{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:42:37Z","timestamp":1792449757498,"version":"4.5.0"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The SARS-CoV-2-pandemic changed considerably over the course of time in terms of severity and mortality due to the impact of several SARS-CoV-2 variants as well as vaccination and preventive or SARS-CoV-2 specific therapies. We compared patients in two defined periods and analyzed the specific impact of pneumonia, including measures for treatment of respiratory failure.<\/jats:p>\n                  <jats:p>This was a single-center retrospective study of patients hospitalized with PCR-confirmed\n        and symptomatic SARS-CoV-2-infection in our center. The pandemic periods 3\/2020\u201312\/2021 and\n        1\/2022\u20133\/2023 as well as the periods after establishment of vaccination, preventive and\n        SARS-CoV-2-specific treatments 3\/2020\u20139\/2021 and 10\/2021\u20133\/2023 were compared.<\/jats:p>\n                  <jats:p>Overall, n=622 patients were included (n=307 in the first and n=315 in the second pandemic period). Marked differences were found with regard to age, severity of disease and pneumonia, interventions and mortality. Mortality of pneumonia was 25% (27% in the first and 20% in the second pandemic period); 40% of patients (36% patients with pneumonia) who died had not been admitted previously to the ICU. Mortality from pneumonia after exclusion of these patients was 18% (21% in the first and 10% in the second period). Mortality was particularly high in intubated patients with mechanical ventilation (67%).<\/jats:p>\n                  <jats:p>Our results were comparable with those reported in a national survey and another single center report of a nearby hospital. Treatment restrictions were frequently applied. Risk factors, severity and mortality of SARS-CoV-2-associated pneumonia in the second pandemic period were similar to those reported for community-acquired pneumonia. Excess mortality from mechanical ventilation deserves further investigation.<\/jats:p>","DOI":"10.1055\/a-2762-7934","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:26:50Z","timestamp":1790080010000},"page":"698-711","source":"Crossref","is-referenced-by-count":0,"title":["Pandemic revisited: Characteristics, severity and clinical outcomes of patients hospitalized with SARS-CoV-2-infection in different periods of the pandemic"],"prefix":"10.1055","volume":"80","author":[{"given":"Saliha","family":"Yagmur","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Bochum"],"department":["Kliniken f\u00fcr Pneumologie und Infektiologie, EVK Herne und Augusta-Krankenhaus Bochum"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Sabelhaus","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Germany","place":["Bochum"],"department":["Kliniken f\u00fcr Pneumologie und Infektiologie, EVK Herne und Augusta-Krankenhaus Bochum"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Florian","family":"Heuer","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, NRW, Germany","place":["Bochum"],"department":["Anesthesiology, Intensive Care Medicine, EVK Herne und Augusta-Krankenhaus Bochum"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ewig","sequence":"additional","affiliation":[{"name":"Thoraxzentrum Ruhrgebiet, Nordrhein-Westfalen, Germany","place":["Bochum"],"department":["Kliniken f\u00fcr Pneumologie und Infektiologie, EVK Herne und Augusta-Krankenhaus Bochum"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"China Medical Treatment Expert Group for Covid-19. 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Results from a nationwide mandatory performance measurement programme in healthcare quality","volume":"64","author":"S Ewig","year":"2009","journal-title":"Thorax"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1136\/thx.2009.129502","article-title":"Clinical and economic burden of community-acquired pneumonia among adults in Europe","volume":"67","author":"T Welte","year":"2012","journal-title":"Thorax"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/ije\/dyad012","article-title":"Characteristics and outcomes of an international cohort of 600\u200a000 hospitalized patients with COVID-19","volume":"52","author":"C Kartsonaki","year":"2023","journal-title":"Int J Epidemiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"m3339","DOI":"10.1136\/bmj.m3339","article-title":"Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score","volume":"370","author":"SR Knight","year":"2020","journal-title":"BMJ"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S2213-2600(20)30316-7","article-title":"Case characteristics, resource use, and outcomes of 10\u2008021 patients with COVID-19 admitted to 920 German hospitals: an observational study","volume":"8","author":"C Karagiannidis","year":"2020","journal-title":"Lancet Respir Med"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1055\/a-2235-0214","article-title":"Vergleich hospitalisierter Patienten mit SARS-CoV-2-Infektion in zwei Phasen der Pandemie [Comparison of hospitalized patients with SARS-CoV-2 infection in two time periods of the pandemic]","volume":"78","author":"JE Strehl","year":"2024","journal-title":"Pneumologie"},{"key":"ref17","first-page":"337","article-title":"Position paper for the state of the art application of respiratory support in patients with COVID-19 \u2013 German Respiratory Society","volume":"74","author":"M Pfeifer","year":"2020","journal-title":"Pneumologie"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00026-2021","article-title":"Conservative management of COVID 19-associated hypoxaemia","volume":"7","author":"T Voshaar","year":"2021","journal-title":"ERJ Open Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S2213-2600(24)00369-2","article-title":"In-hospital outcomes and 6-month follow-up results of patients supported with extracorporeal membrane oxygenation for COVID-19 from the second wave to the end of the pandemic (EuroECMO-COVID): a prospective, international, multicentre, observational study","volume":"13","author":"ME De Piero","year":"2025","journal-title":"Lancet Respir Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.rmed.2016.10.015","article-title":"Burden and risk factors of ambulatory or hospitalized CAP: A population based cohort study","volume":"121","author":"M Kolditz","year":"2016","journal-title":"Respir Med"}],"container-title":["Pneumologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2762-7934.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:38:52Z","timestamp":1792449532000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2762-7934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":19,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,19]]},"published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2762-7934","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0934-8387","1438-8790"],"issn-type":[{"value":"0934-8387","type":"print"},{"value":"1438-8790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]}}}