{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:03:51Z","timestamp":1772150631489,"version":"3.50.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Leukemic infiltration of the lungs is rarely reported in children. Clinical\n                    symptoms are often variable and nonspecific, making diagnosis challenging. The\n                    actual frequency of pulmonary involvement, the severity of local findings, and\n                    typical imaging characteristics in pediatric patients remain largely unclear.\n                    Most literature studies on the radiological features of leukemic lung\n                    infiltration have focused on adults, leaving a significant gap in pediatric\n                    data. This lack of information can hinder clinical and radiological assessment\n                    in children. Here, we present a case of leukemic pulmonary infiltration in an\n                    adolescent with nonspecific symptoms and markedly abnormal computed tomographic\n                    findings. We describe the morphological abnormalities, discuss differential\n                    diagnoses, and review the limited literature on pulmonary involvement in\n                    childhood leukemia. Further studies are needed to better characterize the\n                    frequency, types, and imaging features of leukemic pulmonary infiltration in\n                    children.<\/jats:p>","DOI":"10.1055\/a-2738-7397","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:02:42Z","timestamp":1765324962000},"page":"74-78","source":"Crossref","is-referenced-by-count":0,"title":["ALL Figured Out? Primary Leukemic Pulmonary Infiltration in an\n                    Adolescent with Acute Lymphoblastic Leukemia: A Case Report and a Brief Review\n                    of the Literature"],"prefix":"10.1055","volume":"238","author":[{"given":"Rachel","family":"Bortnick","sequence":"additional","affiliation":[{"name":"Pediatrics, Paracelsus Medical University, Salzburg,\n                    Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herwig","family":"Brandtner","sequence":"additional","affiliation":[{"name":"Radiology, Paracelsus Medical University, Salzburg,\n                    Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Vasilico","sequence":"additional","affiliation":[{"name":"Pediatrics, Paracelsus Medical University, Salzburg,\n                    Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Basek","sequence":"additional","affiliation":[{"name":"Pediatrics, Paracelsus Medical University, Salzburg,\n                    Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Grewendorf","sequence":"additional","affiliation":[{"name":"Pediatrics, Paracelsus Medical University, Salzburg,\n                    Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1055\/s-2005-922034","article-title":"Myeloid leukemias and lung involvement","volume":"26","author":"T T Koh","year":"2005","journal-title":"Semin Respir Crit Care Med"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1148\/rg.2019180069","article-title":"Leukemic Involvement in the Thorax","volume":"39","author":"G S Shroff","year":"2019","journal-title":"Radiographics"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/1097-0142(197907)44:1<264::AID-CNCR2820440144>3.0.CO;2-G","article-title":"Respiratory distress of hyperleukocytic granulocytic leukemias","volume":"44","author":"J P Vernant","year":"1979","journal-title":"Cancer"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1378\/chest.98.5.1233","article-title":"Pulmonary complications of leukemia","volume":"98","author":"F L Hildebrand","year":"1990","journal-title":"Chest"},{"issue":"16","key":"ref5","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1200\/JCO.2007.15.0177","article-title":"Guidelines for the management of pediatric and adult tumor lysis syndrome: an\n                    evidence-based review","volume":"26","author":"B Coiffier","year":"2008","journal-title":"J Clin Oncol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.hemonc.2014.09.003","article-title":"Secondary pulmonary alveolar proteinosis in hematologic malignancies","volume":"7","author":"C P Chaulagain","year":"2014","journal-title":"Hematol Oncol Stem Cell Ther"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/RTI.0b013e3181930ed6","article-title":"Secondary pulmonary alveolar proteinosis: a confusing and potentially serious\n                    complication of hematologic malignancy","volume":"24","author":"J H Chung","year":"2009","journal-title":"J Thorac Imaging"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2169\/internalmedicine.56.6920","article-title":"GM-CSF Autoantibody-positive Pulmonary Alveolar Proteinosis with Simultaneous\n                    Myeloproliferative Neoplasm","volume":"56","author":"N Imoto","year":"2017","journal-title":"Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1164\/ajrccm.149.3.8118651","article-title":"Secondary alveolar proteinosis is a reversible cause of respiratory failure in\n                    leukemic patients","volume":"149","author":"C Cordonnier","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00004424-198311000-00002","article-title":"Chest radiographic-pathologic correlation in adult leukemia patients","volume":"18","author":"C W Maile","year":"1983","journal-title":"Invest Radiol"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s003300101013","article-title":"CT findings of leukemic pulmonary infiltration with pathologic\n                    correlation","volume":"12","author":"N Tanaka","year":"2002","journal-title":"Eur Radiol"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/1097-0142(19870815)60:4<827::AID-CNCR2820600419>3.0.CO;2-A","article-title":"An autopsy study of 1206 acute and chronic leukemias (1958 to 1982)","volume":"60","author":"M Barcos","year":"1987","journal-title":"Cancer"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000225262","article-title":"An autopsy study of the metastatic patterns of human leukemias","volume":"35","author":"E Viadana","year":"1978","journal-title":"Oncology"},{"key":"ref14","first-page":"598","article-title":"The pulmonary manifestations and complications of leukemia","volume":"89","author":"E C Klatte","year":"1963","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jpeds.2020.04.003","article-title":"Evaluation of Chest Radiographs of Children with Newly Diagnosed Acute\n                    Lymphoblastic Leukemia","volume":"223","author":"W T Smith","year":"2020","journal-title":"J Pediatr"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1067\/j.cpradiol.2019.09.007","article-title":"Imaging Features of Pulmonary Leukemic Infiltration With Comparison of Lymphoid\n                    and Myeloid Leukemias","volume":"50","author":"B Gosangi","year":"2021","journal-title":"Curr Probl Diagn Radiol"},{"issue":"02","key":"ref17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2214\/ajr.174.2.1740517","article-title":"Pulmonary leukemic infiltrates: high-resolution CT findings in 10 patients","volume":"174","author":"L E Heyneman","year":"2000","journal-title":"AJR Am J Roentgenol"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2214\/ajr.182.3.1820761","article-title":"Thoracic CT findings of adult T-cell leukemia or lymphoma","volume":"182","author":"F Okada","year":"2004","journal-title":"AJR Am J Roentgenol"},{"issue":"10","key":"ref19","first-page":"1097","article-title":"Bronchiolocentric pulmonary involvement due to chronic lymphocytic leukemia","volume":"85","author":"R L Trisolini","year":"2000","journal-title":"Haematologica"},{"issue":"129","key":"ref20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1183\/09059180.00008812","article-title":"Serious bronchopulmonary involvement due to chronic lymphocytic leukaemia","volume":"22","author":"D Carmier","year":"2013","journal-title":"Eur Respir Rev"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1046\/j.1365-2141.2003.04192.x","article-title":"Leukaemic pulmonary infiltrates in adult acute myeloid leukaemia: a\n                    high-resolution computerized tomography study","volume":"120","author":"L Potenza","year":"2003","journal-title":"Br J Haematol"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1148\/radiol.2323031059","article-title":"Organizing pneumonia: perilobular pattern at thin-section CT","volume":"232","author":"M Ujita","year":"2004","journal-title":"Radiology"},{"issue":"03","key":"ref23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0037-198X(80)90049-8","article-title":"The intrathoracic manifestations of the malignant lymphomas and the\n                    leukemias","volume":"15","author":"N Blank","year":"1980","journal-title":"Semin Roentgenol"}],"container-title":["Klinische 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