{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:25:17Z","timestamp":1769721917535,"version":"3.49.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Horizon Europe Innovation Action","award":["Grant Agreement No. 101137227"],"award-info":[{"award-number":["Grant Agreement No. 101137227"]}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"crossref","award":["Ricerca Corrente 2021"],"award-info":[{"award-number":["Ricerca Corrente 2021"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:p>The use of low-molecular-weight heparin (LMWH) and aspirin during pregnancy is increasing, yet robust clinical trial evidence supporting their efficacy remains limited.<\/jats:p>\n                  <jats:p>In a multicenter prospectively enrolled cohort study, we evaluated the prescription patterns and associated maternal\u2013fetal outcomes of antithrombotic therapy in 2,622 women admitted for delivery across three Italian obstetric centers between January 2022 and November 2023. Data were collected on conception methods, administration details (timing, dose, indication) of LMWH and low-dose aspirin (LDA), and maternal\u2013fetal outcomes from admission to postpartum discharge. Data on prescription of antithrombotic drugs were available for 1,898 women.<\/jats:p>\n                  <jats:p>Among 1,898 women with available data, 157 (8.3%) received LDA (100\u2009mg\/day) and 746 (39.3%) received LMWH (49 during pregnancy and 697 in the postpartum period). Predictors of LMWH use included prior cesarean (OR 3.1, 95% CI 1.7\u20135.8), preterm delivery (OR 3.8, 95% CI 1.7\u20138.9), pregnancy loss (OR 2.7, 95% CI 1.5\u20134.9), and assisted conception (OR 14.6, 95% CI 2.8\u201376.5). LDA use was associated with pregnancy loss (OR 2.1, 95% CI 1.4\u20133.0), ART (OR 4.7, 95% CI 2.2\u201310.2), and LMWH co-administration (OR 2.5, 95% CI 1.1\u20135.5). Postpartum LMWH use was primarily associated with cesarean delivery. Postpartum hemorrhage occurred in 2.4% of cases, with no significant difference in those receiving LDA or LMWH.<\/jats:p>\n                  <jats:p>These findings reflect current real-world prescribing practices and highlight key maternal characteristics influencing antithrombotic therapy decisions. The study underscores the importance of evidence-based approaches in the use of LMWH and LDA during pregnancy, particularly in high-risk populations, to improve maternal\u2013fetal outcomes while minimizing unnecessary exposure to therapies with uncertain benefit.<\/jats:p>","DOI":"10.1055\/a-2755-2565","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:20:19Z","timestamp":1764202819000},"source":"Crossref","is-referenced-by-count":1,"title":["Identifying Thromboprophylaxis and Aspirin Use in Pregnancy: Predictors and Maternal Outcomes\u2014the Italian MoMs Study"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8980-9783","authenticated-orcid":false,"given":"Elvira","family":"Grandone","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, University of Foggia, Foggia, Italy"},{"name":"Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni R., Foggia, Italy"},{"name":"Department of Obstetrics, Gynaecology and Perinatal Medicine, The First I.M. Sechenov Moscow State Medical University, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Mastroianno","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni R., Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felice","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Cicerone","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donatella","family":"Colaizzo","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni R., Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Latino","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni R., Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Lo Muzio","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Bettocchi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Mirabella","sequence":"additional","affiliation":[{"name":"Scientific Direction, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni R., Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Ostuni","sequence":"additional","affiliation":[{"name":"Department of Surgical and Medical Science, Anesthesia and Intensive Care, University of Foggia, Policlinico Riuniti di Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"de Laurenzo","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni R., Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Gorgoglione","sequence":"additional","affiliation":[{"name":"Immunohematology and Transfusion Medicine Service, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Palladino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Bari, Bari, Italy"},{"name":"Anesthesia and Intensive Care, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni Rotondo, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Vaira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Vimercati","sequence":"additional","affiliation":[{"name":"Immunohematology and Transfusion Medicine Service, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore","family":"Cicinelli","sequence":"additional","affiliation":[{"name":"Immunohematology and Transfusion Medicine Service, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni Rotondo, Foggia, Italy"},{"name":"Division of Cardiovascular Medicine and Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Kaldoudi","sequence":"additional","affiliation":[{"name":"YNHH\/Yale Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Nappi","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department, University of Foggia, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Piazza","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza\u201d, S. Giovanni Rotondo, Foggia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Margaglione","sequence":"additional","affiliation":[{"name":"Medical Physics and Medical Informatics, Democritus University of Thrace, Komotini, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1161\/HYPERTENSIONAHA.118.11718","article-title":"Preeclampsia prevention using routine versus screening test-indicated aspirin in low-risk women","volume":"72","author":"F Mone","year":"2018","journal-title":"Hypertension"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1055\/s-0041-1735628","article-title":"Thrombophilia, antithrombotic therapy, and recurrent pregnancy loss: a call for pragmatism in the face of unknowns","volume":"39","author":"G Piazza","year":"2021","journal-title":"Semin Reprod Med"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/humrep\/deab248","article-title":"Reply: The pathway to the \u201ctruth\u201d in the study of recurrent pregnancy loss and thrombophilia","volume":"37","author":"E Grandone","year":"2021","journal-title":"Hum Reprod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0140-6736(23)00693-1","article-title":"Heparin for women with recurrent miscarriage and inherited thrombophilia (ALIFE2): an international open-label, randomised controlled trial","volume":"402","author":"S Quenby","year":"2023","journal-title":"Lancet"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1182\/asheducation-2016.1.243","article-title":"Venous thromboembolism and stroke in pregnancy","volume":"2016","author":"K McLean","year":"2016","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1097\/AOG.0000000000002708","article-title":"743. 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