{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T23:08:24Z","timestamp":1776121704377,"version":"3.50.1"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fetal intra-abdominal cystic lesions are relatively common. The morphological\n                        assessment of the cyst, determination of the fetal sex, and evaluation of\n                        its relationship with adjacent structures can guide the differential\n                        diagnosis. The aims of this study were to evaluate the diagnostic accuracy\n                        of ultrasound in detecting fetal intra-abdominal cysts and to develop a\n                        predictive model for spontaneous regression or persistence.<\/jats:p>\n                  <jats:p>We retrospectively reviewed 61 fetuses with intra-abdominal cystic lesions\n                        between October 2020 and November 2024. Maternal-fetal characteristics,\n                        ultrasonographic features of cystic lesions, and postnatal outcomes were\n                        collected.<\/jats:p>\n                  <jats:p>A total of 61 fetuses with intra-abdominal cysts were analyzed. Spontaneous\n                        regression occurred in 15 cases (24.6%) during the prenatal period, while 46\n                        (75.4%) persisted postnatally. Mean cyst size was 24.1 mm (+\/\u2013\u200911.2) in the\n                        regression group and 40 mm (\u2013\u200916.5) in the persistent group. Cysts that\n                        regressed were diagnosed at a median of 25 weeks, whereas persistent cases\n                        were diagnosed at 30 weeks. In univariate logistic regression analyses,\n                        gestational age at diagnosis and initial cyst diameter were identified as\n                        significant predictors of spontaneous prenatal regression (p=0.006, 0.003,\n                        respectively).<\/jats:p>\n                  <jats:p>Prenatal US is an effective tool to accurately diagnose fetal intra-abdominal\n                        cysts. The combination of a lower gestational age at diagnosis and a smaller\n                        initial cyst diameter is associated with a higher likelihood of spontaneous\n                        prenatal regression. An evaluation based on gestational age at diagnosis and\n                        ultrasound characteristics with a primary focus on the largest diameter of\n                        the cystic lesions may help to guide parental counseling.<\/jats:p>","DOI":"10.1055\/a-2754-0562","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:10:11Z","timestamp":1765325411000},"page":"115-121","source":"Crossref","is-referenced-by-count":0,"title":["Antenatal course and clinical outcomes of fetal intra-abdominal\n                    cystic lesions: a single tertiary center experience"],"prefix":"10.1055","volume":"230","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5937-0220","authenticated-orcid":false,"given":"Verda","family":"Alpay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology,\n                    Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kubra Kurt","family":"Bilirer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology,\n                    Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bar\u0131\u015f","family":"Boza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology,\n                    Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firat","family":"Ersan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology,\n                    Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology,\n                    Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3892\/etm.2016.3948","article-title":"Ultrasound and differential diagnosis of fetal abdominal cysts","volume":"13","author":"C Y Tu","year":"2017","journal-title":"Exp Ther Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3109\/14767058.2015.1059812","article-title":"Fetal intra-abdominal cysts: Accuracy and predictive value of prenatal\n                    ultrasound","volume":"29","author":"V D Catania","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1515\/jpm-2018-0311","article-title":"Fetal abdominal cysts: Antenatal course and postnatal outcomes","volume":"47","author":"E Sanna","year":"2019","journal-title":"J Perinat Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/uog.12552","article-title":"Outcome of first-trimester fetal abdominal cysts: cohort study and review of the\n                    literature","volume":"43","author":"A Khalil","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1080\/01443615.2019.1576601","article-title":"Prenatal diagnosis and prognosis assessment of fetal intra-abdominal cystic\n                    lesions: a retrospective study in 264 cases","volume":"39","author":"M Lv","year":"2019","journal-title":"J Obstet Gynaecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"105102","DOI":"10.1016\/j.earlhumdev.2020.105102","article-title":"Antenatally detected abdominal cyst: Does cyst size and nature determine\n                    postnatal symptoms and outcome?","volume":"147","author":"S Lewis","year":"2020","journal-title":"Early Hum Dev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"W1","DOI":"10.2214\/AJR.11.6642","article-title":"Focal cystic abdominal masses in pediatric patients","volume":"199","author":"S H Ranganath","year":"2012","journal-title":"AJR Am J Roentgenol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1002\/jum.15963","article-title":"Fetal abdominal cystic masses: Clinical spectrum and prenatal ultrasound\n                    diagnosis","volume":"41","author":"Y Wang","year":"2022","journal-title":"J Ultrasound Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1159\/000510814","article-title":"Fetal non-ovarian abdominopelvic cystic lesions: A single-center report","volume":"47","author":"S A Eyerly-Webb","year":"2020","journal-title":"Fetal Diagn Ther"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/pd.2028","article-title":"Intra-abdominal masses: Prenatal differential diagnosis and management","volume":"28","author":"J Hyett","year":"2008","journal-title":"Prenat Diagn"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/aogs.14584","article-title":"Fetal abdominal cysts: Predicting adverse outcomes","volume":"102","author":"P Garcia-Aguilar","year":"2023","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e30962","DOI":"10.1097\/MD.0000000000030962","article-title":"Clinical outcomes of fetal ovarian masses diagnosed by prenatal ultrasonography\n                    and literature review","volume":"101","author":"J Min","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000495506","article-title":"Differences in origin and outcome of intra-abdominal cysts in male and female\n                    fetuses","volume":"46","author":"M Husen","year":"2019","journal-title":"Fetal Diagn Ther"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/pd.4614","article-title":"Prenatal diagnosis of intra-abdominal cystic lesions by fetal ultrasonography:\n                    diagnostic agreement between prenatal and postnatal diagnosis","volume":"35","author":"G Marchitelli","year":"2015","journal-title":"Prenat Diagn"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/pd.4590","article-title":"Does prenatal MRI enhance fetal diagnosis of intra-abdominal cysts?","volume":"35","author":"F Hugele","year":"2015","journal-title":"Prenat Diagn"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"319","DOI":"10.4172\/2161-0932.1000319","article-title":"Fetal abdominal cysts: prenatal diagnosis and management","volume":"5","author":"A A\u00e7\u0131kg\u00f6z","year":"2015","journal-title":"Gynecol Obstet (Sunnyvale)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000318191","article-title":"Perinatal outcomes of fetal abdominal cysts and comparison of prenatal and\n                    postnatal diagnoses","volume":"28","author":"O Ozyuncu","year":"2010","journal-title":"Fetal Diagn Ther"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00383-014-3635-2","article-title":"Post-natal outcomes of antenatally diagnosed intra-abdominal cysts: A 22-year\n                    single-institution series","volume":"31","author":"H S Thakkar","year":"2015","journal-title":"Pediatr Surg Int"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1055\/s-0038-1668576","article-title":"A systematic review of prenatally diagnosed intra-abdominal enteric duplication\n                    cysts","volume":"29","author":"A S Fahy","year":"2019","journal-title":"Eur J Pediatr Surg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/uog.6142","article-title":"Fetal abdominal cysts in the first trimester: prenatal detection and clinical\n                    significance","volume":"32","author":"W Sepulveda","year":"2008","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1015678","DOI":"10.3389\/fped.2022.1015678","article-title":"Outcomes of sonographically-suspected fetal intra-abdominal cysts: Surgical\n                    intervention, conservative management and spontaneous regression","volume":"10","author":"S Gai","year":"2022","journal-title":"Front Pediatr"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2754-0562.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:32:56Z","timestamp":1776119576000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2754-0562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":21,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2026,4,13]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2754-0562","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]}}}