{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:01:44Z","timestamp":1770505304803,"version":"3.49.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alveolar echinococcosis (AE) is a rare, potentially fatal zoonosis with highly heterogeneous morphology. This study compares AE lesions in B-scan ultrasound, categorized according to the Echinococcus multilocularis Ulm Classification \u2013 Ultrasound (EMUC-US), with the maximum standardized uptake value (SUVmax) in 18F-Fluorodeoxyglucose Positron-Emission-Tomography (18F-FDG-PET\/CT). 18F-FDG-PET\/CT is the gold standard for evaluating disease activity, with SUVmax as the key parameter indirectly reflecting AE lesion activity.<\/jats:p>\n                  <jats:p>Retrospective analysis of data from the German National Echinococcosis Database. A total of 121 patients with 18F-FDG-PET\/CT and B-scan ultrasound (US) between 2018\u20132019 were included. Based on EMUC-US, AE liver lesions were compared with the corresponding SUVmax in PET\/CT. Additionally, SUV ratios (SUVTLR=tumor SUVmax\/liver SUVmean) were calculated.<\/jats:p>\n                  <jats:p>The mean SUVmax, regardless of the EMUC-US subtype, was 6.0 \u00b1 3.3 (range: 2.4\u201318.0). SUVmax comparison between subtypes shows significant differences (p&lt;0.001). The highest SUVmax and SUVTLR were measured for the pseudocystic pattern with a mean of 9.2 \u00b1 3.5 (range: 4.1\u201318.0). In contrast, the metastasis-like pattern yielded 3.7 \u00b1 0.9 (range: 2.4\u20135.8) and the lowest SUVTLR. An SUVmax of 6.1 \u00b1 3.3 (range: 2.6\u201316.8) was measured for the hailstorm pattern and 5.8 \u00b1 2.2 (range: 3.6\u201310.4) for the hemangioma-like pattern.<\/jats:p>\n                  <jats:p>The results show significant differences between specific US patterns and the corresponding SUVmax. Lesions with very high or low SUV correlate with characteristic morphological patterns. Hence, in clinical practice B-scan can be a valuable bedside tool for assessing certain lesions. For evaluating inflammatory activity, 18F-FDG-PET\/CT remains the method of choice.<\/jats:p>","DOI":"10.1055\/a-2744-4139","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:14:51Z","timestamp":1764634491000},"page":"4-12","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis of hepatic alveolar echinococcosis:18F-FDG-PET activity compared to the Echinococcus multilocularis Ulm Ultrasound Classification"],"prefix":"10.1055","volume":"65","author":[{"given":"Wolfgang","family":"Kratzer","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibylle","family":"Steinkellner","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis","family":"Skotnik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Infectious Diseases, Ulm University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Gruener","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Division of Infectious Diseases, Ulm University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Eberhardt","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ulm University Hospital, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/bs.apar.2016.09.006","article-title":"The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease","volume":"96","author":"P Kern","year":"2017","journal-title":"Adv Parasitol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s15010-019-01325-2","article-title":"Worldwide literature on epidemiology of human alveolar echinococcosis: a systematic review of research published in the twenty-first century","volume":"47","author":"S Baumann","year":"2019","journal-title":"Infection"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2015-000036","article-title":"Pitfalls in diagnosis and treatment of alveolar echinococcosis: a sentinel case series","volume":"2","author":"M 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Comparison of parametric contrast enhanced ultrasound (SonoVue) with quantified 18F-FDG-PET-CT","volume":"54","author":"TE Kaltenbach","year":"2015","journal-title":"Nuklearmedizin"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.2967\/jnumed.119.233940","article-title":"PET\/MRI Versus PET\/CT for Whole-Body Staging: Results from a Single-Center Observational Study on 1,003 Sequential Examinations","volume":"61","author":"O Martin","year":"2020","journal-title":"J Nucl Med"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1111\/tmi.13228","article-title":"FDG-PET\/MRI imaging for the management of alveolar echinococcosis: initial clinical experience at a reference centre in Austria","volume":"24","author":"F L\u00f6tsch","year":"2019","journal-title":"Trop Med Int Health"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3390\/pathogens11030348","article-title":"18F-FDG-PET\/MR in Alveolar Echinococcosis: Multiparametric Imaging in a Real-World Setting","volume":"11","author":"N Eberhardt","year":"2022","journal-title":"Pathogens"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3390\/pathogens11050557","article-title":"Initial Risk Assessment in Patients with Alveolar Echinococcosis-Results from a Retrospective Cohort Study","volume":"11","author":"L Peters","year":"2022","journal-title":"Pathogens"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3390\/pathogens9080634","article-title":"Combining Computed Tomography and Histology Leads to an Evolutionary Concept of Hepatic Alveolar Echinococcosis","volume":"9","author":"J Grimm","year":"2020","journal-title":"Pathogens"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1007\/s40336-021-00445-w","article-title":"Italian consensus document on the use of [18F] FDG PET\/CT in infectious and inflammatory diseases","volume":"48","author":"M Casali","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00259-012-2344-0","article-title":"EANM\/SNMMI guideline for 18F-FDG use in inflammation and infection","volume":"40","author":"F Jamar","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["Nuklearmedizin - NuclearMedicine"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2744-4139.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:30:23Z","timestamp":1770420623000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2744-4139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,1]]},"references-count":40,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,2,6]]},"published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2744-4139","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,1]]}}}