{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:47:41Z","timestamp":1776725261760,"version":"3.51.2"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Acute syphilitic posterior placoid chorioretinitis (ASPPC) is a pathognomonic manifestation of ocular syphilis. Although formerly considered as being uncommon, its incidence appears to be increasing in recent years. Advances in multimodal imaging, particularly spectral domain optical coherence tomography (SD-OCT), have provided new insights into its pathophysiology and natural course.<\/jats:p>\n                  <jats:p>Case Series We present three cases of ASPPC with multimodal imaging and long-term follow-up. Clinical history, fundus findings, fluorescein and indocyanine green angiography, fundus autofluorescence and SD-OCT were reviewed. All patients exhibited systemic symptoms prior to ocular involvement and presented with bilateral uveitis, vitritis, and placoid yellowish macular lesions. SD-OCT demonstrated granular RPE thickening, ellipsoid zone disruption, followed by RPE-nodular elevations. These findings likely reflect an inflammatory response in the choroid and choriocapillaris, causing vascular alterations and metabolic impairment of the RPE and the outer retina. With appropriate systemic antibiotic therapy, OCT findings progressively normalised in parallel with gradual visual acuity improvement over 1\u200a\u2013\u200a2 months.<\/jats:p>\n                  <jats:p>Conclusions These cases illustrate the characteristic clinical features of ASPPC and highlight the role of SD-OCT in both diagnosis and follow-up. Prompt recognition of ocular syphilis remains crucial and particularly rewarding for the ophthalmologist, who is often the first to recognise ocular syphilis, thereby preventing life-threatening systemic complications and achieving successful treatment of ocular manifestation.<\/jats:p>","DOI":"10.1055\/a-2760-5010","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T23:50:22Z","timestamp":1769730622000},"page":"428-433","source":"Crossref","is-referenced-by-count":0,"title":["Crucial Role of Spectral Domain OCT in the Diagnosis and Follow-up of Acute Syphilitic Posterior Placoid Chorioretinitis (ASPPC) \u2013 a Case Series"],"prefix":"10.1055","volume":"243","author":[{"given":"Angelica","family":"Rizzato","sequence":"additional","affiliation":[{"name":"Ophthalmology, Vista Klinik AG, Binningen, Switzerland"},{"name":"Ophthalmology, University Hospital Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Ophthalmology, Vista Klinik AG, Binningen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Weisskopf","sequence":"additional","affiliation":[{"name":"Ophthalmology, Vista Klinik AG, Binningen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Hatz-Wurziger","sequence":"additional","affiliation":[{"name":"Ophthalmology, Vista Klinik AG, Binningen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Katamay","sequence":"additional","affiliation":[{"name":"Ophthalmology, Vista Klinik AG, Binningen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asan","family":"Kochkorov","sequence":"additional","affiliation":[{"name":"Ophthalmology, Vista Klinik AG, Binningen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1056\/NEJMra2216081","article-title":"Eye infections","volume":"389","author":"M L Durand","year":"2023","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e410","DOI":"10.1093\/milmed\/usad238","article-title":"A case series of ocular syphilis cases at a military treatment facility from 2020 to 2021","volume":"189","author":"M Kautz","year":"2024","journal-title":"Mil Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12348-022-00286-2","article-title":"Acute syphilitic posterior placoid chorioretinitis: when the great mimicker cannot pretend any more; new insight of an old acquaintance","volume":"12","author":"P Neri","year":"2022","journal-title":"J Ophthalmic Inflamm Infect"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1016\/S0161-6420(90)32418-1","article-title":"Acute syphilitic posterior placoid chorioretinitis","volume":"97","author":"J DM Gass","year":"1990","journal-title":"Ophthalmology"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1080\/09273948.2025.2511129","article-title":"The rise of syphilitic placoid chorioretinitis: a literature review with data from 286 published cases","volume":"33","author":"N Jones","year":"2025","journal-title":"Ocul Immunol Inflamm"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1097\/IAE.0b013e3182993f11","article-title":"Spectral domain optical coherence tomography findings in patients with acute syphilitic posterior placoid chorioretinopathy","volume":"34","author":"F Pichi","year":"2014","journal-title":"Retina"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1080\/09273948.2021.1928712","article-title":"Spectrum of syphilitic chorioretinitis and its evolution based on multimodal imaging","volume":"30","author":"J Artaechevarria Artieda","year":"2022","journal-title":"Ocul Immunol Inflamm"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000500239","article-title":"Angiography and en face optical coherence tomography findings in acute syphilitic posterior placoid chorioretinopathy","volume":"10","author":"A Moll-Udina","year":"2019","journal-title":"Case Rep Ophthalmol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.oret.2023.07.014","article-title":"Clinical characteristics and visual outcomes of acute syphilitic posterior placoid chorioretinopathy","volume":"7","author":"D Mirzania","year":"2023","journal-title":"Ophthalmol Retina"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1097\/IAE.0b013e31825f3851","article-title":"Acute syphilitic posterior placoid chorioretinitis: report of a case series and comprehensive review of the literature","volume":"32","author":"C M Eandi","year":"2012","journal-title":"Retina"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e8376","DOI":"10.1097\/MD.0000000000008376","article-title":"Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: a retrospective case study","volume":"96","author":"E J Zhu","year":"2017","journal-title":"Medicine (Baltimore)"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2760-5010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:35:34Z","timestamp":1776724534000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2760-5010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":11,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,4,20]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2760-5010","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]}}}