{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:21:00Z","timestamp":1771305660150,"version":"3.50.1"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Das heredit\u00e4re diffuse Magenkarzinom (HDGC) infolge krankheitsverursachender Varianten in CDH1 oder CTNNA1 sowie die famili\u00e4re adenomat\u00f6se Polyposis (FAP, krankheitsverursachende Varianten in APC) erfordern individuelle Strategien zur Krebspr\u00e4vention. Beim HDGC wird eine prophylaktische totale Gastrektomie empfohlen, w\u00e4hrend bei FAP-Patienten die endoskopische \u00dcberwachung mit Interventionen im Vordergrund steht. Die Wahl der Rekonstruktion (Roux-en-Y, Jejunuminterposition, Double-Tract) beeinflusst sowohl die M\u00f6glichkeit zur endoskopischen \u00dcberwachung des Duodenums als auch die Lebensqualit\u00e4t. Entscheidungen \u00fcber \u00dcberwachung vs. Operation sollten patientenbezogen unter Abw\u00e4gung von Krebsrisiko und postoperativer Lebensqualit\u00e4t erfolgen.<\/jats:p>","DOI":"10.1055\/a-2731-7680","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:14:24Z","timestamp":1764202464000},"page":"27-33","source":"Crossref","is-referenced-by-count":1,"title":["Pr\u00e4ventive Magenchirurgie bei heredit\u00e4rem Magenkarzinom und genetischer Pr\u00e4disposition"],"prefix":"10.1055","volume":"151","author":[{"given":"Hannah","family":"Lee","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Stein","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Heiliger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"von Frankenberg","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Hoefele","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Humangenetik, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslaw","family":"Bik-Multanowski","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Humangenetik, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Werner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie, LMU Klinikum, M\u00fcnchen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1136\/egastro-2023-100017","article-title":"Pioneering use of genetic analysis for CDH1 to identify candidates for prophylactic total gastrectomy to prevent hereditary diffuse gastric cancer","volume":"1","author":"F Mokhtari-Esbuie","year":"2023","journal-title":"eGastroenterology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"166","DOI":"10.32074\/1591-951X-166","article-title":"Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes","volume":"112","author":"I Gullo","year":"2020","journal-title":"Pathologica"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e386","DOI":"10.1016\/S1470-2045(20)30219-9","article-title":"Hereditary diffuse gastric cancer: updated clinical practice guidelines","volume":"21","author":"VR Blair","year":"2020","journal-title":"Lancet Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znae070","article-title":"Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision","volume":"111","author":"G Zaffaroni","year":"2024","journal-title":"Br J Surg"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cgh.2007.11.018","article-title":"Fundic gland polyp dysplasie is commin in familial adenomatous poylposis","volume":"6","author":"LK Binachi","year":"2008","journal-title":"Clin Gastroenterolo Hepatol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10689-017-9971-3","article-title":"Gastric cancer in FAP: a concerning rise in incidence","volume":"16","author":"G Mankaney","year":"2017","journal-title":"Fam Cancer"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1097\/DCR.0000000000001157","article-title":"Risk Factors Associated With Pouch Adenomas in Patients With Familial Adenomatous Polyposis","volume":"61","author":"P Ganschow","year":"2018","journal-title":"Dis Colon Rectum"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2022.101800","article-title":"Familial and hereditary gastric cancer, an overview","volume":"5859","author":"F Carneiro","year":"2022","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jmedgenet-2019-106346","article-title":"Redefinition of familial intestinal gastric cancer: clinical and genetic perspectives","volume":"58","author":"J Carvalho","year":"2021","journal-title":"J Med Genet"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.surg.2010.07.005","article-title":"Prophylactic total gastrectomy for individuals with germline CDH1 mutation","volume":"149","author":"PK Pandalai","year":"2011","journal-title":"Surgery"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1097\/CEJ.0000000000000805","article-title":"Controversies and strengths in prophylactic total gastrectomy for germline CDH1 pathogenic variant carriers","volume":"32","author":"JL Davis","year":"2023","journal-title":"Eur J Cancer Prev"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2025.7006","article-title":"Advancing the Evaluation and Management of CDH1-Associated Gastric Cancer","volume":"23","author":"BA Lerner","year":"2025","journal-title":"J Natl Compr Canc Netw"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10689-025-00462-y","article-title":"Guidelines for Familial Adenomatous Polyposis (FAP): challenges in defining clinical management for a rare disease","volume":"24","author":"B Zare","year":"2025","journal-title":"Fam Cancer"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1001\/jamasurg.2020.3356","article-title":"Indications for Total Gastrectomy in CDH1 Mutation Carriers and Outcomes of Risk-Reducing Minimally Invasive and Open Gastrectomies","volume":"155","author":"EL Vos","year":"2020","journal-title":"JAMA Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1055\/a-0646-4382","article-title":"Outcomes after Prophylactic Total Gastrectomy for Hereditary Diffuse Gastric Cancer","volume":"145","author":"D Pantelis","year":"2020","journal-title":"Zentralbl Chir"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1097\/SLA.0000000000005046","article-title":"Robotic Gastrectomy Versus Laparoscopic Gastrectomy for Gastric Cancer: A Multicenter Cohort Study of 5402 Patients in China","volume":"277","author":"ZY Li","year":"2023","journal-title":"Ann Surg"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1097\/SLA.0000000000003082","article-title":"Pouch Versus No Pouch Following Total Gastrectomy: Meta-analysis of Randomized and Non-randomized Studies","volume":"269","author":"NL Syn","year":"2019","journal-title":"Ann Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000445","article-title":"Endoscopic Surveillance of Duodenal Polyposis After Total Gastrectomy in Familial Adenomatous Polyposis","volume":"7","author":"RS Shah","year":"2020","journal-title":"ACG Case Rep J"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"225","DOI":"10.5230\/jgc.2020.20.e16","article-title":"Isoperistaltic Jejunal Loop Interposition after Total Gastrectomy for Gastric Cancer in Patients with Familial Adenomatous Polyposis","volume":"20","author":"M Zuin","year":"2020","journal-title":"J Gastric Cancer"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"E18","DOI":"10.3978\/j.issn.2078-6891.2013.053","article-title":"Total gastrectomy with isoperistaltic jejunal interposition flap for symptomatic management of gastric polyposis from familial adenomatous polyposis","volume":"5","author":"D Srinivasa","year":"2014","journal-title":"J Gastrointest Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4103\/jmas.jmas_161_23","article-title":"Jejunal flap interposition after total gastrectomy in managing patients with familial adenomatous polyposis: A report on the experience of a single centre","volume":"21","author":"J Barbosa","year":"2025","journal-title":"J Minim Access Surg"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1002\/jso.27084","article-title":"Short and long-term outcomes of prophylactic total gastrectomy in 54 consecutive individuals with germline pathogenic mutations in the CDH1 gene","volume":"126","author":"MD Stillman","year":"2022","journal-title":"J Surg Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1007\/s001040050270","article-title":"Kalzium and bone metabolism after gastrectomy","volume":"68","author":"TT Zittel","year":"1997","journal-title":"Chirurg"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00198-019-05220-2","article-title":"The change of bone mineral density and bone metabolism after gastrectomy for gastric cancer: a meta-analysis","volume":"31","author":"HJ Oh","year":"2020","journal-title":"Osteoporos Int"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.jamcollsurg.2010.07.003","article-title":"Large-scale investigation into dumping syndrome after gastrectomy for gastric cancer","volume":"211","author":"S Mine","year":"2010","journal-title":"J Am Coll Surg"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.gassur.2023.12.015","article-title":"Roux-en-Y with or without jejunal J-pouch reconstruction after total gastrectomy for gastric cancer: systematic review and meta-analysis of long-term functional outcomes","volume":"28","author":"M Realis Luc","year":"2024","journal-title":"J Gastrointest Surg"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1159\/000445188","article-title":"Nutrition in Patients with Gastric Cancer: An Update","volume":"2","author":"R Rosania","year":"2016","journal-title":"Gastrointest Tumors"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"728","DOI":"10.3390\/cancers14030728","article-title":"Surgery for Hereditary Diffuse Gastric Cancer: Long-Term Outcomes","volume":"14","author":"JD Forrester","year":"2022","journal-title":"Cancers (Basel)"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1007\/s11605-016-3287-8","article-title":"Prophylactic Total Gastrectomy: a Prospective Cohort Study of Long-Term Impact on Quality of Life","volume":"20","author":"J Muir","year":"2016","journal-title":"J Gastrointest Surg"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1097\/SLA.0000000000000446","article-title":"The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study","volume":"260","author":"E Worster","year":"2014","journal-title":"Ann Surg"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"473","DOI":"10.3390\/cancers16030473","article-title":"A Systematic Review on Clinical and Health-Related Quality of Life Outcomes following Total Gastrectomy in Patients with Hereditary Diffuse Gastric Cancer","volume":"16","author":"HJ Lim","year":"2024","journal-title":"Cancers (Basel)"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.21037\/tgh.2017.03.12","article-title":"Decision making, quality of life and prophylactic gastrectomy in carriers of pathogenic CDH1 mutations","volume":"2","author":"G Roberts","year":"2017","journal-title":"Transl Gastroenterol Hepatol"}],"container-title":["Zentralblatt f\u00fcr Chirurgie - Zeitschrift f\u00fcr Allgemeine, Viszeral-, Thorax- und Gef\u00e4\u00dfchirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2731-7680.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T23:34:31Z","timestamp":1771284871000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2731-7680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":32,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,2,16]]},"published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2731-7680","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0044-409X","1438-9592"],"issn-type":[{"value":"0044-409X","type":"print"},{"value":"1438-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]}}}