{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:57:12Z","timestamp":1781135832397,"version":"3.54.1"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2026,6]]},"abstract":"Abstract<\/jats:title>\n The rationale for intranodular steroid injections in Dupuytren\u2019s disease was\n based on clinical and experimental studies demonstrating the inhibitory effect\n of steroids on connective tissue proliferation and on degradation of mature\n collagen in hypertrophic scars. This prompted clinicians to use steroid\n injections to treat Dupuytren\u2019s nodules.<\/jats:p>\n Objective\u2002This study aimed to evaluate the effect of steroid injections\n into Dupuytren\u2019s nodules on inhibiting early-stage disease progression.<\/jats:p>\n Materials and methods\u2002A total of 28 patients (16 men and 12 women; mean\n age: of 61 y) with early-stage Dupuytren\u2019s disease in 33 hands received 2 or 3\n intranodular steroid injections (methylprednisolone or betamethasone) at 2-week\n intervals. The patients were followed for 14 months on average (range: 12\u201316 mo)\n by a phone call.<\/jats:p>\n Results\u2002A series of steroid injections resulted in pain reduction in all\n 17 symptomatic nodules. Softening of the nodule was observed in 22 hands (67%),\n softening and reduction of size in 7 hands (21%), and no changes in 4 hands\n (12%). No cases of disease progression and no complications were recorded.<\/jats:p>\n Conclusions\u2002Intralesional steroid injections may be an effective\n first-line treatment for early-stage Dupuytren\u2019s disease, particularly in\n symptomatic nodules.<\/jats:p>","DOI":"10.1055\/a-2760-7447","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:51Z","timestamp":1768867251000},"page":"220-224","source":"Crossref","is-referenced-by-count":0,"title":["An Assessment of the Effect of Intranodular Steroid Injection on\n Inhibiting the Progression of Early-Stage Dupuytren&apos;s Disease: A\n Preliminary Report"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8299-4525","authenticated-orcid":false,"given":"Andrzej","family":"Zyluk","sequence":"additional","affiliation":[{"name":"Department of General and Hand Surgery, Pomeranian Medical University,\n Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"Flicinski","sequence":"additional","affiliation":[{"name":"Department of General and Hand Surgery, Pomeranian Medical University,\n Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1097\/01.prs.0000438455.37604.0f","article-title":"A systematic review and meta-analysis on the prevalence of Dupuytren\u2019s disease\n in the general population of western countries","volume":"133","author":"R Lanting","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1080\/030097401750065292","article-title":"Eighteen years follow-up study of the clinical manifestations and progression of\n Dupuytren\u2019s disease","volume":"30","author":"K G Gudmundsson","year":"2001","journal-title":"Scand J Rheumatol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1177\/17531934221131373","article-title":"Treatments for early-stage Dupuytren\u2019s disease: an evidence-based approach","volume":"48","author":"J Nanchahal","year":"2023","journal-title":"J Hand Surg Eur"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1530\/EOR-23-0056","article-title":"Molecular genetics of Dupuytren\u2019s contracture","volume":"9","author":"S Aissvarya","year":"2024","journal-title":"EFORT Open Rev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1177\/1753193412471502","article-title":"Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren\u2019s\n disease","volume":"38","author":"A Zyluk","year":"2013","journal-title":"J Hand Surg Eur"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.5604\/01.3001.0016.0058","article-title":"Dupuytrens disease - whats new: a review","volume":"95","author":"A Zyluk","year":"2022","journal-title":"Pol Przegl Chir"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.jhsa.2021.07.005","article-title":"Dupuytren contractures: an update of recent literature","volume":"46","author":"C Boe","year":"2021","journal-title":"J Hand Surg Am"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1302\/0301-620X.103B4.BJJ-2020-1364.R1","article-title":"Limited progression of subclinical Dupuytren\u2019s disease","volume":"103-B","author":"B A van den Berge","year":"2021","journal-title":"Bone Joint J"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1186\/s12891-016-1200-y","article-title":"Systematic review of non-surgical treatments for early Dupuytren\u2019s disease","volume":"17","author":"C Ball","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1053\/jhsu.2000.18493","article-title":"The injection of nodules of Dupuytren\u2019s disease with triamcinolone\n acetonide","volume":"25","author":"L D Ketchum","year":"2000","journal-title":"J Hand Surg Am"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1177\/1753193417690961","article-title":"Long- term follow-up of Dupuytren disease after injection of triamcinolone\n acetonide in Chinese patients in Taiwan","volume":"42","author":"C Y Yin","year":"2017","journal-title":"J Hand Surg Eur"},{"key":"ref12","first-page":"e42","article-title":"Corticosteroid injection in the management of Dupuytren nodules: a review of the\n literature","volume":"15","author":"A Sood","year":"2015","journal-title":"Eplasty"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e278","DOI":"10.1097\/GOX.0000000000000249","article-title":"The rationale for treating the nodule in Dupuytren\u2019s disease","volume":"2","author":"L D Ketchum","year":"2015","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.jhsa.2023.02.003","article-title":"Pharmacotherapies in dupuytren disease: current and novel strategies","volume":"48","author":"A G Lambi","year":"2023","journal-title":"J Hand Surg Am"}],"container-title":["Handchirurgie \u00b7 Mikrochirurgie \u00b7 Plastische Chirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2760-7447.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T23:04:26Z","timestamp":1781132666000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2760-7447"}},"subtitle":["Eine Bewertung der Wirkung einer intranodul\u00e4ren Steroidinjektion auf die\n Dupuytren-Progression im Fr\u00fchstadium: ein vorl\u00e4ufiger Bericht"],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":14,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,6,10]]},"published-print":{"date-parts":[[2026,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2760-7447","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0722-1819","1439-3980"],"issn-type":[{"value":"0722-1819","type":"print"},{"value":"1439-3980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]}}}