{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:55:28Z","timestamp":1785884128410,"version":"3.56.0"},"reference-count":92,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Colon Rectal Surg"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The management of locally advanced rectal cancer has evolved significantly with the introduction of total neoadjuvant therapy, which increases rates of clinical complete response and enables select patients to pursue non-operative management through a watch-and-wait strategy. While total mesorectal excision remains the standard curative approach, it is associated with considerable morbidity and long-term impacts on bowel, urinary, and sexual function. In contrast, non-operative management offers organ preservation and improved functional outcomes but carries oncologic uncertainty and requires intensive surveillance. This review examines the comparative benefits and limitations of total mesorectal excision and non-operative management, highlighting their impact on quality of life, recurrence risk, and patient-centered care. It also explores emerging strategies to support shared decision-making, including decision aids and predictive modeling, including risk preference assessments. These tools are essential to support informed, individualized decisions and to promote ethically grounded, evidence-based care in the evolving landscape of rectal cancer management.<\/jats:p>","DOI":"10.1055\/a-2760-7712","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:04:56Z","timestamp":1766534696000},"page":"389-396","source":"Crossref","is-referenced-by-count":0,"title":["Navigating Shared Decision-Making in Non-Operative Management of Locally Advanced Rectal Cancer"],"prefix":"10.1055","volume":"39","author":[{"given":"Racquel S.","family":"Gaetani","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery, Lahey Hospital and Medical Center, Burlington, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Abelson","sequence":"additional","affiliation":[{"name":"Department of Colon and Rectal Surgery, Lahey Hospital and Medical Center, Burlington, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.3390\/cancers16162807","article-title":"Journey through the decades: The evolution in treatment and shared decision making for locally advanced rectal cancer","volume":"16","author":"R S Gaetani","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.6004\/jnccn.2018.7032","article-title":"Evolving treatment paradigm in the treatment of locally advanced rectal cancer","volume":"16","author":"C A Smith","year":"2018","journal-title":"J Natl Compr Canc Netw"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJMoa010580","article-title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal 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Pennings","year":"2021","journal-title":"Colorectal Dis"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.ejso.2014.03.019","article-title":"Anastomotic leakage and presacral abscess formation after locally advanced rectal cancer surgery: Incidence, risk factors and treatment","volume":"40","author":"T A Vermeer","year":"2014","journal-title":"Eur J Surg Oncol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jss.2018.05.009","article-title":"Frequency and timing of short-term complications following abdominoperineal resection","volume":"231","author":"J E Tooley","year":"2018","journal-title":"J Surg Res"},{"issue":"05","key":"ref32","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/SLA.0b013e3181dae4ed","article-title":"Postoperative complications following surgery for rectal cancer","volume":"251","author":"B C Paun","year":"2010","journal-title":"Ann 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Surg"},{"issue":"09","key":"ref38","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/codi.14684","article-title":"Quality of life with or without sphincter preservation for rectal cancer","volume":"21","author":"M L Feddern","year":"2019","journal-title":"Colorectal Dis"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/DCR.0000000000001228","article-title":"Low anterior resection syndrome and quality of life after sphincter-sparing rectal cancer surgery: A long-term longitudinal follow-up","volume":"62","author":"E HA Pieniowski","year":"2019","journal-title":"Dis Colon Rectum"},{"issue":"05","key":"ref40","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1097\/SLA.0000000000002429","article-title":"Anastomotic leakage and chronic presacral sinus formation after low anterior resection: Results from a large cross-sectional study","volume":"266","author":"W AA Borstlap","year":"2017","journal-title":"Ann Surg"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.ejso.2012.07.111","article-title":"Meta-analysis of the risk for anastomotic leakage, the postoperative mortality caused by leakage in relation to the overall postoperative mortality","volume":"38","author":"H S Snijders","year":"2012","journal-title":"Eur J Surg Oncol"},{"issue":"04","key":"ref42","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.surg.2016.09.037","article-title":"Bowel dysfunction after anastomotic leakage in laparoscopic sphincter-saving operative intervention for rectal cancer: A case-matched study in 46 patients using the Low Anterior Resection Score","volume":"161","author":"E Hain","year":"2017","journal-title":"Surgery"},{"issue":"03","key":"ref43","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/DCR.0b013e318277e8a5","article-title":"Consequences of anastomotic leak after restorative proctectomy for cancer: Effect on long-term 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Colorectal Dis"},{"issue":"11","key":"ref53","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00384-015-2328-1","article-title":"Persistent perineal morbidity is common following abdominoperineal excision for rectal cancer","volume":"30","author":"D Asplund","year":"2015","journal-title":"Int J Colorectal Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/DCR.0000000000003710","article-title":"Persistent sitting and walking difficulties after abdominoperineal excision and anterior resection: Results from the Quality of Life in Rectal Cancer (QoLiRECT) Study","volume":"68","author":"L Bj\u00f6rklund Sand","year":"2025","journal-title":"Dis Colon Rectum"},{"issue":"09","key":"ref55","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/DCR.0000000000000639","article-title":"Wound complications and perineal pain after extralevator versus standard abdominoperineal excision: A nationwide study","volume":"59","author":"E P Colov","year":"2016","journal-title":"Dis Colon Rectum"},{"issue":"08","key":"ref56","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/ejso.2000.0998","article-title":"A prospective study on radical and nerve-preserving surgery for rectal cancer in the Netherlands","volume":"26","author":"C P Maas","year":"2000","journal-title":"Eur J Surg Oncol"},{"issue":"02","key":"ref57","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1046\/j.1365-2168.2000.01357.x","article-title":"Bladder and sexual dysfunction after mesorectal excision for rectal cancer","volume":"87","author":"A Nesbakken","year":"2000","journal-title":"Br J Surg"},{"issue":"09","key":"ref58","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.ejca.2008.12.014","article-title":"Risk factors for sexual dysfunction after rectal cancer treatment","volume":"45","author":"M M Lange","year":"2009","journal-title":"Eur J 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Thy\u00f8","year":"2019","journal-title":"Colorectal Dis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.radonc.2018.11.017","article-title":"Impact of radiotherapy on anorectal function in patients with rectal cancer following a watch and wait programme","volume":"132","author":"M E van der Sande","year":"2019","journal-title":"Radiother Oncol"},{"issue":"09","key":"ref66","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.ejso.2007.03.027","article-title":"Long-term urinary dysfunction after mesorectal excision: A prospective study with intraoperative electrophysiological confirmation of nerve preservation","volume":"33","author":"W Kneist","year":"2007","journal-title":"Eur J Surg Oncol"},{"issue":"06","key":"ref67","first-page":"428","article-title":"American Cancer Society Colorectal Cancer Survivorship Care Guidelines","volume":"65","author":"K El-Shami","year":"2015","journal-title":"CA Cancer J 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