Denis","year":"2005","journal-title":"Cell"},{"issue":"22","key":"ref141","doi-asserted-by":"crossref","first-page":"5963","DOI":"10.1182\/blood-2010-09-304949","article-title":"Regulatory effects of TLR2 on megakaryocytic cell function","volume":"117","author":"L M Beaulieu","year":"2011","journal-title":"Blood"},{"issue":"03","key":"ref142","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/CIRCRESAHA.108.185785","article-title":"Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase","volume":"104","author":"P Blair","year":"2009","journal-title":"Circ Res"},{"issue":"01","key":"ref143","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1016\/j.thromres.2010.10.023","article-title":"Periodontopathogens induce soluble P-selectin release by endothelial cells and platelets","volume":"127","author":"A Assinger","year":"2011","journal-title":"Thromb Res"},{"issue":"05","key":"ref144","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1182\/blood-2013-11-536003","article-title":"Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis","volume":"124","author":"M Koupenova","year":"2014","journal-title":"Blood"},{"issue":"04","key":"ref145","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1083\/jcb.201111136","article-title":"T granules in human platelets function in TLR9 organization and signaling","volume":"198","author":"J N Thon","year":"2012","journal-title":"J Cell Biol"},{"issue":"11","key":"ref146","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1182\/blood-2006-12-062695","article-title":"Platelet-bound lipopolysaccharide enhances Fc receptor-mediated phagocytosis of IgG-opsonized platelets","volume":"109","author":"J W Semple","year":"2007","journal-title":"Blood"},{"issue":"01","key":"ref147","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12865-015-0067-2","article-title":"LPS stimulation of purified human platelets is partly dependent on plasma soluble CD14 to secrete their main secreted product, soluble-CD40-Ligand","volume":"16","author":"P Damien","year":"2015","journal-title":"BMC Immunol"},{"issue":"03","key":"ref148","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1080\/09537104.2018.1445841","article-title":"Platelet toll-like receptor expression and activation induced by lipopolysaccharide and sepsis","volume":"30","author":"T AM Claushuis","year":"2019","journal-title":"Platelets"},{"issue":"02","key":"ref149","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1086\/509892","article-title":"Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling","volume":"195","author":"K Sadeghi","year":"2007","journal-title":"J Infect Dis"},{"issue":"04","key":"ref150","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.chom.2018.09.011","article-title":"Accelerated aging and clearance of host anti-inflammatory enzymes by discrete pathogens fuels sepsis","volume":"24","author":"W H Yang","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"10","key":"ref151","doi-asserted-by":"crossref","first-page":"5464","DOI":"10.4049\/jimmunol.161.10.5464","article-title":"The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity","volume":"161","author":"A B Schromm","year":"1998","journal-title":"J Immunol"},{"issue":"06","key":"ref152","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/00024382-200212000-00013","article-title":"Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide","volume":"18","author":"H Bentala","year":"2002","journal-title":"Shock"},{"issue":"50","key":"ref153","doi-asserted-by":"crossref","first-page":"20218","DOI":"10.1073\/pnas.1313905110","article-title":"Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor","volume":"110","author":"P K Grewal","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref154","doi-asserted-by":"crossref","first-page":"e15044","DOI":"10.1371\/journal.pone.0015044","article-title":"Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis","volume":"5","author":"A Soliman","year":"2010","journal-title":"PLoS One"},{"issue":"05","key":"ref155","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.4049\/jimmunol.180.5.3478","article-title":"Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor","volume":"180","author":"S Knapp","year":"2008","journal-title":"J Immunol"},{"issue":"01","key":"ref156","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3565","article-title":"NOD proteins: regulators of inflammation in health and disease","volume":"14","author":"D J Philpott","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"13","key":"ref157","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCULATIONAHA.114.013743","article-title":"Nucleotide-binding oligomerization domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis","volume":"131","author":"S Zhang","year":"2015","journal-title":"Circulation"},{"issue":"04","key":"ref158","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jhep.2010.04.026","article-title":"Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production","volume":"53","author":"M J Scott","year":"2010","journal-title":"J Hepatol"},{"key":"ref159","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.ijbiomac.2018.10.052","article-title":"Nucleotide-binding oligomerization domain (NOD) plays an important role in neonatal infection","volume":"121","author":"Y Chen","year":"2019","journal-title":"Int J Biol Macromol"},{"issue":"03","key":"ref160","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000321109","article-title":"Enhancement of mast cell IL-6 production by combined toll-like and nucleotide-binding oligomerization domain-like receptor activation","volume":"154","author":"I D Haidl","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"issue":"05","key":"ref161","doi-asserted-by":"crossref","first-page":"e212","DOI":"10.1111\/apa.12559","article-title":"NOD1 and NOD2 expression and function in very preterm infant mononuclear cells","volume":"103","author":"C Granland","year":"2014","journal-title":"Acta Paediatr"},{"issue":"08","key":"ref162","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"K V Swanson","year":"2019","journal-title":"Nat Rev Immunol"},{"issue":"09","key":"ref163","doi-asserted-by":"crossref","first-page":"e14073","DOI":"10.14814\/phy2.14073","article-title":"NLRP3 inflammasome activation in platelets in response to sepsis","volume":"7","author":"D C Cornelius","year":"2019","journal-title":"Physiol Rep"},{"issue":"02","key":"ref164","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Y Yang","year":"2019","journal-title":"Cell Death Dis"},{"issue":"09","key":"ref165","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.3324\/haematol.2018.191700","article-title":"NLRP3 regulates platelet integrin \u03b1IIb\u03b23 outside-in signaling, hemostasis and arterial thrombosis","volume":"103","author":"J Qiao","year":"2018","journal-title":"Haematologica"},{"issue":"06","key":"ref166","doi-asserted-by":"crossref","first-page":"107615","DOI":"10.1016\/j.celrep.2020.107615","article-title":"Platelets fuel the inflammasome activation of innate immune cells","volume":"31","author":"V Rolfes","year":"2020","journal-title":"Cell Rep"},{"key":"ref167","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cyto.2018.08.008","article-title":"In situ inflammasome activation results in severe damage to the central nervous system in fatal Zika virus microcephaly cases","volume":"111","author":"J R de Sousa","year":"2018","journal-title":"Cytokine"},{"issue":"05","key":"ref168","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1159\/000507584","article-title":"Emerging role of the NLRP3 inflammasome and interleukin-1\u03b2 in neonates","volume":"117","author":"M Omer","year":"2020","journal-title":"Neonatology"},{"issue":"04","key":"ref169","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.3390\/ijms16048635","article-title":"Interleukin-1 receptor antagonist reduces neonatal lipopolysaccharide-induced long-lasting neurobehavioral deficits and dopaminergic neuronal injury in adult rats","volume":"16","author":"Y Pang","year":"2015","journal-title":"Int J Mol Sci"},{"issue":"08","key":"ref170","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.bbi.2012.09.001","article-title":"Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and\/or hypoxic-ischemic injuries","volume":"26","author":"S Girard","year":"2012","journal-title":"Brain Behav Immun"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12974-015-0330-8","article-title":"Neuronal self-injury mediated by IL-1\u03b2 and MMP-9 in a cerebral palsy model of severe neonatal encephalopathy induced by immune activation plus hypoxia-ischemia","volume":"12","author":"A Savard","year":"2015","journal-title":"J Neuroinflammation"},{"key":"ref172","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ijdevneu.2018.07.004","article-title":"Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury in the neonatal male rat","volume":"69","author":"A Chen","year":"2018","journal-title":"Int J Dev Neurosci"},{"issue":"05","key":"ref173","doi-asserted-by":"crossref","first-page":"e0196352","DOI":"10.1371\/journal.pone.0196352","article-title":"Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro","volume":"13","author":"E M Speer","year":"2018","journal-title":"PLoS One"},{"key":"ref174","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.3389\/fimmu.2019.01480","article-title":"Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension","volume":"10","author":"C B Bui","year":"2019","journal-title":"Front Immunol"},{"issue":"01","key":"ref175","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/art.25057","article-title":"Long-term efficacy of the interleukin-1 receptor antagonist anakinra in ten patients with neonatal-onset multisystem inflammatory disease\/chronic infantile neurologic, cutaneous, articular syndrome","volume":"62","author":"B Neven","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"18","key":"ref176","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1128\/JVI.00136-06","article-title":"DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets","volume":"80","author":"C Chaipan","year":"2006","journal-title":"J Virol"},{"issue":"16","key":"ref177","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1182\/blood-2009-05-222273","article-title":"CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis","volume":"114","author":"F May","year":"2009","journal-title":"Blood"},{"issue":"09","key":"ref178","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nri1182","article-title":"DC-SIGN: escape mechanism for pathogens","volume":"3","author":"Y van Kooyk","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"02","key":"ref179","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1538-7836.2006.01749.x","article-title":"Lentivirus degradation and DC-SIGN expression by human platelets and megakaryocytes","volume":"4","author":"S Boukour","year":"2006","journal-title":"J Thromb Haemost"},{"issue":"03","key":"ref180","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1182\/blood-2014-09-598029","article-title":"Dengue virus binding and replication by platelets","volume":"126","author":"A Y Simon","year":"2015","journal-title":"Blood"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"36222","DOI":"10.1038\/srep36222","article-title":"Metformin uniquely prevents thrombosis by inhibiting platelet activation and mtDNA release","volume":"6","author":"G Xin","year":"2016","journal-title":"Sci Rep"},{"issue":"04","key":"ref182","doi-asserted-by":"crossref","first-page":"e1008483","DOI":"10.1371\/journal.ppat.1008483","article-title":"RIG-I-like receptor activation drives type I IFN and antiviral signaling to limit Hantaan orthohantavirus replication","volume":"16","author":"A M Kell","year":"2020","journal-title":"PLoS Pathog"},{"issue":"01","key":"ref183","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1038\/s41467-019-10360-4","article-title":"Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A\/TLR2","volume":"10","author":"P S Sung","year":"2019","journal-title":"Nat Commun"},{"issue":"01","key":"ref184","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/ATVBAHA.120.314645","article-title":"Role of platelets in detection and regulation of infection","volume":"41","author":"I Portier","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"ref185","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1172\/JCI79070","article-title":"Inflammation drives thrombosis after Salmonella infection via CLEC-2 on platelets","volume":"125","author":"J R Hitchcock","year":"2015","journal-title":"J Clin Invest"},{"issue":"01","key":"ref186","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1038\/s41467-017-02402-6","article-title":"The podoplanin-CLEC-2 axis inhibits inflammation in sepsis","volume":"8","author":"J Rayes","year":"2017","journal-title":"Nat Commun"},{"issue":"7469","key":"ref187","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature12501","article-title":"Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2","volume":"502","author":"B H Herzog","year":"2013","journal-title":"Nature"},{"issue":"20","key":"ref188","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1182\/blood-2013-03-489286","article-title":"CLEC-2 is required for development and maintenance of lymph nodes","volume":"123","author":"C B\u00e9n\u00e9zech","year":"2014","journal-title":"Blood"},{"issue":"04","key":"ref189","doi-asserted-by":"crossref","first-page":"e19190","DOI":"10.1371\/journal.pone.0019190","article-title":"GPVI and GPIb\u03b1 mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors","volume":"6","author":"H Hu","year":"2011","journal-title":"PLoS One"},{"issue":"03","key":"ref190","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1182\/bloodadvances.2017011171","article-title":"Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI","volume":"2","author":"S J Montague","year":"2018","journal-title":"Blood Adv"},{"issue":"08","key":"ref191","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1182\/blood-2017-06-788067","article-title":"Platelet glycoprotein VI aids in local immunity during pneumonia-derived sepsis caused by gram-negative bacteria","volume":"131","author":"T AM Claushuis","year":"2018","journal-title":"Blood"},{"key":"ref192","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1099\/vir.0.81826-0","article-title":"Hepatitis C virus interacts with human platelet glycoprotein VI","volume":"87","author":"A Zahn","year":"2006","journal-title":"J Gen Virol"},{"issue":"08","key":"ref193","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1538-7836.2009.03495.x","article-title":"Elucidating the role of Staphylococcus epidermidis serine-aspartate repeat protein G in platelet activation","volume":"7","author":"M P Brennan","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref194","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1128\/IAI.00664-09","article-title":"Human platelets recognize a novel surface protein, PadA, on Streptococcus gordonii through a unique interaction involving fibrinogen receptor GPIIbIIIa","volume":"78","author":"H J Petersen","year":"2010","journal-title":"Infect Immun"},{"issue":"03","key":"ref195","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1365-2958.2005.04731.x","article-title":"Roles for fibrinogen, immunoglobulin and complement in platelet activation promoted by Staphylococcus aureus clumping factor A","volume":"57","author":"A Loughman","year":"2005","journal-title":"Mol Microbiol"},{"issue":"05","key":"ref196","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1365-2958.2007.05841.x","article-title":"Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation","volume":"65","author":"O Shannon","year":"2007","journal-title":"Mol Microbiol"},{"issue":"01","key":"ref197","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1182\/blood-2024-200231","article-title":"High dimensional immunophenotyping of neonatal and adult platelets: differential reactivity to agonists, maximal marker expression, and abundance of defined platelet subsets","volume":"144","author":"A L Frelinger III","year":"2024","journal-title":"Blood"},{"issue":"06","key":"ref198","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/jth.12905","article-title":"Human platelet IgG Fc receptor Fc\u03b3RIIA in immunity and thrombosis","volume":"13","author":"M Arman","year":"2015","journal-title":"J Thromb Haemost"},{"issue":"09","key":"ref199","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrmicro3521","article-title":"Staphylococcal manipulation of host immune responses","volume":"13","author":"V Thammavongsa","year":"2015","journal-title":"Nat Rev Microbiol"},{"issue":"06","key":"ref200","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.cell.2017.11.001","article-title":"Migrating platelets are mechano-scavengers that collect and bundle bacteria","volume":"171","author":"F Gaertner","year":"2017","journal-title":"Cell"},{"issue":"11","key":"ref201","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1128\/IAI.72.11.6528-6537.2004","article-title":"The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibalpha","volume":"72","author":"B A Bensing","year":"2004","journal-title":"Infect Immun"},{"issue":"01","key":"ref202","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1365-2141.2005.05421.x","article-title":"A serine-rich glycoprotein of Streptococcus sanguis mediates adhesion to platelets via GPIb","volume":"129","author":"C Plummer","year":"2005","journal-title":"Br J Haematol"},{"issue":"07","key":"ref203","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/S0016-5085(03)00397-4","article-title":"Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation","volume":"124","author":"M F Byrne","year":"2003","journal-title":"Gastroenterology"},{"issue":"08","key":"ref204","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.2631","article-title":"Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance","volume":"14","author":"C H Wong","year":"2013","journal-title":"Nat Immunol"},{"issue":"01","key":"ref205","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1038\/s41598-018-20914-z","article-title":"Selective tropism of dengue virus for human glycoprotein Ib","volume":"8","author":"N Attatippaholkun","year":"2018","journal-title":"Sci Rep"},{"issue":"03","key":"ref206","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/09537100701882046","article-title":"The effect of gestational age on platelet surface expression of CD62P in preterm newborns","volume":"19","author":"A Wasiluk","year":"2008","journal-title":"Platelets"},{"issue":"11","key":"ref207","first-page":"CR545","article-title":"The expression of vWF receptor on newborn platelets","volume":"11","author":"A Wasiluk","year":"2005","journal-title":"Med Sci Monit"},{"issue":"09","key":"ref208","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.3390\/ijms22094883","article-title":"Age-dependent control of collagen-dependent platelet responses by thrombospondin-1-comparative analysis of platelets from neonates, children, adolescents, and adults","volume":"22","author":"K Herken","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref209","first-page":"431","volume-title":"CHAPTER 22 - Platelet Function in the Newborn","author":"S J Israels","year":"2007"},{"issue":"16","key":"ref210","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.3390\/cells11162563","article-title":"Neonatal platelets: lower G12\/13 expression contributes to reduced secretion of dense granules","volume":"11","author":"A Schlagenhauf","year":"2022","journal-title":"Cells"},{"issue":"05","key":"ref211","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.bcp.2008.11.017","article-title":"RhoA downstream of G(q) and G(12\/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets","volume":"77","author":"J Jin","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"22","key":"ref212","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1182\/blood.2020009774","article-title":"Acquired platelet GPVI receptor dysfunction in critically ill patients with sepsis","volume":"137","author":"L J Weiss","year":"2021","journal-title":"Blood"},{"issue":"05","key":"ref213","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1476-5381.2012.02097.x","article-title":"The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL","volume":"167","author":"Y I Miller","year":"2012","journal-title":"Br J Pharmacol"},{"issue":"04","key":"ref214","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.4049\/jimmunol.172.4.2011","article-title":"Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification","volume":"172","author":"S Danese","year":"2004","journal-title":"J Immunol"},{"issue":"07","key":"ref215","doi-asserted-by":"crossref","first-page":"E1550","DOI":"10.1073\/pnas.1720553115","article-title":"Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration","volume":"115","author":"N Cloutier","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"01","key":"ref216","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1160\/TH08-08-0513","article-title":"Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release","volume":"102","author":"S Rex","year":"2009","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref217","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41569-019-0326-7","article-title":"Neutrophils as regulators of cardiovascular inflammation","volume":"17","author":"C Silvestre-Roig","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"20","key":"ref218","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1161\/01.CIR.103.20.2501","article-title":"Beta(3)-integrin-deficient mice but not P-selectin-deficient mice develop intimal hyperplasia after vascular injury: correlation with leukocyte recruitment to adherent platelets 1\u2009hour after injury","volume":"103","author":"S S Smyth","year":"2001","journal-title":"Circulation"},{"issue":"23","key":"ref219","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.3390\/cells11233944","article-title":"Role of S100A8\/A9 in platelet-neutrophil complex formation during acute inflammation","volume":"11","author":"J Revenstorff","year":"2022","journal-title":"Cells"},{"issue":"06","key":"ref220","doi-asserted-by":"crossref","first-page":"111614","DOI":"10.1016\/j.celrep.2022.111614","article-title":"Platelet p110\u03b2 mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia","volume":"41","author":"W C Schrottmaier","year":"2022","journal-title":"Cell Rep"},{"issue":"06","key":"ref221","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.cell.2022.03.003","article-title":"GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA","volume":"185","author":"M De Giovanni","year":"2022","journal-title":"Cell"},{"issue":"01","key":"ref222","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1038\/s41467-020-15584-3","article-title":"The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure","volume":"11","author":"A Chauhan","year":"2020","journal-title":"Nat Commun"},{"issue":"02","key":"ref223","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"V Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"01","key":"ref224","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s13054-020-03082-3","article-title":"Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock","volume":"24","author":"Y Jiao","year":"2020","journal-title":"Crit Care"},{"issue":"01","key":"ref225","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/s41467-019-09607-x","article-title":"The role of platelets in mediating a response to human influenza infection","volume":"10","author":"M Koupenova","year":"2019","journal-title":"Nat Commun"},{"issue":"10","key":"ref226","doi-asserted-by":"crossref","first-page":"e154225","DOI":"10.1172\/JCI154225","article-title":"Neutrophil extracellular traps regulate ischemic stroke brain injury","volume":"132","author":"F Denorme","year":"2022","journal-title":"J Clin Invest"},{"issue":"12","key":"ref227","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1172\/JCI81660","article-title":"Platelet-derived HMGB1 is a critical mediator of thrombosis","volume":"125","author":"S Vogel","year":"2015","journal-title":"J Clin Invest"},{"issue":"11","key":"ref228","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1172\/JCI141374","article-title":"Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis","volume":"130","author":"P Skendros","year":"2020","journal-title":"J Clin Invest"},{"key":"ref229","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3389\/fimmu.2016.00271","article-title":"Platelets: new bricks in the building of neutrophil extracellular traps","volume":"7","author":"A Carestia","year":"2016","journal-title":"Front Immunol"},{"issue":"02","key":"ref230","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/art.41926","article-title":"Platelet phagocytosis via P-selectin glycoprotein ligand 1 and accumulation of microparticles in systemic sclerosis","volume":"74","author":"A A Manfredi","year":"2022","journal-title":"Arthritis Rheumatol"},{"issue":"01","key":"ref231","doi-asserted-by":"crossref","first-page":"e23559","DOI":"10.1016\/j.heliyon.2023.e23559","article-title":"Neutrophil extracellular traps in adult diseases and neonatal bacterial infectious diseases: a review","volume":"10","author":"Z Li","year":"2023","journal-title":"Heliyon"},{"issue":"12","key":"ref232","doi-asserted-by":"crossref","first-page":"7413","DOI":"10.4049\/jimmunol.1000675","article-title":"A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus","volume":"185","author":"F H Pilsczek","year":"2010","journal-title":"J Immunol"},{"issue":"09","key":"ref233","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nm.2847","article-title":"Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo","volume":"18","author":"B G Yipp","year":"2012","journal-title":"Nat Med"},{"issue":"06","key":"ref234","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2018.12.006","article-title":"Neutrophils stepping through (to the other side)","volume":"49","author":"V Papayannopoulos","year":"2018","journal-title":"Immunity"},{"issue":"10","key":"ref235","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1182\/blood-2016-09-741298","article-title":"Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice","volume":"129","author":"B McDonald","year":"2017","journal-title":"Blood"},{"issue":"06","key":"ref236","doi-asserted-by":"crossref","first-page":"e286","DOI":"10.1097\/PCC.0000000000001496","article-title":"Neutrophil extracellular traps in children with meningococcal sepsis","volume":"19","author":"T Hoppenbrouwers","year":"2018","journal-title":"Pediatr Crit Care Med"},{"issue":"12","key":"ref237","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1111\/jth.12710","article-title":"Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps","volume":"12","author":"N Maugeri","year":"2014","journal-title":"J Thromb Haemost"},{"issue":"07","key":"ref238","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1172\/JCI61303","article-title":"Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury","volume":"122","author":"A Caudrillier","year":"2012","journal-title":"J Clin Invest"},{"issue":"01","key":"ref239","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1038\/s41467-018-04947-6","article-title":"Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity","volume":"9","author":"H He","year":"2018","journal-title":"Nat Commun"},{"issue":"08","key":"ref240","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nm.2184","article-title":"Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases","volume":"16","author":"S Massberg","year":"2010","journal-title":"Nat Med"},{"issue":"04","key":"ref241","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.20112322","article-title":"Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo","volume":"209","author":"M L von Br\u00fchl","year":"2012","journal-title":"J Exp Med"},{"issue":"25","key":"ref242","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1182\/blood-2008-07-171629","article-title":"Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates","volume":"113","author":"C C Yost","year":"2009","journal-title":"Blood"},{"issue":"01","key":"ref243","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41390-019-0389-5","article-title":"Pediatric immunothrombosis-Understudied\u2026 but what potential!","volume":"86","author":"C C Yost","year":"2019","journal-title":"Pediatr Res"},{"issue":"02","key":"ref244","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000452615","article-title":"Less neutrophil extracellular trap formation in term newborns than in adults","volume":"111","author":"P Lipp","year":"2017","journal-title":"Neonatology"},{"issue":"01","key":"ref245","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13054-019-2407-8","article-title":"Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis","volume":"23","author":"D F Col\u00f3n","year":"2019","journal-title":"Crit Care"},{"issue":"10","key":"ref246","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1172\/JCI83873","article-title":"Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation","volume":"126","author":"C C Yost","year":"2016","journal-title":"J Clin Invest"},{"key":"ref247","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fimmu.2018.00337","article-title":"Development and application of high-content biological screening for modulators of NET production","volume":"9","author":"I J Chicca","year":"2018","journal-title":"Front Immunol"},{"issue":"05","key":"ref248","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.chom.2010.10.005","article-title":"Statins enhance formation of phagocyte extracellular traps","volume":"8","author":"O A Chow","year":"2010","journal-title":"Cell Host Microbe"},{"issue":"02","key":"ref249","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1164\/rccm.201501-0161OC","article-title":"Inhibition of neutrophil extracellular trap formation after stem cell transplant by prostaglandin E2","volume":"193","author":"R Domingo-Gonzalez","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"05","key":"ref250","doi-asserted-by":"crossref","first-page":"e64443","DOI":"10.1371\/journal.pone.0064443","article-title":"Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury","volume":"8","author":"C C Garcia","year":"2013","journal-title":"PLoS One"},{"issue":"16","key":"ref251","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1182\/blood-2013-07-516484","article-title":"Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation","volume":"123","author":"J Rossaint","year":"2014","journal-title":"Blood"},{"issue":"6214","key":"ref252","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1126\/science.1256478","article-title":"Neutrophils scan for activated platelets to initiate inflammation","volume":"346","author":"V Sreeramkumar","year":"2014","journal-title":"Science"},{"issue":"04","key":"ref253","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.intimp.2013.06.004","article-title":"Neutrophil and platelet complexes and their relevance to neutrophil recruitment and activation","volume":"17","author":"C Page","year":"2013","journal-title":"Int Immunopharmacol"},{"issue":"01","key":"ref254","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MOH.0000000000000297","article-title":"Platelets in neutrophil recruitment to sites of inflammation","volume":"24","author":"S Pitchford","year":"2017","journal-title":"Curr Opin Hematol"},{"issue":"05","key":"ref255","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1084\/jem.20020267","article-title":"The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1","volume":"196","author":"S Santoso","year":"2002","journal-title":"J Exp Med"},{"issue":"03","key":"ref256","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1055\/s-0037-1615227","article-title":"Platelet associated fibrinogen and ICAM-2 induce firm adhesion of neutrophils under flow conditions","volume":"80","author":"P H Kuijper","year":"1998","journal-title":"Thromb Haemost"},{"issue":"10","key":"ref257","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1161\/CIRCULATIONAHA.118.036323","article-title":"Platelet protein disulfide isomerase promotes glycoprotein Ib\u03b1-mediated platelet-neutrophil interactions under thromboinflammatory conditions","volume":"139","author":"J Li","year":"2019","journal-title":"Circulation"},{"key":"ref258","doi-asserted-by":"crossref","first-page":"e53353","DOI":"10.7554\/eLife.53353","article-title":"Activated \u03b1IIb\u03b23 on platelets mediates flow-dependent NETosis via SLC44A2","volume":"9","author":"A Constantinescu-Bercu","year":"2020","journal-title":"eLife"},{"issue":"07","key":"ref259","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1182\/blood-2005-04-1530","article-title":"Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin","volume":"106","author":"V S Dole","year":"2005","journal-title":"Blood"},{"issue":"03","key":"ref260","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1182\/blood.V70.3.740.740","article-title":"Abnormal stimulated adherence of neonatal granulocytes: impaired induction of surface Mac-1 by chemotactic factors or secretagogues","volume":"70","author":"D C Anderson","year":"1987","journal-title":"Blood"},{"issue":"04","key":"ref261","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1182\/blood.V83.4.1086.1086","article-title":"Deficient total cell content of CR3 (CD11b) in neonatal neutrophils","volume":"83","author":"N Abughali","year":"1994","journal-title":"Blood"},{"issue":"12","key":"ref262","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1182\/blood.V76.12.2613.2613","article-title":"Impaired transendothelial migration by neonatal neutrophils: abnormalities of Mac-1 (CD11b\/CD18)-dependent adherence reactions","volume":"76","author":"D C Anderson","year":"1990","journal-title":"Blood"},{"issue":"03","key":"ref263","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s12975-021-00938-w","article-title":"Platelet activation and chemokine release are related to local neutrophil-dominant inflammation during hyperacute human stroke","volume":"13","author":"A M Kollikowski","year":"2022","journal-title":"Transl Stroke Res"},{"issue":"01","key":"ref264","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41598-020-80685-4","article-title":"Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis","volume":"11","author":"K Matsumoto","year":"2021","journal-title":"Sci Rep"},{"issue":"02","key":"ref265","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1165\/rcmb.2015-0245OC","article-title":"Platelet-specific chemokines contribute to the pathogenesis of acute lung injury","volume":"56","author":"K Bdeir","year":"2017","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"24","key":"ref266","doi-asserted-by":"crossref","first-page":"13576","DOI":"10.3390\/ijms222413576","article-title":"CXCR4 and CXCR7 inhibition ameliorates the formation of platelet-neutrophil complexes and neutrophil extracellular traps through Adora2b signaling","volume":"22","author":"K C Ngamsri","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref267","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/B978-0-12-387837-3.00016-X","article-title":"Interactions between platelets, leukocytes, and the endothelium","author":"Z Li","year":"2019","journal-title":"Platelets"},{"issue":"23","key":"ref268","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1001\/jama.1994.03510470040032","article-title":"Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra sepsis syndrome study group","volume":"271","author":"C J Fisher Jr","year":"1994","journal-title":"JAMA"},{"issue":"07","key":"ref269","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/CIRCULATIONAHA.118.033942","article-title":"Platelet serotonin aggravates myocardial ischemia\/reperfusion injury via neutrophil degranulation","volume":"139","author":"M Mauler","year":"2019","journal-title":"Circulation"},{"issue":"01","key":"ref270","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1160\/TH11-06-0443","article-title":"Acidosis downregulates platelet haemostatic functions and promotes neutrophil proinflammatory responses mediated by platelets","volume":"107","author":"J Etulain","year":"2012","journal-title":"Thromb Haemost"},{"issue":"04","key":"ref271","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.4049\/jimmunol.1400091","article-title":"Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue","volume":"193","author":"E D Hottz","year":"2014","journal-title":"J Immunol"},{"issue":"06","key":"ref272","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1186\/s13075-014-0478-0","article-title":"Platelets induce a proinflammatory phenotype in monocytes via the CD147 pathway in rheumatoid arthritis","volume":"16","author":"M Y Rong","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"01","key":"ref273","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1182\/blood.V88.1.146.146","article-title":"Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b\/CD18","volume":"88","author":"T G Diacovo","year":"1996","journal-title":"Blood"},{"key":"ref274","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1182\/asheducation-2009.1.127","article-title":"Hemophagocytic lymphohistiocytosis (HLH) and related disorders","volume":"127\u2013131","author":"A H Filipovich","year":"2009","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"issue":"02","key":"ref275","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000339857","article-title":"Cytokine secretion from human monocytes potentiated by P-selectin-mediated cell adhesion","volume":"160","author":"J Suzuki","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"issue":"06","key":"ref276","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/j.1538-7836.2008.02956.x","article-title":"Tissue factor and IL8 production by P-selectin-dependent platelet-monocyte aggregates in whole blood involves phosphorylation of Lyn and is inhibited by IL10","volume":"6","author":"C Christersson","year":"2008","journal-title":"J Thromb Haemost"},{"issue":"02","key":"ref277","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/SHK.0000000000001619","article-title":"Platelet-monocyte aggregates: understanding mechanisms and functions in sepsis","volume":"55","author":"G Fu","year":"2021","journal-title":"Shock"},{"issue":"04","key":"ref278","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1093\/ibd\/izx106","article-title":"Inverse association between circulating monocyte-platelet complexes and inflammation in ulcerative colitis patients","volume":"24","author":"C Zamora","year":"2018","journal-title":"Inflamm Bowel Dis"},{"issue":"11","key":"ref279","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1055\/s-0038-1673342","article-title":"Monocytes of different subsets in complexes with platelets in patients with myocardial infarction","volume":"118","author":"M Loguinova","year":"2018","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref280","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/ATVBAHA.122.318162","article-title":"Transfusion of adult, but not neonatal, platelets promotes monocyte trafficking in neonatal mice","volume":"43","author":"P Maurya","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2431-11-29","article-title":"Phagocytic ability of neutrophils and monocytes in neonates","volume":"11","author":"A Filias","year":"2011","journal-title":"BMC Pediatr"},{"issue":"04","key":"ref282","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1203\/01.PDR.0000180544.02537.FD","article-title":"Expression of toll-like receptors in neonatal sepsis","volume":"58","author":"D Viemann","year":"2005","journal-title":"Pediatr Res"},{"key":"ref283","first-page":"269681","article-title":"Neonatal sepsis and inflammatory mediators","volume":"2014","author":"J R Machado","year":"2014","journal-title":"Mediators Inflamm"},{"issue":"01","key":"ref284","first-page":"27","article-title":"Monocytes in neonatal bacterial sepsis","volume":"2","author":"C Doughty","year":"2022","journal-title":"Think Tank 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Immunol"},{"issue":"04","key":"ref288","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1182\/blood.V95.4.1158.004k31_1158_1166","article-title":"The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages","volume":"95","author":"B Scheuerer","year":"2000","journal-title":"Blood"},{"issue":"11","key":"ref289","doi-asserted-by":"crossref","first-page":"eaaz1580","DOI":"10.1126\/sciadv.aaz1580","article-title":"Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes","volume":"6","author":"P Han","year":"2020","journal-title":"Sci Adv"},{"issue":"11","key":"ref290","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.4049\/jimmunol.1301250","article-title":"The uncoupling of monocyte-platelet interactions from the induction of proinflammatory signaling in monocytes","volume":"191","author":"J Stephen","year":"2013","journal-title":"J Immunol"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"631285","DOI":"10.3389\/fimmu.2021.631285","article-title":"Inhibition of dendritic cell activation and modulation of T cell polarization by the platelet secretome","volume":"12","author":"A Saris","year":"2021","journal-title":"Front Immunol"},{"issue":"04","key":"ref292","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/09537104.2017.1306045","article-title":"Platelet concentrates modulate myeloid dendritic cell immune responses","volume":"29","author":"K K Ki","year":"2018","journal-title":"Platelets"},{"issue":"12","key":"ref293","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1111\/trf.14320","article-title":"Immunomodulatory effect of cryopreserved platelets: altered BDCA3+ dendritic cell maturation and activation in vitro","volume":"57","author":"K K Ki","year":"2017","journal-title":"Transfusion"},{"issue":"04","key":"ref294","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/JLB.3A0620-460RR","article-title":"Monocytes complexed to platelets differentiate into functionally deficient dendritic cells","volume":"109","author":"M V Singh","year":"2021","journal-title":"J Leukoc Biol"},{"issue":"09","key":"ref295","doi-asserted-by":"crossref","first-page":"e00186-18","DOI":"10.1128\/IAI.00186-18","article-title":"Platelets enhance dendritic cell responses against Staphylococcus aureus through CD40-CD40L","volume":"86","author":"S Nishat","year":"2018","journal-title":"Infect Immun"},{"issue":"09","key":"ref296","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/01.RES.0000070111.98158.6C","article-title":"CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation","volume":"92","author":"D P Inwald","year":"2003","journal-title":"Circ Res"},{"issue":"05","key":"ref297","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.smim.2009.05.010","article-title":"The role of CD40 and CD154\/CD40L in dendritic cells","volume":"21","author":"D Y Ma","year":"2009","journal-title":"Semin Immunol"},{"issue":"02","key":"ref298","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1365-2249.2006.03197.x","article-title":"Effect of serotonin on the differentiation of human monocytes into dendritic cells","volume":"146","author":"N Katoh","year":"2006","journal-title":"Clin Exp Immunol"},{"issue":"08","key":"ref299","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1093\/intimm\/dxg100","article-title":"Effect of CXC chemokine platelet factor 4 on differentiation and function of monocyte-derived dendritic cells","volume":"15","author":"C Q Xia","year":"2003","journal-title":"Int Immunol"},{"issue":"01","key":"ref300","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4049\/jimmunol.1602020","article-title":"CXCL4 exposure potentiates TLR-driven polarization of human monocyte-derived dendritic cells and increases stimulation of T cells","volume":"199","author":"S C Silva-Cardoso","year":"2017","journal-title":"J Immunol"},{"issue":"09","key":"ref301","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/j.ajpath.2018.05.009","article-title":"Group 2 innate lymphoid cells (ILC2s) are key mediators of the inflammatory response in polymicrobial sepsis","volume":"188","author":"T T Chun","year":"2018","journal-title":"Am J Pathol"},{"issue":"04","key":"ref302","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.jaci.2019.06.001","article-title":"Platelets attach to lung type 2 innate lymphoid cells (ILC2s) expressing P-selectin glycoprotein ligand 1 and influence ILC2 function","volume":"144","author":"M R Karta","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"03","key":"ref303","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3390\/cancers11030277","article-title":"Inhibition of NK reactivity against solid tumors by platelet-derived RANKL","volume":"11","author":"K L Clar","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"05","key":"ref304","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.4049\/jimmunol.1502658","article-title":"Platelet-derived ectosomes reduce NK cell function","volume":"197","author":"S Sadallah","year":"2016","journal-title":"J Immunol"},{"issue":"04","key":"ref305","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1159\/000323936","article-title":"Modulation of natural killer cell anti-tumor reactivity by platelets","volume":"3","author":"T Placke","year":"2011","journal-title":"J Innate 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Biol"},{"issue":"02","key":"ref309","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/imm.12854","article-title":"The biology of natural killer cells during sepsis","volume":"153","author":"Y Guo","year":"2018","journal-title":"Immunology"},{"issue":"04","key":"ref310","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.humimm.2011.01.009","article-title":"Age-related changes in natural killer cell receptors from childhood through old age","volume":"72","author":"A Almeida-Oliveira","year":"2011","journal-title":"Hum Immunol"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3389\/fimmu.2019.01590","article-title":"The human platelet as an innate immune cell: interactions between activated platelets and the complement system","volume":"10","author":"O Eriksson","year":"2019","journal-title":"Front Immunol"},{"issue":"04","key":"ref312","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1365-2141.1997.1342950.x","article-title":"The role of immunoglobulin G and fibrinogen in platelet aggregation by Streptococcus sanguis","volume":"97","author":"I Ford","year":"1997","journal-title":"Br J Haematol"},{"issue":"03","key":"ref313","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1651-2227.1990.tb11464.x","article-title":"Serum haemolytic classical and alternative pathways of complement in infancy: age-related changes","volume":"79","author":"V P Ferriani","year":"1990","journal-title":"Acta Paediatr Scand"},{"issue":"02","key":"ref314","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.imbio.2011.07.027","article-title":"Off to a slow start: under-development of the complement system in term newborns is more substantial following premature birth","volume":"217","author":"E P McGreal","year":"2012","journal-title":"Immunobiology"},{"issue":"02","key":"ref315","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4049\/jimmunol.1200580","article-title":"Platelets present antigen in the context of MHC class I","volume":"189","author":"L M Chapman","year":"2012","journal-title":"J Immunol"},{"issue":"01","key":"ref316","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"C Th\u00e9ry","year":"2018","journal-title":"J Extracell Vesicles"},{"key":"ref317","doi-asserted-by":"crossref","first-page":"24692","DOI":"10.3402\/jev.v3.24692","article-title":"Isolation and characterization of platelet-derived extracellular vesicles","volume":"3","author":"M T Aatonen","year":"2014","journal-title":"J Extracell Vesicles"},{"key":"ref318","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40560-018-0340-6","article-title":"Role of extracellular vesicles in the development of sepsis-induced coagulopathy","volume":"6","author":"T Iba","year":"2018","journal-title":"J Intensive Care"},{"key":"ref319","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fimmu.2018.00721","article-title":"Extracellular vesicles: packages sent with complement","volume":"9","author":"E Karasu","year":"2018","journal-title":"Front Immunol"},{"issue":"01","key":"ref320","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1038\/s41598-018-27190-x","article-title":"A system of cytokines encapsulated in extracellular vesicles","volume":"8","author":"W Fitzgerald","year":"2018","journal-title":"Sci Rep"},{"issue":"05","key":"ref321","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3109\/09537104.2014.932339","article-title":"CD40L expression in plasma of volunteers following LPS administration: a comparison between assay of CD40L on platelet microvesicles and soluble CD40L","volume":"26","author":"F Mobarrez","year":"2015","journal-title":"Platelets"},{"issue":"11","key":"ref322","doi-asserted-by":"crossref","first-page":"6543","DOI":"10.4049\/jimmunol.1002788","article-title":"Microparticles (ectosomes) shed by stored human platelets downregulate macrophages and modify the development of dendritic cells","volume":"186","author":"S Sadallah","year":"2011","journal-title":"J Immunol"},{"issue":"06","key":"ref323","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/cc6176","article-title":"Platelet-derived exosomes from septic shock patients induce myocardial dysfunction","volume":"11","author":"L C Azevedo","year":"2007","journal-title":"Crit Care"},{"issue":"04","key":"ref324","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.3390\/ijms22041926","article-title":"Qualitative and quantitative comparison of plasma exosomes from 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