{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:32:33Z","timestamp":1790332353664,"version":"4.1.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The existing literature on the effects of semaglutide in people with HIV\n                        (PWH) and diabetes mellitus remains limited. In this study, the effects of\n                        semaglutide on weight control and inflammation in PWH were evaluated.<\/jats:p>\n                  <jats:p>This is a prospective observational study that included PWH with type 2\n                        diabetes mellitus monitored at the HIV Unit of the University General\n                        Hospital of Alexandroupolis and a matched control group of non-HIV\n                        individuals. Demographic, anthropometric, and clinical characteristics,\n                        including HIV-related data and comorbidities, were reported. All\n                        participants received semaglutide with a gradual dose increase to 1 mg once\n                        weekly. Body Mass Index (BMI), glycosylated haemoglobin (HbA1c), and\n                        inflammatory markers (IL-6, TNF, hsCRP, sCD14, CD4\/CD8 ratio) were recorded\n                        at baseline and at 6, 12, 18, and 24 months.<\/jats:p>\n                  <jats:p>Fifty participants (PWH: n=25; non-HIV: n=25) were included. At baseline, the\n                        mean BMI was 35.2\u00b18.0\u2009kg\/m2 for PWH and 36.1\u00b16.0\u2009kg\/m2\n                        for non-HIV controls. Semaglutide treatment resulted in significant and\n                        sustained weight loss in both groups (p&lt;0.001). At 24 months, the median\n                        weight loss was \u201314.6 kg in the PWH group and \u201318.8 kg in the non-HIV group\n                        for those with a baseline BMI&gt;35\u2009kg\/m2. Glycemic control also\n                        improved significantly, with mean HbA1c decreasing from 7.7%\u00b11.23 to\n                        5.2%\u00b11.02 in PWH (p&lt;0.001), and from 7.9%\u00b11.16 to 5.6%\u00b11.21 in non-HIV\n                        controls (p&lt;0.001). Significant reductions were observed in hsCRP and\n                        sCD14 levels in both cohorts. A unique finding was the significant increase\n                        in the CD4\/CD8 ratio in the PWH group, from a mean baseline of 0.54\u00b10.12 to\n                        0.83\u00b10.14 at 24 months (p&lt;0.001), a change not seen in the non-HIV\n                        controls.<\/jats:p>\n                  <jats:p>Semaglutide appears to be an effective and safe option for weight reduction\n                        and inflammation control in PWHIV. Further studies with a larger number of\n                        patients are necessary to substantiate these findings.<\/jats:p>","DOI":"10.1055\/a-2737-6227","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:49:25Z","timestamp":1762300165000},"page":"29-35","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Semaglutide on Weight Loss and Inflammation in People\n                    with HIV. An Observational Prospective Study in Greek Population"],"prefix":"10.1055","volume":"134","author":[{"given":"Vasileios","family":"Petrakis","sequence":"additional","affiliation":[{"name":"2nd University Department of Internal Medicine,\n                    Department of Infectious Diseases, Democritus University of Thrace, General\n                    University Hospital of Alexandroupolis, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Rafailidis","sequence":"additional","affiliation":[{"name":"2nd University Department of Internal Medicine,\n                    Department of Infectious Diseases, University General Hospital Alexandroupolis,\n                    Democritus University Thrace, General University Hospital of Evros Sector of\n                    Alexandroupolis, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Panopoulou","sequence":"additional","affiliation":[{"name":"Univeristy Laboratory of Microbiology, Democritus\n                    University Thrace, General University Hospital of Evros Sector of\n                    Alexandroupolis, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theocharis","family":"Konstantinidis","sequence":"additional","affiliation":[{"name":"Univeristy Laboratory of Microbiology, Democritus\n                    University Thrace, General University Hospital of Evros Sector of\n                    Alexandroupolis, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0759","authenticated-orcid":false,"given":"Andreas G.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit, School of\n                    Medicine, National and Kapodistrian University of Athens, Panepistemiako Geniko\n                    Nosokomeio Attikon, Athens, Greece"},{"name":"Microbiology Department, Agios Savvas General Cancer and\n                    Oncology Hospital of Athens, Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikoleta","family":"Babaka","sequence":"additional","affiliation":[{"name":"2nd University Department of Internal Medicine,\n                    Department of Infectious Diseases, University General Hospital Alexandroupolis,\n                    Democritus University Thrace, General University Hospital of Evros Sector of\n                    Alexandroupolis, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Papazoglou","sequence":"additional","affiliation":[{"name":"2nd University Department of Internal Medicine,\n                    Department of Infectious Diseases, University General Hospital Alexandroupolis,\n                    Democritus University Thrace, General University Hospital of Evros Sector of\n                    Alexandroupolis, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Periklis","family":"Panagopoulos","sequence":"additional","affiliation":[{"name":"2nd University Department of Internal Medicine,\n                    Department of Infectious Diseases, University General Hospital Alexandroupolis,\n                    Democritus University Thrace, General University Hospital of Evros Sector of\n                    Alexandroupolis, Alexandroupolis, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1001\/jama.2012.7961","article-title":"Antiretroviral treatment of adult HIV infection: 2012 Recommendations of the\n                    International Antiviral 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HIV","volume":"14","author":"C O Hileman","year":"2017","journal-title":"Curr HIV\/AIDS Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3389\/fendo.2018.00514","article-title":"Insulin resistance in HIV-patients: Causes and consequences","volume":"9","author":"M N Pedro","year":"2018","journal-title":"Front Endocrinol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3390\/idr16050066","article-title":"Atherosclerosis and cardiovascular complications in people living with HIV: A\n                    focused review","volume":"16","author":"M S Patern\u00f2 Raddusa","year":"2024","journal-title":"Infect Dis Rep"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"670566","DOI":"10.3389\/fimmu.2021.670566","article-title":"Contribution of adipose tissue to the chronic immune activation and inflammation\n                    associated with HIV infection and its treatment","volume":"12","author":"C Bourgeois","year":"2021","journal-title":"Front Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMoa2032183","article-title":"Once-weekly semaglutide in adults with overweight or obesity","volume":"384","author":"JP H Wilding","year":"2021","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1007\/s12325-021-01710-0","article-title":"Weight loss and maintenance related to the mechanism of action of glucagon-like\n                    peptide 1 receptor agonists","volume":"38","author":"J Ard","year":"2021","journal-title":"Adv Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1007\/s13340-024-00744-3","article-title":"Effects of weight loss from oral semaglutide administration on cardiometabolic\n                    risk factors in Japanese patients with type 2 diabetes: A retrospective analysis\n                    using propensity score matching","volume":"15","author":"K Aoyama","year":"2024","journal-title":"Diabetol Int"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2006.01.004","article-title":"The biology of incretin hormones","volume":"3","author":"D J Drucker","year":"2006","journal-title":"Cell Metab"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S2213-8587(24)00150-5","article-title":"Once-weekly semaglutide in people with HIV-associated lipohypertrophy: A\n                    randomised, double-blind, placebo-controlled phase 2b single-centre clinical\n                    trial","volume":"12","author":"A R Eckard","year":"2024","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6546","DOI":"10.3390\/ijms26146546","article-title":"Lipodystrophy in HIV: Evolving challenges and unresolved questions","volume":"26","author":"M Giralt","year":"2025","journal-title":"Int J Mol 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CD4\/CD8 ratio normalisation and non-AIDS-related\n                    events in individuals with HIV who achieve viral load suppression with\n                    antiretroviral therapy: An observational cohort study","volume":"2","author":"C Mussini","year":"2015","journal-title":"Lancet HIV"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2737-6227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:17:34Z","timestamp":1772756254000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2737-6227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":26,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,3,5]]},"published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2737-6227","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11,4]]},"published":{"date-parts":[[2025,11,4]]}}}