{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T22:44:04Z","timestamp":1776984244784,"version":"3.51.4"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Kaempferol, a flavonol found in various edible and medicinal plants, possesses antioxidant, anti-inflammatory, and cardioprotective properties. The vasorelaxant effects of kaempferol were assessed using isolated coronary artery rings pre-contracted with potassium chloride (30\u2009mM). Kaempferol induced a concentration-dependent relaxation in both endothelium-intact and endothelium-denuded coronary artery rings pre-contracted with potassium chloride (30\u2009mM), indicating that its vasorelaxant effect is primarily endothelium-independent. Inhibition of nitric oxide synthase (NOS) with L-NAME (100\u2009\u00b5M) and cyclooxygenase (COX) with indomethacin (10\u2009\u00b5M) did not significantly alter the relaxation response, suggesting that nitric oxide (NO) and prostaglandins play a minimal role. The BKCa channel blocker TEA (1\u2009mM), ATP-sensitive potassium (KATP) channel blocker glibenclamide (10\u2009\u00b5M), and inward-rectifier potassium (KIR) channel blocker BaCl2\n          (30\u2009\u00b5M) did not significantly affect kaempferol-induced relaxation. However, inhibition with the voltage-gated potassium (KV) channel blocker 4-aminopyridine (3\u2009mM) significantly reduced the relaxation response, indicating the involvement of KV channels. Furthermore, molecular analysis using RT-PCR confirmed the presence of the KV\u20092.1 (KCNB1) gene in sheep coronary arteries, suggesting its role in kaempferol-mediated vasorelaxation. These findings suggest that kaempferol promotes vasorelaxation through an endothelium-independent mechanism, with partial involvement of the KV\u20092.1 channel. This study supports kaempferol\u02bcs therapeutic potential in cardiovascular disease, recommending its dietary inclusion as a strategy to lower the risk of cardiovascular diseases.<\/jats:p>","DOI":"10.1055\/a-2744-6009","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:58:44Z","timestamp":1762905524000},"page":"574-583","source":"Crossref","is-referenced-by-count":0,"title":["Kaempferol Promotes Vasorelaxation via KV\u20092.1 Channel Modulation in the Coronary Arteries of Sheep"],"prefix":"10.1055","volume":"92","author":[{"given":"Ajay","family":"Bhati","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratishtha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirti","family":"Purva","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Kant","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivangi","family":"Gaur","sequence":"additional","affiliation":[{"name":"MBBS student, Rama Medical College, Hapur, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit Kumar","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biochemistry, College of Veterinary and Animal Science, Bikaner, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/138955711795305335","article-title":"A review on the dietary flavonoid kaempferol","volume":"11","author":"J M Calder\u00f3n-Monta\u00f1o","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9966750","DOI":"10.1155\/2022\/9966750","article-title":"Flavonols and flavones as potential anti-inflammatory, antioxidant, and antibacterial compounds","volume":"2022","author":"M DSS 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