{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:30:32Z","timestamp":1781008232796,"version":"3.54.1"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100009553","name":"Czech Health Research Council","doi-asserted-by":"crossref","award":["NU21J-02\u201300021"],"award-info":[{"award-number":["NU21J-02\u201300021"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","award":["PRIMUS\/25\/MED\/001"],"award-info":[{"award-number":["PRIMUS\/25\/MED\/001"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"crossref","award":["SVV 260 549"],"award-info":[{"award-number":["SVV 260 549"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MH CZ - DRO","award":["UHHK, 00179906"],"award-info":[{"award-number":["UHHK, 00179906"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Platelet\u2013monocyte aggregates (PMA) are modern biomarkers for the early onset of cardiovascular diseases (CVD). PMA occur in the presence of activated platelets (AP), whose incidence is higher in patients with metabolic diseases. These patients frequently benefit from anticoagulant therapy, particularly in advanced disease stages. However, the impact of these drugs on PMA occurrence is unknown.<\/jats:p>\n                  <jats:p>Blood samples from healthy volunteers, patients with type 1 diabetes mellitus (DMT1), type 2 diabetes mellitus (DMT2), dyslipidemia (hypercholesterolemia), and severe forms of familial hypercholesterolemia (FH) were analyzed by flow cytometry to detect both AP and PMA. Subsequently, blood samples were treated with four direct anticoagulants (rivaroxaban, apixaban, dabigatran, or argatroban, all at a final concentration of 1 \u00b5M), and PMA were again detected. Anthropological and biochemical parameters were recorded and correlated with AP and PMA.<\/jats:p>\n                  <jats:p>AP levels were higher solely in DMT2 patients, but PMA occurrence was significantly increased in all patient groups in comparison to that of generally healthy donors, except for FH patients. No sex-related differences were observed, but an increasing trend in AP and PMA incidence was observed with increasing age and BMI. Significant correlations of AP and PMA with anthropological and biochemical parameters were found solely in some groups of patients or in some anticoagulant-treated samples. Only argatroban and apixaban-treated samples significantly decreased PMA occurrence, and this was observed solely in the dyslipidemia patient group.<\/jats:p>\n                  <jats:p>These findings suggest a potential positive outcome of anticoagulant treatment for metabolic disease patients and confirm PMA as a sensitive marker in patients with metabolic diseases.<\/jats:p>","DOI":"10.1055\/a-2747-8963","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:03Z","timestamp":1764979203000},"source":"Crossref","is-referenced-by-count":1,"title":["Occurrence of Platelet\u2013Monocyte Aggregates in Patients with Metabolic Disorders and Effect of Direct Anticoagulants"],"prefix":"10.1055","author":[{"given":"Catherine","family":"Gunaseelan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Lomozov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Hrub\u0161a","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark\u00e9ta","family":"Paclikov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine\u2013Metabolic Care and Gerontology, University Hospital and Faculty of Medicine in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Sko\u0159epa","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine\u2013Metabolic Care and Gerontology, University Hospital and Faculty of Medicine in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"},{"name":"Department of Military Internal Medicine and Military Hygiene, Military Faculty of Medicine, University of Defence, Hradec Kralove, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"Matou\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"The Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kr\u00e1lov\u00e9, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Turonov\u00e1","sequence":"additional","affiliation":[{"name":"The Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kr\u00e1lov\u00e9, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka Kujovsk\u00e1","family":"Krcmov\u00e1","sequence":"additional","affiliation":[{"name":"The Department of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kr\u00e1lov\u00e9, Hradec Kr\u00e1lov\u00e9, Czechia"},{"name":"Department Analytical Chemistry, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Bl\u00e1ha","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine\u2013Metabolic Care and Gerontology, University Hospital and Faculty of Medicine in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edr","family":"Blaha","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine\u2013Metabolic Care and Gerontology, University Hospital and Faculty of Medicine in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-6900","authenticated-orcid":false,"given":"P\u0159emysl","family":"Mlad\u011bnka","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3604-7981","authenticated-orcid":false,"given":"Alejandro","family":"Carazo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Hradec Kr\u00e1lov\u00e9, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"issue":"09","key":"ref2","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.4049\/jimmunol.1900899","article-title":"Platelets in inflammation and resolution","volume":"203","author":"A Margraf","year":"2019","journal-title":"J Immunol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI122955","article-title":"Functional significance of the platelet immune receptors GPVI and CLEC-2","volume":"129","author":"J Rayes","year":"2019","journal-title":"J Clin Invest"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1080\/09537104.2018.1430357","article-title":"Platelets in wound healing and regenerative medicine","volume":"29","author":"J Etulain","year":"2018","journal-title":"Platelets"},{"issue":"04","key":"ref5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nri2956","article-title":"Platelets and the immune continuum","volume":"11","author":"J W Semple","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"960398","DOI":"10.3389\/fcvm.2023.960398","article-title":"Platelet-monocyte aggregates: molecular mediators of thromboinflammation","volume":"10","author":"C C Rolling","year":"2023","journal-title":"Front Cardiovasc Med"},{"issue":"13","key":"ref7","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/hc3801.095588","article-title":"Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction","volume":"104","author":"A D Michelson","year":"2001","journal-title":"Circulation"},{"issue":"20","key":"ref8","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.2174\/092986708785132852","article-title":"Platelet-monocyte interactions\u2014a dangerous liaison linking thrombosis, inflammation and atherosclerosis","volume":"15","author":"P Seizer","year":"2008","journal-title":"Curr Med Chem"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1043-2760(01)00391-5","article-title":"Diabetes mellitus and diabetes-associated vascular disease","volume":"12","author":"D Kirpichnikov","year":"2001","journal-title":"Trends Endocrinol Metab"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3132\/dvdr.2005.001","article-title":"Pathobiology and cell interactions of platelets in diabetes","volume":"2","author":"B Stratmann","year":"2005","journal-title":"Diab Vasc Dis Res"},{"issue":"13","key":"ref11","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1161\/CIR.0000000000000034","article-title":"Type 1 diabetes mellitus and cardiovascular disease: a scientific statement from the American Heart Association and American Diabetes Association","volume":"130","author":"S D de Ferranti","year":"2014","journal-title":"Circulation"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"840797","DOI":"10.3389\/fgene.2022.840797","article-title":"Familial hypercholesterolemia prevalence among ethnicities\u2014systematic review and meta-analysis","volume":"13","author":"F Toft-Nielsen","year":"2022","journal-title":"Front Genet"},{"issue":"16","key":"ref13","doi-asserted-by":"crossref","first-page":"9146","DOI":"10.3390\/ijms23169146","article-title":"Importance of coagulation factors as critical components of premature cardiovascular disease in familial hypercholesterolemia","volume":"23","author":"U Ravnskov","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"09","key":"ref14","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1161\/01.CIR.96.9.2877","article-title":"Differential effects of anticoagulants on the activation of platelets ex vivo","volume":"96","author":"D J Schneider","year":"1997","journal-title":"Circulation"},{"issue":"08","key":"ref15","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.3390\/nu15081842","article-title":"The effect of 4-methylcatechol on platelets in familial hypercholesterolemic patients treated with lipid apheresis and\/or proprotein convertase subtilisin kexin 9 monoclonal antibodies","volume":"15","author":"L Kone\u010dn\u00fd","year":"2023","journal-title":"Nutrients"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"F Mach","year":"2020","journal-title":"Eur Heart J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.2337\/dc25-SINT","article-title":"Introduction and methodology: standards of care in diabetes-2025","volume":"48","author":"American Diabetes Association Professional Practice Committee","year":"2025","journal-title":"Diabetes Care"},{"issue":"05","key":"ref18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1055\/s-0042-1756703","article-title":"Sex-related differences in platelet aggregation: a literature review supplemented with local data from a group of generally healthy individuals","volume":"49","author":"A Carazo","year":"2023","journal-title":"Semin Thromb Hemost"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bbrc.2005.01.146","article-title":"Preferential binding of platelets to monocytes over neutrophils under flow","volume":"329","author":"K C Ahn","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosis.2018.12.029","article-title":"Circulating monocyte-platelet aggregates are a robust marker of platelet activity in cardiovascular disease","volume":"282","author":"N Allen","year":"2019","journal-title":"Atherosclerosis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ijcard.2019.04.009","article-title":"Monocyte-platelet aggregates affect local inflammation in patients with acute myocardial infarction","volume":"287","author":"H Kossmann","year":"2019","journal-title":"Int J Cardiol"},{"issue":"03","key":"ref22","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1055\/s-0038-1648888","article-title":"Polymorphonuclear leukocyte-platelet interaction: role of P-selectin in thromboxane B2 and leukotriene C4 cooperative synthesis","volume":"72","author":"N Maugeri","year":"1994","journal-title":"Thromb Haemost"},{"issue":"02","key":"ref23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1055\/s-2007-1000390","article-title":"The activated megakaryocyte-platelet-system in vascular disease: focus on diabetes","volume":"21","author":"D Tschoepe","year":"1995","journal-title":"Semin Thromb Hemost"},{"issue":"02","key":"ref24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3109\/09537109409005516","article-title":"Platelets and the lipoproteins: native, modified and platelet modified lipoproteins","volume":"5","author":"E Malle","year":"1994","journal-title":"Platelets"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4239\/wjd.v5.i4.444","article-title":"Type 2 diabetes and cardiovascular disease: have all risk factors the same strength?","volume":"5","author":"I Mart\u00edn-Tim\u00f3n","year":"2014","journal-title":"World J Diabetes"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1161\/CIRCRESAHA.115.306884","article-title":"Vascular complications of diabetes","volume":"118","author":"J A Beckman","year":"2016","journal-title":"Circ Res"},{"issue":"08","key":"ref27","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1007\/s11695-014-1278-y","article-title":"Bariatric surgery decreases monocyte-platelet aggregates in blood: a pilot study","volume":"24","author":"M Periasamy","year":"2014","journal-title":"Obes Surg"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.ATV.10.6.1119","article-title":"Hemostatic variables in homozygous familial hypercholesterolemia. Effect of regular plasma cholesterol removal by low density lipoprotein apheresis","volume":"10","author":"G Di Minno","year":"1990","journal-title":"Arteriosclerosis"},{"issue":"03","key":"ref29","first-page":"476","article-title":"Platelet hyperactivity after statin treatment discontinuation","volume":"90","author":"L Puccetti","year":"2003","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref30","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/ATVBAHA.120.314485","article-title":"Phosphoproteomic analysis of platelets in severe obesity uncovers platelet reactivity and signaling pathways alterations","volume":"41","author":"M N Barrachina","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"03","key":"ref31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2141.2006.06012.x","article-title":"High glucose levels enhance platelet activation: involvement of multiple mechanisms","volume":"133","author":"D Sudic","year":"2006","journal-title":"Br J Haematol"},{"issue":"03","key":"ref32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11892-007-0035-1","article-title":"Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation","volume":"7","author":"G Boden","year":"2007","journal-title":"Curr Diab Rep"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12933-025-02891-6","article-title":"Acetylsalicylic acid and vorapaxar are less active, while 4-methylcatechol is more active, in type 1 diabetic patients compared to healthy controls","volume":"24","author":"M Pacl\u00edkov\u00e1","year":"2025","journal-title":"Cardiovasc Diabetol"},{"issue":"02","key":"ref34","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1161\/01.ATV.0000199519.37089.a0","article-title":"Platelet inhibition by insulin is absent in type 2 diabetes mellitus","volume":"26","author":"I A Ferreira","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.clinbiochem.2005.09.005","article-title":"Do platelet apoptosis, activation, aggregation, lipid peroxidation and platelet-leukocyte aggregate formation occur simultaneously in hyperlipidemia?","volume":"38","author":"A Sener","year":"2005","journal-title":"Clin Biochem"},{"issue":"08","key":"ref36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/09537100600760814","article-title":"Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects","volume":"17","author":"V R Vaidyula","year":"2006","journal-title":"Platelets"},{"issue":"03","key":"ref37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.thromres.2011.04.018","article-title":"P-selectin ligation induces platelet activation and enhances microaggregate and thrombus formation","volume":"128","author":"J F Th\u00e9or\u00eat","year":"2011","journal-title":"Thromb Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1749-6632.2011.06320.x","article-title":"Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications","volume":"1243","author":"R Ramasamy","year":"2011","journal-title":"Ann N Y Acad Sci"},{"issue":"06","key":"ref39","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.thromres.2007.07.016","article-title":"Circulating platelet-leukocyte aggregates: a marker of microvascular injury in diabetic patients","volume":"121","author":"I Elalamy","year":"2008","journal-title":"Thromb Res"},{"issue":"06","key":"ref40","doi-asserted-by":"crossref","first-page":"344","DOI":"10.5551\/jat.12.344","article-title":"Platelet-monocyte aggregates are independently associated with occurrence of carotid plaques in type 2 diabetic patients","volume":"12","author":"T Shoji","year":"2005","journal-title":"J Atheroscler Thromb"},{"issue":"02","key":"ref41","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.atherosclerosis.2004.05.008","article-title":"Increased CD40 ligand and platelet-monocyte aggregates in patients with type 1 diabetes mellitus","volume":"176","author":"S A Harding","year":"2004","journal-title":"Atherosclerosis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12933-015-0244-x","article-title":"High-risk type-2 diabetes mellitus patients, without prior ischemic events, have normal blood platelet functionality profiles: a cross-sectional study","volume":"14","author":"G Shlomai","year":"2015","journal-title":"Cardiovasc Diabetol"},{"issue":"01","key":"ref43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12959-024-00626-3","article-title":"Association of elevated circulating monocyte-platelet aggregates with hypercoagulability in patients with nephrotic syndrome","volume":"22","author":"S P Na","year":"2024","journal-title":"Thromb J"},{"issue":"14","key":"ref44","doi-asserted-by":"crossref","first-page":"11739","DOI":"10.3390\/ijms241411739","article-title":"The effects of statins, ezetimibe, PCSK9-inhibitors, inclisiran, and icosapent ethyl on platelet function","volume":"24","author":"A Di Costanzo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000093226","article-title":"Low-density lipoprotein-lowering medication and platelet function","volume":"35","author":"P Ferroni","year":"2006","journal-title":"Pathophysiol Haemost Thromb"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-0042-1758655","article-title":"P2Y12 inhibition suppresses proinflammatory platelet-monocyte interactions","volume":"123","author":"C C Rolling","year":"2023","journal-title":"Thromb Haemost"},{"issue":"03","key":"ref47","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1067\/mcp.2003.13","article-title":"Clopidogrel but not aspirin reduces P-selectin expression and formation of platelet-leukocyte aggregates in patients with atherosclerotic vascular disease","volume":"73","author":"U Klinkhardt","year":"2003","journal-title":"Clin Pharmacol Ther"},{"issue":"05","key":"ref48","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/cyto.b.21363","article-title":"The influence of different anticoagulants and time-delayed sample processing and measurements on human monocyte subset and monocyte-platelet aggregate analyses","volume":"92","author":"W J Ji","year":"2017","journal-title":"Cytometry B Clin Cytom"},{"issue":"05","key":"ref49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3390\/biomedicines9050445","article-title":"Laboratory monitoring of direct oral anticoagulants (DOACs)","volume":"9","author":"C Dunois","year":"2021","journal-title":"Biomedicines"},{"issue":"06","key":"ref50","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1160\/TH15-11-0847","article-title":"Argatroban pharmacokinetics and pharmacodynamics in critically ill cardiac surgical patients with suspected heparin-induced thrombocytopenia","volume":"115","author":"C Keyl","year":"2016","journal-title":"Thromb Haemost"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2747-8963.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:16Z","timestamp":1764979216000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2747-8963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,5]]},"references-count":49,"URL":"https:\/\/doi.org\/10.1055\/a-2747-8963","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,5]]}}}