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Focused ultrasound-mediated drug delivery is particularly interesting in fields in which high selectivity and localized action are needed to avoid unwanted side effects or therapy failure, for example with antineoplastic and antimicrobial drugs.<\/jats:p>\n                  <jats:p>For this paper, a literature search of the PubMed database was performed using the keywords \u201cfocused ultrasound\u201d and \u201cmusculoskeletal applications\u201d.<\/jats:p>\n                  <jats:p>This review article presents an overview of the currently available technologies for focused ultrasound-mediated drug delivery and their possible musculoskeletal applications, along with a discussion of recent promising preclinical and clinical results.<\/jats:p>","DOI":"10.1055\/a-2760-5392","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:05:22Z","timestamp":1769817922000},"page":"861-871","source":"Crossref","is-referenced-by-count":0,"title":["Focused ultrasound-mediated drug delivery systems: a technological overview, possible musculoskeletal applications, and future directions"],"prefix":"10.1055","volume":"198","author":[{"given":"Rebecca","family":"Sassi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Rizzoli, Italy","place":["Bologna"],"department":["Diagnostic and Interventional Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Gazzotti","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Rizzoli, Italy","place":["Bologna"],"department":["Diagnostic and Interventional Radiology"]},{"name":"University of Bologna, Italy","place":["Bologna"],"department":["Department of Medical and Surgical Sciences (DIMEC)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6483-7139","authenticated-orcid":false,"given":"Maria Pilar","family":"Aparisi G\u00f3mez","sequence":"additional","affiliation":[{"name":"Te Whatu Ora Health New Zealand Te Toka Tumai Auckland, New Zealand","place":["Auckland"],"department":["Department of Radiology"]},{"name":"The University of Auckland Faculty of Medical and Health Sciences, Auckland, New Zealand","place":["Auckland"],"department":["Department of Anatomy and Medical Imaging"]},{"name":"Instituto Musculoesquel\u00e9tico Europeo (IMSKE), Spain","place":["Valencia"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza Maria","family":"Donati","sequence":"additional","affiliation":[{"name":"Alma Mater Studiorum Universit\u00e0 di Bologna, Emilia-Romagna, Italy","place":["Bologna"],"department":["Department of Experimental, Diagnostic and Specialty Medicine-DIMES"]},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico di Sant'Orsola, Emilia-Romagna, Italy","place":["Bologna"],"department":["Radiation 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