{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T23:44:41Z","timestamp":1765323881862,"version":"3.46.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study retrospectively evaluates the risk of chronic kidney disease (CKD)\n                        progression in patients with type 2 diabetes and mild-to-moderate reduction\n                        in the estimated glomerular filtration rate (eGFR).<\/jats:p>\n                  <jats:p>Sixty-six patients with type 2 diabetes and an eGFR between 45 and 60\n                        mL\/min\/1.73 m\u00b2 were included, from April 1, 2014, to March 31, 2015, with an\n                        8-year follow-up ending on March 31, 2023. Baseline clinical parameters,\n                        including the body mass index, blood pressure, and biochemical markers, were\n                        recorded. The HbA1c and eGFR levels were measured annually. The eGFR slope\n                        (mL\/min\/1.73 m\u00b2\/year) was used to evaluate the CKD progression.<\/jats:p>\n                  <jats:p>Patients with a negative eGFR slope (n=40) exhibited significantly greater\n                        HbA1c fluctuations and a higher coefficient of variation (CV) compared with\n                        those with an eGFR decline (P=0.011 for both) and were also markedly older\n                        (P=0.049). Logistic regression analysis showed a significant association\n                        between each one standard deviation increase in the CV and eGFR decline\n                        (odds ratio, 1.99; P=0.041), whereas the HbA1c fluctuation showed a trend\n                        toward association.<\/jats:p>\n                  <jats:p>Greater variability in glycemic control is linked to an increased risk for\n                        CKD progression in type 2 diabetes with mild-to-moderate kidney\n                        dysfunction.<\/jats:p>","DOI":"10.1055\/a-2742-2979","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T23:39:48Z","timestamp":1765323588000},"page":"509-515","source":"Crossref","is-referenced-by-count":0,"title":["High Glycemic Variability as a Risk Factor for CKD Progression in\n                    Type 2 Diabetes with Mild-to-Moderate Kidney Dysfunction"],"prefix":"10.1055","volume":"133","author":[{"given":"Taro","family":"Saigusa","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolic Diseases, Department\n                    of Internal Medicine, Nihon University School of Medicine, Itabashi,\n                    Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolic Diseases, Department\n                    of Internal Medicine, Nihon University School of Medicine, Itabashi,\n                    Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Takubo","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolic Diseases, Department\n                    of Internal Medicine, Nihon University School of Medicine, Itabashi,\n                    Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minami","family":"Kosuda","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolic Diseases, Department\n                    of Internal Medicine, Nihon University School of Medicine, Itabashi,\n                    Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamamotoya","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolic Diseases, Department\n                    of Internal Medicine, Nihon University School of Medicine, Itabashi,\n                    Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-6660","authenticated-orcid":false,"given":"Hisamitsu","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Division of Diabetes and Metabolic Diseases, Department\n                    of Internal Medicine, Nihon University School of Medicine, Itabashi,\n                    Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10157-024-02497-4","article-title":"Essential points from evidence-based clinical practice guideline for chronic\n                    kidney disease 2023","volume":"28","author":"Japanese Society of Nephrology","year":"2024","journal-title":"Clin Exp Nephrol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1007\/s00125-018-4691-2","article-title":"Non-albuminuric renal impairment is a strong predictor of mortality in\n                    individuals with type 2 diabetes: The Renal Insufficiency And Cardiovascular\n                    Events (RIACE) Italian multicentre study","volume":"61","author":"G Penno","year":"2018","journal-title":"Diabetologia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"Kidney disease: Improving global outcomes (KDIGO) CKD work group. 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Open"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1007\/s00125-019-4948-4","article-title":"The relationship between eGFR slope and subsequent risk of vascular outcomes and\n                    all-cause mortality in type 2 diabetes: The ADVANCE-ON study","volume":"62","author":"M Oshima","year":"2019","journal-title":"Diabetologia"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4137\/BMI.S38440","article-title":"Significance of HbA1c test in diagnosis and prognosis of diabetic patients","volume":"11","author":"S I Sherwani","year":"2016","journal-title":"Biomark Insights"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cca.2014.03.001","article-title":"Glycated albumin; clinical usefulness","volume":"433","author":"M Koga","year":"2014","journal-title":"Clin Chim Acta"},{"key":"ref32","first-page":"100224","article-title":"Finding the clinical utility of 1,5-anhydroglucitol among primary care\n                    practitioners","volume":"20","author":"J Peabody","year":"2020","journal-title":"J Clin Transl Endocrinol"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2742-2979.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T23:39:52Z","timestamp":1765323592000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2742-2979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,12,9]]},"published-print":{"date-parts":[[2025,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2742-2979","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}