{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:22:17Z","timestamp":1789024937351,"version":"build-2803163510"},"reference-count":105,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bleeding complications are a frequent and clinically significant problem in patients with chronic kidney disease (CKD), with prevalence increasing as kidney function declines, and in those receiving dialysis. The bleeding tendency in CKD is multifactorial: arising from platelet dysfunction, uremic\/inflammatory states, renal anemia, and the common concurrent use of anticoagulants in this population. Together, these mechanisms all contribute to impairment in hemostasis and increased risk of both spontaneous and procedural-hemorrhages. Current bleeding risk assessment tools perform poorly in the CKD population, limiting their utility for guiding clinical decision-making. Emerging evidence suggests that albuminuria, as an independent marker for both renal dysfunction and hemorrhage risk, may improve bleeding risk stratification in this cohort. This review summarizes the pathophysiological mechanisms underlying bleeding in CKD and the impact of dialysis and declining renal function. It also highlights the unmet need for more accurate, CKD-specific bleeding risk assessment tools.<\/jats:p>","DOI":"10.1055\/a-2731-2487","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T23:50:18Z","timestamp":1761609018000},"page":"645-652","source":"Crossref","is-referenced-by-count":1,"title":["Bleeding in Patients with Renal Impairment: A Current Perspective"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6828-1956","authenticated-orcid":false,"given":"Robyn","family":"Haysom","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, University Hospitals of North Midlands, Stoke-on-Trent, United Kingdom"},{"name":"University of Manchester, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadir","family":"Aziz","sequence":"additional","affiliation":[{"name":"University of Manchester, Manchester, United Kingdom"},{"name":"Department of Gastroenterology, University Hospital Coventry and Warwickshire, Coventry, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Swan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Austin Health, Heidelberg, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jecko","family":"Thachil","sequence":"additional","affiliation":[{"name":"Haematology Department, University of Manchester, Manchester, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/j.1523-1755.2005.00365.x","article-title":"Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"67","author":"A S Levey","year":"2005","journal-title":"Kidney 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