{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:47:07Z","timestamp":1776725227425,"version":"3.51.2"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1055\/a-2751-2903","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:59:34Z","timestamp":1773791974000},"page":"327-329","source":"Crossref","is-referenced-by-count":0,"title":["Ocular Ochronosis in Alkaptonuria: Two Case Reports"],"prefix":"10.1055","volume":"243","author":[{"given":"Charoun","family":"Chousein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6608-3895","authenticated-orcid":false,"given":"Felix","family":"Gabathuler","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Zweifel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-4991","authenticated-orcid":false,"given":"Daniel","family":"Barthelmes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Blaser","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1056\/NEJMoa021736","article-title":"Natural history of alkaptonuria","volume":"347","author":"C Phornphutkul","year":"2002","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1177\/0004563219879957","article-title":"Alkaptonuria \u2013 Many questions answered, further challenges beckon","volume":"57","author":"A S Davison","year":"2020","journal-title":"Ann Clin Biochem"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2415-14-12","article-title":"On the ocular findings in ochronosis: a systematic review of literature","volume":"14","author":"M Lindner","year":"2014","journal-title":"BMC Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.ymgme.2011.04.016","article-title":"A 3-year randomized therapeutic trial of nitisinone in alkaptonuria","volume":"103","author":"W J Introne","year":"2011","journal-title":"Mol Genet Metab"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/S2213-8587(20)30228-X","article-title":"Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial","volume":"8","author":"L R Ranganath","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1136\/annrheumdis-2014-206033","article-title":"Suitability of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment","volume":"75","author":"L R Ranganath","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.metabol.2004.12.017","article-title":"Use of nitisinone in patients with alkaptonuria","volume":"54","author":"P Suwannarat","year":"2005","journal-title":"Metabolism"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/jimd.12172","article-title":"Dietary restriction of tyrosine and phenylalanine lowers tyrosinemia associated with nitisinone therapy of alkaptonuria","volume":"43","author":"J H Hughes","year":"2020","journal-title":"J Inherit Metab Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/8904_2014_307","article-title":"Reversible keratopathy due to hypertyrosinaemia following intermittent low-dose nitisinone in alkaptonuria: a case report","volume":"17","author":"R MK Stewart","year":"2014","journal-title":"JIMD Rep"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1001\/archopht.118.5.724","article-title":"Ocular Manifestations of Alkaptonuric Ochronosis","volume":"118","author":"J Cheskes","year":"2000","journal-title":"Arch Ophthalmol"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2751-2903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:34:42Z","timestamp":1776724482000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2751-2903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":10,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,4,20]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2751-2903","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}