{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:18:24Z","timestamp":1787872704149,"version":"build-2784847793"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Concomitant cryoablation is routinely performed in patients with atrial fibrillation who undergo minimally invasive atrioventricular (AV) valve surgery. While biomarker thresholds for postoperative myocardial infarction (pMI) are established in coronary artery bypass surgery, no clear thresholds exist after concomitant cryoablation in endoscopic valve surgery. This study aimed to analyze the perioperative cardiac biomarker release patterns in this patient cohort and to evaluate the applicability of SCAI-defined pMI thresholds.<\/jats:p>\n                  <jats:p>We retrospectively analyzed patients who underwent endoscopic AV valve surgery from 2018 to 2024, comparing those with cryoablation (n\u2009=\u2009165; mean age: 66.5\u2009\u00b1\u20099.5 years) to those without (n\u2009=\u2009513; mean age: 62.4\u2009\u00b1\u200912.0 years). Perioperative creatine kinase\u2013myocardial band (CK-MB) and troponin T (TnT) levels were measured before surgery, at 1 and 4\u2009hours after surgery, and on postoperative day 1 (1POD). In-hospital outcomes were also assessed.<\/jats:p>\n                  <jats:p>Cryoablation significantly increased CK-MB (6.4\u2009\u00d7\u2009ULN vs. 2.4\u2009\u00d7\u2009ULN, p\u2009&lt;\u20090.001) and TnT (257\u2009\u00d7\u2009ULN vs. 80\u2009\u00d7\u2009ULN, p\u2009&lt;\u20090.001). Compared with SCAI pMI criteria (CK-MB\u2009&gt;\u200910\u2009\u00d7\u2009ULN; TnT\u2009&gt;\u200970\u2009\u00d7\u2009ULN), CK-MB remained below the threshold, while TnT exceeded it in most cases (p\u2009&lt;\u20090.05). Despite these elevations, clinical pMI was rare (two cases vs. three cases). In-hospital mortality did not differ significantly between the groups (1.2% vs. 1.6%; p\u2009=\u20091.000).<\/jats:p>\n                  <jats:p>Cryoablation during minimally invasive AV valve surgery markedly increases postoperative cardiac biomarkers without higher clinical pMI rates. Procedure-specific biomarker thresholds and validation of SCAI criteria are essential for accurate diagnosis and patient management.<\/jats:p>","DOI":"10.1055\/a-2749-9396","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:15:28Z","timestamp":1763597728000},"page":"460-467","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative Cardiac Biomarker Release After Minimally Invasive AV-Valve Surgery with or without Cryoablation"],"prefix":"10.1055","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-9836","authenticated-orcid":false,"given":"Jang-Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Clinic, Germany, University Hospital of Giessen, Bad Nauheim, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara M.","family":"Berberoglu","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Clinic, Germany, University Hospital of Giessen, Bad Nauheim, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majd","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Clinic, Germany, University Hospital of Giessen, Bad Nauheim, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Sch\u00f6nburg","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Clinic, Germany, University Hospital of Giessen, Bad Nauheim, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong-Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Clinic, Germany, University Hospital of Giessen, Bad Nauheim, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver J.","family":"Liakopoulos","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Kerckhoff Clinic, Germany, University Hospital of Giessen, Bad Nauheim, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/ejcts\/ezv312","article-title":"State of the art for approaching the mitral valve: sternotomy, minimally invasive or total endoscopic robotic?","volume":"48","author":"M Glauber","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.ejcts.2008.07.057","article-title":"Minimally invasive mitral valve surgery: a systematic review and meta-analysis","volume":"34","author":"P Modi","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"issue":"S 01","key":"ref3","first-page":"II48","article-title":"Mitral valve surgery can now routinely be performed endoscopically","volume":"108","author":"F P Casselman","year":"2003","journal-title":"Circulation"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.21037\/acs-2023-afm-21","article-title":"Concomitant atrial fibrillation ablation in minimally invasive cardiac surgery","volume":"13","author":"A Tjon Joek Tjien","year":"2024","journal-title":"Ann Cardiothorac Surg"},{"issue":"08","key":"ref5","first-page":"672","article-title":"Freezing equals freezing? 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