{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:58:44Z","timestamp":1790294324303,"version":"4.1.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Postoperative atrial fibrillation (POAF) is a frequent complication after coronary artery bypass grafting (CABG) and is linked to increased short- and long-term stroke risk. This study evaluated the prognostic value of the left atrial diameter index (LADI) for predicting cerebrovascular events (CVE) in patients undergoing isolated CABG who developed POAF, had no prior atrial fibrillation (AF), and were discharged in sinus rhythm.<\/jats:p>\n                  <jats:p>Among 2,094 patients undergoing isolated CABG between June 2015 and June 2022, 392 consecutive patients with POAF and discharge in sinus rhythm met inclusion criteria. LADI was calculated preoperatively, and an optimal cutoff (21.2\u2009mm\/m2) was determined via receiver operating characteristic curve and Youden index. Patients were classified as low (\u226421.2\u2009mm\/m2) or high (&gt;21.2\u2009mm\/m2) LADI. The association between LADI and CVE was assessed over a mean follow-up of 42.4\u2009\u00b1\u200920.0 months using Cox proportional hazards modeling.<\/jats:p>\n                  <jats:p>Thirty patients (7.7%) experienced a CVE, including eight in-hospital cases (2.0%). CVE incidence was higher in the high LADI group compared with the low LADI group (19.8 vs. 2.8%). Multivariable analysis identified older age, hypertension, congestive heart failure, and high LADI as independent CVE predictors. Kaplan\u2013Meier analysis confirmed significantly higher CVE rates in the high LADI group (log-rank, p\u2009&lt;\u20090.001).<\/jats:p>\n                  <jats:p>In patients developing POAF after isolated CABG, LADI is a simple, easily obtainable parameter that independently predicts long-term CVE risk and may aid in postoperative risk stratification.<\/jats:p>","DOI":"10.1055\/a-2747-7537","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T23:49:22Z","timestamp":1763164162000},"source":"Crossref","is-referenced-by-count":1,"title":["Left Atrial Diameter Index Predicts Cerebrovascular Events after Postoperative Atrial Fibrillation following Coronary Artery Bypass Grafting"],"prefix":"10.1055","author":[{"given":"Arda Can","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"TC Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 \u0130skenderun Devlet Hastanesi, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali R\u0131za","family":"Demir","sequence":"additional","affiliation":[{"name":"\u0130stanbul Mehmet Akif Ersoy G\u00f6\u011f\u00fcs Kalp Ve Damar Cerrahisi E\u011fitim Ve Ara\u015ft\u0131rma Hastanesi, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alk\u0131m Ate\u015fli","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Ministry of Health Kirikhan State Hospital, Antakya, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batuhan","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Hatay E\u011fitim ve Ara\u015ft\u0131rma Hastanesi, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Kemal","family":"Kalkan","sequence":"additional","affiliation":[{"name":"Ministry of Health Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"G Hindricks","year":"2021","journal-title":"Eur Heart J"},{"issue":"36","key":"ref2","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"I C Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ijcard.2016.06.249","article-title":"Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium","volume":"220","author":"J AB Zaman","year":"2016","journal-title":"Int J Cardiol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jacc.2020.10.050","article-title":"Preventing atrial fibrillation after cardiac surgery: what matters most","volume":"77","author":"J H Alexander","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055\/a-2474-2827","article-title":"A new predisposing factor for postoperative atrial fibrillation: tube insertion site","author":"Z Apayd\u0131n","year":"2024","journal-title":"Thorac Cardiovasc Surg"},{"issue":"14","key":"ref6","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1001\/jama.291.14.1720","article-title":"A multicenter risk index for atrial fibrillation after cardiac surgery","volume":"291","author":"J P Mathew","year":"2004","journal-title":"JAMA"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jtcvs.2010.03.011","article-title":"The persistent problem of new-onset postoperative atrial fibrillation: a single-institution experience over two decades","volume":"141","author":"J Shen","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1161\/STROKEAHA.118.023921","article-title":"Perioperative\/postoperative atrial fibrillation and risk of subsequent stroke and\/or mortality","volume":"50","author":"M H Lin","year":"2019","journal-title":"Stroke"},{"issue":"02","key":"ref9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.athoracsur.2020.05.104","article-title":"Postoperative atrial fibrillation after cardiac surgery: a systematic review and meta-analysis","volume":"111","author":"R Eikelboom","year":"2021","journal-title":"Ann Thorac Surg"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.5761\/atcs.oa.19-00314","article-title":"Gender differences in predictors and long-term mortality of new-onset postoperative atrial fibrillation following isolated aortic valve replacement surgery","volume":"26","author":"M Frag\u00e3o-Marques","year":"2020","journal-title":"Ann Thorac Cardiovasc Surg"},{"issue":"05","key":"ref11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jacc.2003.11.023","article-title":"Postoperative atrial fibrillation and mortality after coronary artery bypass surgery","volume":"43","author":"R P Villareal","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/icvts\/ivx348","article-title":"Incidence of postoperative atrial fibrillation recurrence in patients discharged in sinus rhythm after cardiac surgery: a systematic review and meta-analysis","volume":"26","author":"N Lowres","year":"2018","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"08","key":"ref13","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jacc.2007.10.043","article-title":"Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery","volume":"51","author":"N Echahidi","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/0735-1097(94)00560-D","article-title":"Transesophageal echocardiographically facilitated early cardioversion from atrial fibrillation using short-term anticoagulation: final results of a prospective 4.5-year study","volume":"25","author":"W J Manning","year":"1995","journal-title":"J Am Coll Cardiol"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.09.023","article-title":"The role of left atrial volume index in patients with a first-ever acute ischemic stroke","volume":"26","author":"M Biteker","year":"2017","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"31042","DOI":"10.1038\/srep31042","article-title":"Left atrial enlargement is an independent predictor of stroke and systemic embolism in patients with non-valvular atrial fibrillation","volume":"6","author":"Y Hamatani","year":"2016","journal-title":"Sci Rep"},{"issue":"08","key":"ref17","doi-asserted-by":"crossref","first-page":"e006402","DOI":"10.1161\/JAHA.117.006402","article-title":"Left atrial size and long-term risk of recurrent stroke after acute ischemic stroke in patients with nonvalvular atrial fibrillation","volume":"6","author":"T Ogata","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"23","key":"ref18","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1161\/CIR.0000000000000040","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society","volume":"130","author":"C T January","year":"2014","journal-title":"Circulation"},{"issue":"17","key":"ref19","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"R D Mosteller","year":"1987","journal-title":"N Engl J Med"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jacc.2003.12.011","article-title":"Postoperative atrial fibrillation and mortality: do the risks merit changes in clinical practice?","volume":"43","author":"D Levy","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0022-5223(97)70142-9","article-title":"Outcome of atrial fibrillation after mitral valve repair","volume":"114","author":"J F Obadia","year":"1997","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1445-5994.1985.tb02726.x","article-title":"Atrial tachyarrhythmias after cardiac surgery: results of disopyramide therapy","volume":"15","author":"T P Gavaghan","year":"1985","journal-title":"Aust N Z J Med"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"e007558","DOI":"10.1161\/JAHA.117.007558","article-title":"New-onset atrial fibrillation after coronary artery bypass graft and long-term risk of stroke: a meta-analysis","volume":"6","author":"M R Megens","year":"2017","journal-title":"J Am Heart Assoc"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.athoracsur.2014.03.039","article-title":"Postoperative atrial fibrillation significantly increases mortality, hospital readmission, and hospital costs","volume":"98","author":"D J LaPar","year":"2014","journal-title":"Ann Thorac Surg"},{"issue":"06","key":"ref25","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/ejcts\/ezu551","article-title":"New-onset atrial fibrillation following coronary bypass surgery predicts long-term mortality: a systematic review and meta-analysis","volume":"48","author":"K Phan","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"issue":"01","key":"ref26","first-page":"2","article-title":"Pharmacological and nonpharmacological prevention of atrial fibrillation after coronary artery bypass surgery","volume":"7","author":"M Haghjoo","year":"2012","journal-title":"J Tehran Univ Heart Cent"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5761\/atcs.oa.12.01950","article-title":"Does warfarin help prevent ischemic stroke in patients presenting with post coronary bypass paroxysmal atrial fibrillation?","volume":"19","author":"M Hata","year":"2013","journal-title":"Ann Thorac Cardiovasc Surg"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.athoracsur.2006.03.037","article-title":"Relationship of atrial fibrillation and stroke after coronary artery bypass graft surgery: when is anticoagulation indicated?","volume":"82","author":"A Kollar","year":"2006","journal-title":"Ann Thorac Surg"},{"issue":"02","key":"ref29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.athoracsur.2011.04.066","article-title":"Routine anticoagulation is not indicated for postoperative general thoracic surgical patients with new-onset atrial fibrillation","volume":"92","author":"Z Makhija","year":"2011","journal-title":"Ann Thorac Surg"},{"issue":"13","key":"ref30","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.jacc.2009.10.058","article-title":"New-onset atrial fibrillation predicts long-term mortality after coronary artery bypass graft","volume":"55","author":"M F El-Chami","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/pace.14095","article-title":"Attitudes toward anticoagulation for postoperative atrial fibrillation: a nationwide survey of VA providers","volume":"43","author":"F S Riad","year":"2020","journal-title":"Pacing Clin Electrophysiol"},{"issue":"14","key":"ref32","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1161\/CIRCULATIONAHA.120.046940","article-title":"Postoperative atrial fibrillation and long-term risk of stroke after isolated coronary artery bypass graft surgery","volume":"142","author":"U Benedetto","year":"2020","journal-title":"Circulation"},{"issue":"03","key":"ref33","doi-asserted-by":"crossref","first-page":"105591","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105591","article-title":"Determination of cerebrovascular accident predictors in patients with new-onset atrial fibrillation after coronary artery bypass graft surgery","volume":"30","author":"A R Demir","year":"2021","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/europace\/eur272","article-title":"Possible refinement of clinical thromboembolism assessment in patients with atrial fibrillation using echocardiographic parameters","volume":"14","author":"R Provid\u00eancia","year":"2012","journal-title":"Europace"},{"issue":"02","key":"ref35","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/01.CIR.89.2.724","article-title":"Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study","volume":"89","author":"S M Vaziri","year":"1994","journal-title":"Circulation"},{"issue":"02","key":"ref36","first-page":"206","article-title":"Left atrial size and risk of stroke in patients in sinus rhythm. A systematic review","volume":"116","author":"T F Overvad","year":"2016","journal-title":"Thromb Haemost"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fneur.2020.00026","article-title":"Left atrial enlargement and the risk of stroke: a meta-analysis of prospective cohort studies","volume":"11","author":"Y Xu","year":"2020","journal-title":"Front Neurol"},{"issue":"07","key":"ref38","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.3390\/jcm11071838","article-title":"Left atrial diameter in the prediction of thromboembolic event and death in atrial fibrillation","volume":"11","author":"R Krittayaphong","year":"2022","journal-title":"J Clin Med"},{"issue":"02","key":"ref39","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1161\/01.HYP.0000254322.96189.85","article-title":"Left atrial size and risk of major cardiovascular events during antihypertensive treatment: losartan intervention for endpoint reduction in hypertension trial","volume":"49","author":"E Gerdts","year":"2007","journal-title":"Hypertension"},{"issue":"01","key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2014.10.003","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"28","author":"R M Lang","year":"2015","journal-title":"J Am Soc Echocardiogr"}],"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2747-7537.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:03:58Z","timestamp":1790291038000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2747-7537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":40,"URL":"https:\/\/doi.org\/10.1055\/a-2747-7537","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,11,14]]},"published":{"date-parts":[[2025,11,14]]}}}