{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T08:10:49Z","timestamp":1778227849817,"version":"3.51.4"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Zu den Lungenproblemen, die bei Kindern mit Down-Syndrom und in deren weiteren Leben h\u00e4ufig auftreten, geh\u00f6ren wiederkehrende und schwerer Atemwegsinfektionen, Atemwegsanomalien, Lungengef\u00e4\u00dferkrankungen, zystische Lungenerkrankungen und obstruktive Schlafapnoe. Mit dem Down-Syndrom verbundene Erkrankungen wie Hypotonie, Dysphagie und Immunst\u00f6rungen k\u00f6nnen die wiederkehrenden Atemwegsproblemen aggravieren. Daher sollten bei Kindern und Erwachsenen mit Down-Syndrom und rezidivierenden bronchopulmonalen Symptomen diese Krankheitsbilder ber\u00fccksichtigt und ad\u00e4quat behandelt werden. Das mit diesen bronchopulmonalen Erkrankungen einhergehende, erh\u00f6hte Morbidit\u00e4ts- und Mortalit\u00e4tsrisiko wird durch weitere Komorbidit\u00e4ten, wie z.B. Adipositas, koronare Herzkrankheit, Magen-Darm-Erkrankungen oder perioperative Komplikationen, zus\u00e4tzlich erh\u00f6ht. Die hohe Rate an Aspirationspneumonien macht es dringend erforderlich, bei allen Menschen mit Down-Syndrom konsequent eine ggfs. vorliegende Dysphagie abzukl\u00e4ren und ggf. pr\u00e4ventive Ma\u00dfnahmen (wie z.B. Mundpflege und Schlucktraining) anzuwenden.Angesichts der Komplexit\u00e4t mancher pulmonalen Krankheiten beim Down-Syndrom, wie z.B. der pulmonalen Hypertonie, empfiehlt sich die Therapie in spezialisierten Zentren.Die Entwicklung spezifischer medizinischer Versorgungsprogramme f\u00fcr die Diagnostik und Therapie der Lungen- und Atemwegserkrankungen bei Personen mit Down-Syndrom ist von zentraler Bedeutung.<\/jats:p>","DOI":"10.1055\/a-2733-3375","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:47:58Z","timestamp":1762904878000},"page":"360-366","source":"Crossref","is-referenced-by-count":0,"title":["Atemwegs- und Lungenerkrankungen beim Down-Syndrom"],"prefix":"10.1055","volume":"80","author":[{"given":"Bernd","family":"Sch\u00f6nhofer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Pneumologie und Infektiologie der Medizinischen Hochschule Hannover, Deutschland","place":["Hannover"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"Sappok","sequence":"additional","affiliation":[{"name":"Krankenhaus Mara, Universit\u00e4tsklinik f\u00fcr Inklusive Medizin, NRW, Deutschland","place":["Bielefeld"],"department":["Universit\u00e4t Bielefeld, Medizinische Fakult\u00e4t und Universit\u00e4tsklinikum OWL"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1034\/j.1399-0004.2002.620506.x","article-title":"The changing survival pro\ufb01le of people with Down\u2019s syndrome: Implications for genetic counselling","volume":"62","author":"EJ Glasson","year":"2002","journal-title":"Clinical Genetics"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e2212910","DOI":"10.1001\/jamanetworkopen.2022.12910","article-title":"Association of Alzheimer Disease 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