{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:08:52Z","timestamp":1789600132184,"version":"build-2803163510"},"reference-count":120,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Orthostatic tremor (OT) is a rare movement disorder characterized by high-frequency (13\u201318\u2009Hz) tremor in the legs and trunk during standing and relieved by sitting or walking. While OT is frequently an isolated disorder, some patients may have comorbid neurological conditions, such as essential tremor and parkinsonism, the so-called OT Plus. The pathophysiology of OT is not well-understood, and a specific central oscillator remains elusive, but current evidence suggests that ascending spinocerebellar and proprioceptive inputs, cerebellar processing, cerebello\u2013thalamo\u2013cortical signals, and cortico\u2013muscular coupling play a role in the pathophysiology of OT, suggesting that this is a network disorder. The treatment of OT is challenging, but pharmacological therapy includes gabapentin, clonazepam, perampanel, and levodopa. While spinal cord stimulation seems promising for selected patients, deep brain stimulation is mainly employed in severe cases, resulting in modest improvement in standing tolerance.<\/jats:p>","DOI":"10.1055\/a-2762-9483","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T23:54:45Z","timestamp":1764892485000},"page":"475-484","source":"Crossref","is-referenced-by-count":0,"title":["Orthostatic Tremor"],"prefix":"10.1055","volume":"46","author":[{"given":"Jos\u00e9 Fidel","family":"Baizabal-Carvallo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas, United States"},{"name":"Department of Sciences and Engineering, University of Guanajuato, Le\u00f3n, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"684835","DOI":"10.3389\/fneur.2021.684835","article-title":"Tremor syndromes: An updated review","volume":"12","author":"A Lenka","year":"2021","journal-title":"Front Neurol"},{"issue":"02","key":"ref2","first-page":"450","article-title":"On an unusual disorder of erect standing position (observation of 3 cases)","volume":"94","author":"P Pazzaglia","year":"1970","journal-title":"Riv Sper Freniatr Med Leg Alien Ment"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/mdc3.12127","article-title":"\u201cA disorder which occurs on standing\u201d: The earliest account of orthostatic tremor by Pazzaglia","volume":"2","author":"R 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