{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:02:48Z","timestamp":1768644168805,"version":"3.49.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e\n                        Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento\n                        Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de\n                        Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigated the protective effect of alkaloid boldine against\n                        diclofenac-induced kidney damage in normotensive female rats.<\/jats:p>\n                  <jats:p>Animals were divided into three groups: naive, vehicle+diclofenac (50 mg\/kg),\n                        and boldine+diclofenac (boldine 0.1 mg\/kg+diclofenac 50 mg\/kg). Treatments\n                        were administered orally once daily for 2 days.<\/jats:p>\n                  <jats:p>The vehicle+diclofenac group showed reduced urinary volume and sodium\n                        excretion. In contrast, the boldine+diclofenac group restored both\n                        parameters to levels similar to the naive group. Other urinary electrolytes\n                        indicated imbalance in diclofenac-treated animals, regardless of boldine\n                        co-treatment. Plasma analysis showed no alterations. Kidney tissue from\n                        diclofenac-treated groups revealed increased glutathione and decreased lipid\n                        hydroperoxides. Histology showed that vehicle+diclofenac resulted in a\n                        reduction in glomerular size, thickening of Bowman\u2019s capsule, and mesangial\n                        disarray, while these changes were less pronounced with boldine\n                        co-treatment. Molecular docking analysis indicated that boldine may interact\n                        with important proteins related to renal hemodynamics, sodium regulation,\n                        and inflammatory processes pointing to a multi-target mechanism.<\/jats:p>\n                  <jats:p>Boldine attenuated renal damage induced by diclofenac, improving urinary\n                        parameters and reducing histological alterations. Further studies are\n                        necessary to elucidate its protective mechanisms and impact on renal\n                        hemodynamics.<\/jats:p>","DOI":"10.1055\/a-2749-3102","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:47:21Z","timestamp":1764290841000},"page":"35-42","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effect of Boldine Against Diclofenac-Induced Renal Damage\n                    in Rats"],"prefix":"10.1055","volume":"76","author":[{"given":"Lu\u00edsa Nath\u00e1lia Bolda","family":"Mariano","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas,\n                    Universidade do Vale do Itajai\u0301 (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helo\u00edsa Roberti","family":"Cristofolini","sequence":"additional","affiliation":[{"name":"Medical course, Universidade do Vale do Itajai\u0301\n                    (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita de C\u00e1ssia","family":"Vilhena da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas,\n                    Universidade do Vale do Itajai\u0301 (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anelise Fel\u00edcio","family":"Macarini","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas,\n                    Universidade do Vale do Itajai\u0301 (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdir","family":"Cechinel Filho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas,\n                    Universidade do Vale do Itajai\u0301 (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-5642","authenticated-orcid":false,"given":"Priscila","family":"de Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas,\n                    Universidade do Vale do Itajai\u0301 (UNIVALI), Itaja\u00ed, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.2223\/JPED.1560","article-title":"Nonsteroidal anti-inflammatory drugs: Cyclooxygenase 2 inhibitors","volume":"82","author":"MO E Hil\u00e1rio","year":"2006","journal-title":"J Pediatr (Rio J)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/03009740310004766","article-title":"Selective cyclooxygenase-2 inhibitors: similarities 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Diclofenac"],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":27,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,1,16]]},"published-print":{"date-parts":[[2026,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2749-3102","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]}}}