{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T23:33:46Z","timestamp":1777073626576,"version":"3.51.4"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Im Januar 2020 wurde Coxiella (C.) burnetii in einem kleinen Ziegenbestand nachgewiesen, nachdem ein Abort, ein lebensschwaches und ein missgebildetes Kitz beobachtet worden waren.<\/jats:p>\n                  <jats:p>Alle Tiere ab einem Alter von 3 Monaten wurden bis Mai 2020 mit Coxevac grundimmunisiert (2x im Abstand von 3 Wochen) und im Herbst 2020 und im Mai 2021 revakziniert. Die Jungtiere wurden mit Ausnahme von 2023 j\u00e4hrlich grundimmunisiert. Die \u00dcberwachung erfolgte mit der qPCR-Untersuchung von Milchproben, Vaginal- und Pr\u00e4putial- (Genitaltupfer, GT), Nasen- (NT) und Umgebungstupfern (UT). Blut- und Milchproben wurden auf Phasen-(PhI, PhII)-spezifische Antik\u00f6rper untersucht, um die Impfung zu kontrollieren. Daten von einer geimpften, seronegativen Herde wurden f\u00fcr Vergleichszwecke herangezogen.<\/jats:p>\n                  <jats:p>Die Erregerlast in allen Probentypen sank bis Juni 2020 kontinuierlich ab. Schwach positive Proben wurden bis November (Milch), Dezember (GT) nachgewiesen. Zwei NT waren im Mai und Dezember 2021 schwach positiv (5 C.b.\/NT). Die Nachweisraten in UT waren bis April 2020 hoch (24\/24), sie verhielten sich \u00fcber den weiteren Verlauf des Jahres konstant (31\/40) und fielen erst in den Folgejahren sehr langsam ab: 12\/24 (2021), 5\/16 (2022), 2\/8 (2023), 1\/8 (2024) und 0\/8 (2025). Es wurden keine persistent-infizierten Ziegen ermittelt.<\/jats:p>\n                  <jats:p>Unerwartet f\u00fchrte die Impfung der Altziegen zu einem signifikanten Anstieg der PhI-Titer, die PhII-Titer ver\u00e4nderten sich jedoch nicht. Im Gegensatz hierzu f\u00fchrte die Impfung von seronegativen Jungziegen in der Fall- und Altziegen in der Kontrollherde zu einem signifikanten Anstieg der PhII-Titer, w\u00e4hrend PhI-Antik\u00f6rper kaum beobachtet wurden.<\/jats:p>\n                  <jats:p>Die Impfung f\u00fchrte zu keiner kurzfristigen Kontrolle der Erregerausscheidung, daher ist die prophylaktische Impfung sehr wichtig. Umgebungsproben erfordern eine quantitative Bewertung, sie sind langfristig f\u00fcr die \u00dcberwachung freier Best\u00e4nde wertvoll. Positive Ergebnisse der Umgebungsproben sollten mit NT oder GT \u00fcberpr\u00fcft werden. Genital- und NT sind gleichwertig, NT sind aber einfacher zu entnehmen.<\/jats:p>","DOI":"10.1055\/a-2762-6316","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T22:33:58Z","timestamp":1777070038000},"page":"124-134","source":"Crossref","is-referenced-by-count":0,"title":["Langfristige Verlaufskontrolle nach einem Coxiellose-Ausbruch in einem Ziegenbestand"],"prefix":"10.1055","volume":"54","author":[{"given":"Jens","family":"B\u00f6ttcher","sequence":"additional","affiliation":[{"name":"Tiergesundheitsdienst Bayern e.V."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britta","family":"Janowetz","sequence":"additional","affiliation":[{"name":"Tiergesundheitsdienst Bayern e.V."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Alex","sequence":"additional","affiliation":[{"name":"Tiergesundheitsdienst Bayern e.V."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Ambros","sequence":"additional","affiliation":[{"name":"Tiergesundheitsdienst Bayern e.V."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Domes","sequence":"additional","affiliation":[{"name":"Tiergesundheitsdienst Bayern e.V."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.2376\/0005-9366-19030","article-title":"Coxiella burnetii: A review focussing on infections in German sheep and goat flocks","volume":"113","author":"B U Bauer","year":"2020","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.medmal.2014.02.006","article-title":"Q fever in the Netherlands \u2013 2007\u20132010: what we learned from the largest outbreak 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