{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:28:32Z","timestamp":1791440912767,"version":"4.3.3"},"reference-count":145,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"National Institute on Aging of the National Institutes of Health","award":["K23AG093166"],"award-info":[{"award-number":["K23AG093166"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As the U.S. population ages, Alzheimer's disease and related dementias (ADRD) cases are increasing, resulting in long wait times for specialist care. We review state-of-the-art artificial intelligence (AI) applications in ADRD care, from streamlining clinical diagnosis to pioneering novel digital biomarkers. Near-term AI applications include neuroimaging interpretation, conversational agents for patient interviews, and digital cognitive assessments. Large language models show promise as collaborative partners, helping clinicians interpret complex data while supporting patients and caregivers. Emerging digital biomarkers\u2014speech analysis, passive monitoring through wearable devices, electronic health record analysis, and multiomics\u2014offer potential for continuous monitoring to detect cognitive decline years before traditional assessments. Despite the acceleration of AI innovation, most of these systems are inaccessible in clinical practice. Implementation bottlenecks include limited external validation, technical challenges, model biases, infrastructure, and regulatory requirements. This review aims to help neurologists navigate this rapidly evolving AI landscape and prepare for implementation in ADRD care.<\/jats:p>","DOI":"10.1055\/a-2744-9871","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:11:30Z","timestamp":1764375090000},"page":"105-116","source":"Crossref","is-referenced-by-count":7,"title":["Review of Artificial Intelligence for Clinical Use in Alzheimer's Disease and Related Dementias"],"prefix":"10.1055","volume":"46","author":[{"given":"Andrew G.","family":"Breithaupt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine, Emory Goizueta Brain Health Institute, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Tang","sequence":"additional","affiliation":[{"name":"Bakar Computational Health Sciences Institute and School of Medicine, University of California, San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily W.","family":"Paolillo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merna","family":"Bibars","sequence":"additional","affiliation":[{"name":"Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C. B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University School of Medicine, Emory Goizueta Brain Health Institute, Atlanta, Georgia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan","family":"Saloner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine L.","family":"Possin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States"},{"name":"Department of Neurology, Global Brain Health Institute, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.","family":"Windon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanisha G.","family":"Hill-Jarrett","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States"},{"name":"Department of Neurology, Global Brain Health Institute, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Giorgio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of California, Berkeley, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas M.","family":"Rauschecker","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Center for Intelligent Imaging, University of California, San Francisco, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeokhyen","family":"Kwon","sequence":"additional","affiliation":[{"name":"Wallace H. 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J.","family":"Vonk","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Pinheiro-Chagas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"issue":"19","key":"ref1","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010-2050) estimated using the 2010 census","volume":"80","author":"L E 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