{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T01:02:07Z","timestamp":1784941327305,"version":"3.55.0"},"reference-count":120,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cervical artery dissection is one of the leading causes of ischemic stroke in young adults, and poses unique diagnostic and therapeutic challenges due to an often nonspecific clinical presentation. Prompt recognition is essential, as early ischemic events are common within the first 2 to 4 weeks. This review summarizes current evidence on the epidemiology, pathophysiology, clinical features, diagnostic strategies, and management of cervical carotid artery dissections. While antithrombotic therapy is the mainstay of secondary stroke prevention, the optimal choice between antiplatelet and anticoagulation remains uncertain. Randomized trials and large cohort studies suggest similar efficacy between antiplatelet and anticoagulant therapies, though anticoagulation may confer benefit in patients with vessel occlusion. Recurrent dissection and ischemic events are rare, and dissecting aneurysms generally have a benign course. Endovascular intervention is reserved for select cases. A tailored, risk-based approach to therapy\u2014guided by clinical and radiographic features\u2014is essential to improve outcomes in this complex and heterogeneous population.<\/jats:p>","DOI":"10.1055\/a-2737-7618","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:07:34Z","timestamp":1762474054000},"page":"381-390","source":"Crossref","is-referenced-by-count":0,"title":["Carotid Dissection: Pathophysiology and Treatment"],"prefix":"10.1055","volume":"46","author":[{"given":"Ekaterina","family":"Bakradze","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Yaghi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Brown University, Providence, Rhode Island, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1161\/STR.0000000000000457","article-title":"Treatment and outcomes of cervical artery dissection in adults: a scientific statement from the American Heart Association","volume":"55","author":"S Yaghi","year":"2024","journal-title":"Stroke"},{"issue":"956","key":"ref2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/pgmj.2003.016774","article-title":"Carotid and vertebral artery dissection syndromes","volume":"81","author":"B Thanvi","year":"2005","journal-title":"Postgrad Med J"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/STROKEAHA.122.040524","article-title":"Risk factors and causes of ischemic stroke in 1322 young adults","volume":"54","author":"M S Ekker","year":"2023","journal-title":"Stroke"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1212\/01.wnl.0000244486.30455.71","article-title":"Incidence and outcome of cervical artery dissection: a population-based study","volume":"67","author":"V H Lee","year":"2006","journal-title":"Neurology"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1212\/01.wnl.0000237341.30854.6a","article-title":"Gender differences in spontaneous cervical artery dissection","volume":"67","author":"M Arnold","year":"2006","journal-title":"Neurology"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1212\/01.WNL.0000094325.95097.86","article-title":"Risk of stroke and recurrent dissection after a cervical artery dissection: a multicenter study","volume":"61","author":"E Touz\u00e9","year":"2003","journal-title":"Neurology"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1136\/jnnp.2005.077073","article-title":"Seasonal variability in spontaneous cervical artery dissection","volume":"77","author":"M Paciaroni","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"07","key":"ref8","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S1474-4422(09)70084-5","article-title":"Cervical-artery dissections: predisposing factors, diagnosis, and outcome","volume":"8","author":"S Debette","year":"2009","journal-title":"Lancet Neurol"},{"issue":"09","key":"ref9","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1136\/jnnp.2006.094359","article-title":"Pain as the only symptom of cervical artery dissection","volume":"77","author":"M Arnold","year":"2006","journal-title":"J Neurol Neurosurg 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Biller","year":"2014","journal-title":"Stroke"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1358863X18811596","article-title":"High incidence and clinical characteristics of fibromuscular dysplasia in patients with spontaneous cervical artery dissection: the ARCADIA-POL study","volume":"24","author":"P Talarowska","year":"2019","journal-title":"Vasc Med"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jacc.2016.04.044","article-title":"Dissection and aneurysm in patients with fibromuscular dysplasia: findings from the U.S. Registry for FMD","volume":"68","author":"D Kadian-Dodov","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00415-003-0174-5","article-title":"Cervical artery dissection\u2013clinical features, risk factors, therapy and outcome in 126 patients","volume":"250","author":"R Dziewas","year":"2003","journal-title":"J Neurol"},{"issue":"03","key":"ref19","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/STROKEAHA.120.031579","article-title":"Clinical features of patients with cervical artery dissection and fibromuscular dysplasia","volume":"52","author":"S Bonacina","year":"2021","journal-title":"Stroke"},{"issue":"02","key":"ref20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1212\/CON.0000000000001233","article-title":"Cervical artery dissection","volume":"29","author":"S Salehi Omran","year":"2023","journal-title":"Continuum (Minneap Minn)"},{"issue":"07","key":"ref21","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1161\/01.STR.0000078309.56307.5C","article-title":"Infection and the risk of spontaneous cervical artery dissection: a case-control study","volume":"34","author":"B 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Shu","year":"2024","journal-title":"Neurology"},{"issue":"05","key":"ref43","doi-asserted-by":"crossref","first-page":"e039662","DOI":"10.1161\/JAHA.124.039662","article-title":"Intravenous thrombolysis in cervical artery dissection-related stroke: a nationwide study","volume":"14","author":"L Shu","year":"2025","journal-title":"J Am Heart Assoc"},{"issue":"07","key":"ref44","doi-asserted-by":"crossref","first-page":"e213465","DOI":"10.1212\/WNL.0000000000213465","article-title":"Functional outcome in patients with carotid artery dissection undergoing thrombectomy or standard medical treatment","volume":"104","author":"M Sykora","year":"2025","journal-title":"Neurology"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1161\/STROKEAHA.120.033032","article-title":"Endovascular therapy of anterior circulation tandem occlusions: pooled analysis from the TITAN and ETIS registries","volume":"52","author":"M Anadani","year":"2021","journal-title":"Stroke"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1161\/STROKEAHA.120.030038","article-title":"Safety and outcome of carotid dissection stenting during the treatment of tandem occlusions: a pooled analysis of TITAN and ETIS","volume":"51","author":"G Marnat","year":"2020","journal-title":"Stroke"},{"issue":"12","key":"ref47","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/01.STR.0000101915.11128.3D","article-title":"Emergent stenting to treat patients with carotid artery dissection: clinically and radiologically directed therapeutic decision making","volume":"34","author":"J E Cohen","year":"2003","journal-title":"Stroke"},{"issue":"01","key":"ref48","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1161\/STROKEAHA.119.027827","article-title":"Stenting for acute carotid artery dissection","volume":"51","author":"S C Brown","year":"2020","journal-title":"Stroke"},{"key":"ref49","first-page":"e001726","article-title":"Endovascular stenting for acute ischemic stroke due to cervical artery dissection: nationwide study of stroke recurrence","author":"H Chen","journal-title":"Stroke Vasc Intervent Neurol"},{"issue":"04","key":"ref50","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/STROKEAHA.124.048295","article-title":"Emergent carotid stenting during thrombectomy in tandem occlusions secondary to dissection: a STOP-CAD secondary study","volume":"56","author":"J A Sousa","year":"2025","journal-title":"Stroke"},{"issue":"03","key":"ref51","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/1747493020929948","article-title":"Effect of emergent carotid stenting during endovascular therapy for acute anterior circulation stroke patients with tandem occlusion: a multicenter, randomized, clinical trial (TITAN) protocol","volume":"16","author":"F Zhu","year":"2021","journal-title":"Int J Stroke"},{"issue":"04","key":"ref52","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1474-4422(15)70018-9","article-title":"Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial","volume":"14","author":"H S Markus","year":"2015","journal-title":"Lancet Neurol"},{"issue":"06","key":"ref53","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1001\/jamaneurol.2024.1141","article-title":"Antithrombotic treatment for cervical artery dissection: a systematic review and individual patient data meta-analysis","volume":"81","author":"J E Kaufmann","year":"2024","journal-title":"JAMA Neurol"},{"issue":"04","key":"ref54","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/23969873221111051","article-title":"Vitamin K antagonist versus novel oral anticoagulants for management of cervical artery dissection: interactive systematic review and meta-analysis","volume":"7","author":"M A Essibayi","year":"2022","journal-title":"Eur Stroke J"},{"issue":"07","key":"ref55","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1161\/STROKEAHA.124.047310","article-title":"Anticoagulation versus antiplatelets in spontaneous cervical artery dissection: a systematic review and meta-analysis","volume":"55","author":"S Yaghi","year":"2024","journal-title":"Stroke"},{"issue":"01","key":"ref56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1215340","article-title":"Clopidogrel with aspirin in acute minor stroke or transient ischemic attack","volume":"369","author":"Y Wang","year":"2013","journal-title":"N Engl J Med"},{"issue":"03","key":"ref57","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1056\/NEJMoa1916870","article-title":"Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA","volume":"383","author":"S C Johnston","year":"2020","journal-title":"N Engl J 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Laarhoven","year":"2022","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"03","key":"ref68","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ejvs.2016.03.021","article-title":"Fate of distal false aneurysms complicating internal carotid artery dissection: a systematic review","volume":"52","author":"K I Paraskevas","year":"2016","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"02","key":"ref69","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.radcr.2017.01.016","article-title":"Internal carotid artery dissection and pseudoaneurysm formation with resultant ipsilateral hypoglossal nerve palsy","volume":"12","author":"G Cruciata","year":"2017","journal-title":"Radiol Case Rep"},{"issue":"05","key":"ref70","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1227\/NEU.0b013e3181f076ac","article-title":"Carotid artery sacrifice for unclippable and uncoilable aneurysms: endovascular occlusion vs common carotid artery 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Dissection of the vertebral artery during a basketball game: a case report","volume":"44","author":"F De Giorgio","year":"2004","journal-title":"Med Sci Law"},{"issue":"01","key":"ref85","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1552-6569.2009.00387.x","article-title":"Spontaneous internal carotid artery dissection: an uncommon cause of recurrent postpartum headache","volume":"21","author":"E Stamboulis","year":"2011","journal-title":"J Neuroimaging"},{"issue":"01","key":"ref86","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/j.jemermed.2009.08.012","article-title":"Thunderclap headache with orgasm: a case of basilar artery dissection associated with sexual intercourse","volume":"43","author":"B E Delasobera","year":"2012","journal-title":"J Emerg Med"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1159\/000101470","article-title":"Fibromuscular dysplasia may herald symptomatic recurrence of cervical artery 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Debette","year":"2009","journal-title":"Stroke"},{"issue":"03","key":"ref91","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1212\/WNL.0b013e318225aad2","article-title":"Cervical arterial dissections due to segmental mediolytic arteriopathy","volume":"77","author":"T Fantaneanu","year":"2011","journal-title":"Neurology"},{"issue":"01","key":"ref92","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1552-6569.2001.tb00010.x","article-title":"Vertebral artery dissection in Turner's syndrome: diagnosis by magnetic resonance imaging","volume":"11","author":"P Muscat","year":"2001","journal-title":"J Neuroimaging"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1212\/WNL.96.15_supplement.2752","article-title":"A case of spontaneous triple vessel dissection in Turner syndrome (2752)","volume":"96","author":"A Nguyen","year":"2021","journal-title":"Neurology"},{"issue":"03","key":"ref94","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000093579","article-title":"Bilateral internal carotid artery dissection in cystathionine beta-synthase deficiency","volume":"55","author":"N Weiss","year":"2006","journal-title":"Eur Neurol"},{"issue":"03","key":"ref95","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000201559","article-title":"Spontaneous cervical artery dissection in adult Williams syndrome","volume":"27","author":"P Vanacker","year":"2009","journal-title":"Cerebrovasc Dis"},{"issue":"10","key":"ref96","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.05.028","article-title":"Vertebral artery dissection in patients with autosomal dominant polycystic kidney disease","volume":"23","author":"T Kuroki","year":"2014","journal-title":"J Stroke Cerebrovasc 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Vila","year":"2003","journal-title":"Stroke"},{"issue":"09","key":"ref100","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1212\/WNL.0b013e3182a2cbe2","article-title":"Reversible cerebral vasoconstriction syndrome and cervical artery dissection in 20 patients","volume":"81","author":"J Mawet","year":"2013","journal-title":"Neurology"},{"issue":"07","key":"ref101","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1161\/01.STR.0000169919.73219.30","article-title":"A systematic review of the risk factors for cervical artery dissection","volume":"36","author":"S M Rubinstein","year":"2005","journal-title":"Stroke"},{"issue":"10","key":"ref102","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.CIR.95.10.2351","article-title":"Aortic root dilatation in patients with spontaneous cervical artery dissection","volume":"95","author":"C Tzourio","year":"1997","journal-title":"Circulation"},{"issue":"10","key":"ref103","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1161\/STROKEAHA.116.013736","article-title":"Vascular tortuosity may be associated with cervical artery dissection","volume":"47","author":"B J Kim","year":"2016","journal-title":"Stroke"},{"issue":"02","key":"ref104","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/STROKEAHA.124.049046","article-title":"Cervical artery tortuosity is associated with dissection occurrence and late recurrence: a nested case-control study","volume":"56","author":"L Mayer-Suess","year":"2025","journal-title":"Stroke"},{"issue":"01","key":"ref105","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/WCO.0b013e32835c607f","article-title":"Shared associations of nonatherosclerotic, large-vessel, cerebrovascular arteriopathies: considering intracranial aneurysms, cervical artery dissection, moyamoya disease and fibromuscular 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