{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T13:52:19Z","timestamp":1769781139836,"version":"3.49.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"02","funder":[{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"crossref","award":["K15040"],"award-info":[{"award-number":["K15040"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009338","name":"National Marine Biodiversity Institute of Korea","doi-asserted-by":"crossref","award":["MABIK2025M00500"],"award-info":[{"award-number":["MABIK2025M00500"]}],"id":[{"id":"10.13039\/501100009338","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetic retinopathy (DR) is a leading cause of blindness, and its pathogenesis is strongly linked to the activation of aldose reductase (AR) under hyperglycemic conditions. Developing effective AR inhibitors (ARIs), particularly from natural sources, remains a critical therapeutic goal. This study investigated the AR inhibitory potential of an 80% ethanol extract from the leaves of Aster tataricus. Using UPLC-Q-Orbitrap-MS, we identified 11 major compounds, with caffeoylquinic acids (CQAs) being predominant. In vitro assays on rat lens aldose reductase (RLAR) revealed that di-caffeoylquinic acids (di-CQAs), particularly 3,5-di-O-caffeoylquinic acid (3,5-DCQA; IC50\u2009=\u20090.31\u2009\u00b5M), were potent noncompetitive inhibitors. Molecular docking simulations provided insights into their binding modes within the enzyme. The therapeutic relevance of these findings was confirmed in vivo using a larval zebrafish model of hyperglycemia, where both the\n          A.\u00a0tataricus extract and its constituent CQAs significantly suppressed hyaloid-retinal vessel dilation without inducing toxicity. Quantitative HPLC analysis confirmed that 3,5-DCQA was the most abundant di-CQA in the extract. These findings establish the CQA constituents of A.\u00a0tataricus leaves as promising natural product leads for developing therapeutics to manage early-stage diabetic retinopathy.<\/jats:p>","DOI":"10.1055\/a-2744-6263","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T23:58:44Z","timestamp":1762905524000},"page":"148-159","source":"Crossref","is-referenced-by-count":0,"title":["Caffeoylquinic Acids from Aster tataricus Leaves Inhibit Aldose Reductase and Attenuate Hyaloid-Retinal Vasodilation in a Zebrafish Model of Hyperglycemia"],"prefix":"10.1055","volume":"92","author":[{"given":"Ik Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biomaterial Research, National Marine Biodiversity Institute of Korea, Seocheon-gun, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sook","family":"Kim","sequence":"additional","affiliation":[{"name":"KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global prevalence of diabetic retinopathy and projection of burden through 2045: Systematic review and meta-analysis","volume":"128","author":"Z L Teo","year":"2021","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3390\/biomedicines12040747","article-title":"Aldose reductase as a key target in the prevention and treatment of diabetic retinopathy: A comprehensive 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