{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:43:35Z","timestamp":1776210215177,"version":"3.50.1"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Es gibt deutliche Hinweise darauf, dass das Karpaltunnelsyndrom (CTS),\ninsbesondere, wenn es bilateral, rezidivierend oder bei \u00e4lteren Erwachsenen\nauftritt, h\u00e4ufig mit einer lebensgef\u00e4hrlichen Systemerkrankung, der\nTransthyretin (ATTR)-Amyloidose assoziiert ist. Es sollte daher als potenzielle\nFr\u00fchmanifestation der ATTR-Amyloidose erkannt werden und weitere Untersuchungen\nauf eine systemische ATTR-Amyloidose ansto\u00dfen. In diesem Artikel beleuchten wir\ndie Bedeutung des CTS f\u00fcr die Amyloidose und weisen auf wichtige n\u00e4chste\nSchritte in der Diagnostik hin, die bei Nachweis von Amyloid im Ligamentum carpi\ntransversum unbedingt durchgef\u00fchrt werden sollten. Diese beinhalten die\nhistopathologische Subspezfizierung, die Untersuchung auf Leichtketten im Serum\nzum Ausschluss oder der raschen Behandlung einer AL-Amyloidose und insbesondere\nbei Symptomen einer Kardiomyopathie die Diagnostik einer kardialen Amyloidose\nsowie die genetische Testung bei Nachweis von ATTR-Amyloid. Zusammenfassend ist\ndas Karpaltunnelsyndrom ein wichtiger erster Hinweis auf eine t\u00f6dliche, aber\nbehandelbare Systemerkrankung, die nicht \u00fcbersehen werden sollte. Als\nHandchirurg sollte daher ein Augenmerk auf Patient:innen mit CTS gelegt werden\nund eine histopathologische Untersuchung des entnommenen Gewebes m\u00f6glichst in\ndie Routine integriert werden.<\/jats:p>","DOI":"10.1055\/a-2732-6576","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:12:15Z","timestamp":1766103135000},"page":"127-134","source":"Crossref","is-referenced-by-count":0,"title":["ATTR-Amyloidose f\u00fcr den Handchirurgen \u2013 eine versteckte, behandelbare\nSystemerkrankung"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8711-5526","authenticated-orcid":false,"given":"Helena Franziska","family":"Pernice","sequence":"additional","affiliation":[{"name":"Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0987-8007","authenticated-orcid":false,"given":"Sebastian","family":"Spethmann","sequence":"additional","affiliation":[{"name":"Cardiology, Charite \u2013 Universitatsmedizin Berlin, Berlin,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-0072","authenticated-orcid":false,"given":"Katrin","family":"Hahn","sequence":"additional","affiliation":[{"name":"Neurology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Campus Charite Mitte,\nBerlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1111\/jnc.15233","article-title":"Targeting transthyretin \u2013 Mechanism-based treatment approaches and future\nperspectives in hereditary amyloidosis","volume":"156","author":"M F Dohrn","year":"2021","journal-title":"J Neurochem"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/path.1759","article-title":"Amyloid deposits in transthyretin-derived amyloidosis: cleaved transthyretin is\nassociated with distinct amyloid morphology","volume":"206","author":"J Bergstrom","year":"2005","journal-title":"J Pathol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/ejhf.1742","article-title":"Carpal tunnel syndrome in cardiac amyloidosis: implications for early diagnosis\nand prognostic role across the spectrum of aetiologies","volume":"22","author":"A Milandri","year":"2020","journal-title":"Eur J Heart Fail"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s40265-022-01830-z","article-title":"Diagnosis and Treatment of AL Amyloidosis","volume":"83","author":"G Palladini","year":"2023","journal-title":"Drugs"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1080\/03007995.2017.1297930","article-title":"Disease burden of systemic light-chain amyloidosis: a systematic literature\nreview","volume":"33","author":"H M Lin","year":"2017","journal-title":"Curr Med Res Opin"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"120341","DOI":"10.1016\/j.jns.2022.120341","article-title":"Prevalence and predictors of neurological manifestations in systemic AL\namyloidosis","volume":"440","author":"A Thimm","year":"2022","journal-title":"J Neurol Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"E2403","DOI":"10.1002\/humu.22619","article-title":"Online registry for mutations in hereditary amyloidosis including nomenclature\nrecommendations","volume":"35","author":"D M Rowczenio","year":"2014","journal-title":"Hum Mutat"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1177\/2047487319877708","article-title":"Keys to early diagnosis of cardiac amyloidosis: red flags from clinical,\nlaboratory and imaging findings","volume":"27","author":"G Vergaro","year":"2020","journal-title":"Eur J Prev Cardiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1093\/brain\/75.3.408","article-title":"A peculiar form of peripheral neuropathy; 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Neurol"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1212\/cpj.0000000000000640","article-title":"Carpal tunnel syndrome and associated symptoms as first manifestation of hATTR\namyloidosis","volume":"9","author":"C Karam","year":"2019","journal-title":"Neurol Clin Pract"}],"container-title":["Handchirurgie \u00b7 Mikrochirurgie \u00b7 Plastische Chirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2732-6576.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:45:05Z","timestamp":1776206705000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2732-6576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":35,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,4,14]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2732-6576","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0722-1819","1439-3980"],"issn-type":[{"value":"0722-1819","type":"print"},{"value":"1439-3980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}