{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:26:39Z","timestamp":1764203199426,"version":"3.46.0"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endoscopic transmural drainage with subsequent endoscopic necrosectomy (EN) has become the first-line treatment for acute necrotizing pancreatitis with walled-off necrosis (WON). There is a growing interest in incorporating EN at the index intervention; however, data about the safety of EN are limited. This case series evaluated the rate and type of adverse events (AEs) associated with EN.<\/jats:p>\n                  <jats:p>We retrospectively included consecutive patients with WON from 2012 to 2024 who underwent EN in our tertiary referral center. An AE was defined as any event leading to premature cessation of necrosectomy or requiring intervention either during the procedure or within 24 hours of the procedure.<\/jats:p>\n                  <jats:p>A total of 235 patients and 880 EN procedures (median: 3, interquartile range: 2\u20135) were recorded. The median age of patients was 57.5 years, of whom 116 were female (49.3%). Snares were used in most procedures (90.9%), EndoRotor in 4.3%, and both were used in 4.8% of procedures. A total of 14 AEs (1.6%) were identified in 11 different patients (4.7%): 13 bleeds and one pneumoperitoneum. In-hospital mortality was significantly higher in the AE group (45.5%) than in the non-AE group (10.3%, P = 0.0004).<\/jats:p>\n                  <jats:p>AEs are rare in EN but are associated with increased mortality.<\/jats:p>","DOI":"10.1055\/a-2737-6307","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:48:59Z","timestamp":1762300139000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Endoscopic necrosectomy is safe in patients with pancreatic walled-off necrosis: Insights from a tertiary center study of 880 procedures"],"prefix":"10.1055","volume":"13","author":[{"given":"Julie Falkebo","family":"Jensen","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Stinne Timmner","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Hadi","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Feldager","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"August Pilegaard","family":"Prahm","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ebrahim","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4453-4624","authenticated-orcid":false,"given":"Gitte Aabye","family":"Olsen","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stine","family":"Roug","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srdan","family":"Novovic","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9333-0399","authenticated-orcid":false,"given":"John G\u00e1sdal","family":"Karstensen","sequence":"additional","affiliation":[{"name":"Gastro Unit, Hvidovre Hospital, Hvidovre, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"PA Banks","year":"2013","journal-title":"Gut"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e386","DOI":"10.1097\/MPA.0000000000002314","article-title":"Prediction of admission to intensive care unit and 1-year mortality after acute pancreatitis with walled-off pancreatic necrosis: A retrospective, single-center cohort study","volume":"53","author":"M Ebrahim","year":"2024","journal-title":"Pancreas"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/gutjnl-2017-314657","article-title":"Dutch Pancreatitis Study Group. Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis","volume":"68","author":"NJ Schepers","year":"2019","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1055\/a-0588-5365","article-title":"Endoscopic management of acute necrotizing pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) evidence-based multidisciplinary guidelines","volume":"50","author":"M Arvanitakis","year":"2018","journal-title":"Endoscopy"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.pan.2013.07.063","article-title":"IAP\/APA evidence-based guidelines for the management of acute pancreatitis","volume":"13","author":"Working Group IAP\/APA Acute Pancreatitis Guidelines","year":"2013","journal-title":"Pancreatology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/S2468-1253(23)00331-X","article-title":"United States Pancreatic Disease Study Group. Upfront endoscopic necrosectomy or step-up endoscopic approach for infected necrotising pancreatitis (DESTIN): a single-blinded, multicentre, randomised trial","volume":"9","author":"JY Bang","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.gie.2023.10.044","article-title":"Novel powered 5.0-mm endoscopic debridement catheter for endoscopic transmural necrosectomy of pancreatic walled-off necrosis: a case series of consecutive patients from a tertiary referral center (with video)","volume":"99","author":"GA Olsen","year":"2024","journal-title":"Gastrointest Endosc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.gie.2021.11.038","article-title":"Novel classification for adverse events in GI endoscopy: the AGREE classification","volume":"95","author":"KJ Nass","year":"2022","journal-title":"Gastrointest Endosc"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1136\/gutjnl-2022-328225","article-title":"EUS-guided drainage of large walled-off pancreatic necroses using plastic versus lumen-apposing metal stents: A single-centre randomised controlled trial","volume":"72","author":"JG Karstensen","year":"2022","journal-title":"Gut"}],"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2737-6307.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:22:40Z","timestamp":1764202960000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2737-6307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":9,"journal-issue":{"issue":"CP","published-online":{"date-parts":[[2025,1,7]]},"published-print":{"date-parts":[[2025]]}},"alternative-id":["a27376307"],"URL":"https:\/\/doi.org\/10.1055\/a-2737-6307","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"type":"print","value":"2364-3722"},{"type":"electronic","value":"2196-9736"}],"subject":[],"published-other":{"date-parts":[[2025,11,4]]},"published":{"date-parts":[[2025,11,4]]}}}