{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T01:07:46Z","timestamp":1764810466876,"version":"3.46.0"},"reference-count":8,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg Rep"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary melanocytic tumors of the central nervous system (CNS) are rare neoplasms that range from benign melanocytomas to aggressive malignant melanomas. Although meningeal melanocytomas are generally considered indolent lesions, malignant transformation and distant metastasis can occur.<\/jats:p>\n                  <jats:p>We report the case of a 33-year-old male with a bulbopontine meningeal melanocytoma who developed systemic metastases, culminating in a fatal outcome. Despite initial histopathologic features of benignity and absence of BRAF mutation, the lesion showed aggressive behavior.<\/jats:p>\n                  <jats:p>This case underscores the diagnostic pitfalls associated with primary CNS melanocytic tumors and highlights the importance of long-term vigilance, even for histologically benign lesions.<\/jats:p>","DOI":"10.1055\/a-2753-9601","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T01:04:36Z","timestamp":1764810276000},"page":"e249-e252","source":"Crossref","is-referenced-by-count":0,"title":["Aggressive Clinical Course and Malignant Transformation of a Meningeal Melanocytoma of the Pontomedullary Region: Diagnostic and Therapeutic Implications"],"prefix":"10.1055","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0614-6719","authenticated-orcid":false,"given":"Oyku","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet A.","family":"Inan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gazi University Faculty of Medicine, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muammer M.","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\/Head and Neck Surgery, Gazi University Faculty of Medicine, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5733-7542","authenticated-orcid":false,"given":"Emrah","family":"Celtikci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"D N Louis","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/bpa.12241","article-title":"Primary melanocytic tumors of the CNS: a review with focus on molecular aspects","volume":"25","author":"H VN K\u00fcsters-Vandevelde","year":"2015","journal-title":"Brain Pathol"},{"issue":"20","key":"ref3","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1056\/NEJMicm2212333","article-title":"Primary diffuse meningeal melanomatosis","volume":"388","author":"L Wen","year":"2023","journal-title":"N Engl J 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Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2753-9601.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T01:04:39Z","timestamp":1764810279000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2753-9601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":8,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2025,10,3]]},"published-print":{"date-parts":[[2025,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2753-9601","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6358","2193-6366"],"issn-type":[{"value":"2193-6358","type":"print"},{"value":"2193-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}