{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:43:32Z","timestamp":1776210212664,"version":"3.50.1"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Amyloidosen sind eine heterogene Krankheitsgruppe, die sich durch die fibrill\u00e4re\nAblagerung von Peptiden und Proteinen in einer \u03b2-Faltblattstruktur\nmanifestieren. In Deutschland z\u00e4hlen die AL- und ATTR-Amyloidose zu den am\nh\u00e4ufigsten auftretenden systemischen Formen. Die ATTR-Amyloidose kennzeichnet\nder Befall des ligament\u00e4ren und tenosynovialen Gewebes bevor es zu einer\nHerzbeteiligung kommt, die wiederum lebensbegrenzed sein kann. Dies f\u00fchrt zu\neiner signifikant erh\u00f6hten klinischen Relevanz der Diagnostik von ATTR-Amyloid\nin Resektaten von hand- und plastisch-chirurgischen Eingriffen. Zu den\nErkrankungen, die in diesem Kontext als relevant erachtet werden, z\u00e4hlen das\nKarpaltunnelsyndrom, der schnellende Finger, die spontane Bizepssehnenruptur\nsowie die Spinalkanalstenose. Die Pr\u00e4valenz des ATTR-Amyloids nimmt mit dem\nAlter zu und erreicht in der neunten Lebensdekade nahezu 50%. Die w\u00e4hrend des\noperativen Eingriffs gewonnenen Gewebeproben sollten in Formalin fixiert werden.\nDer Nachweis von Amyloid wird in der Regel durch die Kongorot-F\u00e4rbung und unter\nEinsatz der Polarisationsmikroskopie erbracht. Die Sensitivit\u00e4t des Nachweises\nh\u00e4ngt von der Menge des gewonnenen Gewebes sowie dem jeweiligen\nKrankheitsstadium ab. Dabei ist zu ber\u00fccksichtigen, dass jede Gewebeart und\n-probe das Risiko eines Stichprobenfehlers aufweist. Nach dem Nachweis von\nAmyloid ist eine Klassifizierung des Amyloids erforderlich, da Amyloidosen\nbehandelbar geworden sind und die Therapie in Abh\u00e4ngigkeit vom Amyloidose-Typ\nerfolgt.<\/jats:p>","DOI":"10.1055\/a-2739-3771","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:44:31Z","timestamp":1764290671000},"page":"111-118","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostik der Amyloidose im Rahmen der Fr\u00fcherkennung bei hand- und\nplastisch-chirurgischen Patienten \u2013 welches Gewebe sollte wie untersucht\nwerden?"],"prefix":"10.1055","volume":"58","author":[{"given":"Christoph","family":"R\u00f6cken","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pathologie, Christian-Albrechts-Universit\u00e4t zu Kiel,\nMedizinische Fakult\u00e4t, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1056\/NEJMra023144","article-title":"Molecular mechanisms of amyloidosis","volume":"349","author":"G Merlini","year":"2003","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/13506129.2024.2405948","article-title":"Amyloid nomenclature 2024: update, novel proteins, and recommendations by the\nInternational Society of Amyloidosis (ISA) Nomenclature Committee","volume":"31","author":"J N Buxbaum","year":"2024","journal-title":"Amyloid"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1080\/13506129.2021.1994386","article-title":"Tissue biopsy for the diagnosis of amyloidosis: experience from some\ncentres","volume":"29","author":"M D 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Baranda","year":"2022","journal-title":"Amyloid"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jacc.2016.04.035","article-title":"Cardiac amyloid load: a prognostic and predictive biomarker in patients with\nlight-chain amyloidosis","volume":"68","author":"A V Kristen","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"625","DOI":"10.3109\/07853890.2015.1068949","article-title":"Evolving landscape in the management of transthyretin amyloidosis","volume":"47","author":"P N Hawkins","year":"2015","journal-title":"Ann Med"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1161\/CIRCULATIONAHA.118.038169","article-title":"Natural history, quality of life, and outcome in cardiac transthyretin\namyloidosis","volume":"140","author":"T 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Chirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2739-3771.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:45:02Z","timestamp":1776206702000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2739-3771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":38,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,4,14]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2739-3771","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0722-1819","1439-3980"],"issn-type":[{"value":"0722-1819","type":"print"},{"value":"1439-3980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]}}}