{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:47:44Z","timestamp":1790650064697,"version":"4.1.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Injectable collagen stimulators have traditionally been linked to inflammatory foreign-body reactions (FBR) as a mechanism of action. However, the next-generation PLLA-LASYNPRO microspheres, contained in the CE-marked JUL\u00c4INE medical device, may represent a paradigm shift. Preclinical data suggest these microspheres can promote collagen and extracellular matrix (ECM) regeneration with minimal inflammatory response.<\/jats:p>\n                  <jats:p>This study aimed to evaluate the scientific soundness and clinical relevance of a non-inflammatory mechanism of action for PLLA-LASYNPRO. The central hypothesis was that design and manufacturing innovations could enable effective biostimulation while reducing inflammation and long-term tissue reactions.<\/jats:p>\n                  <jats:p>A structured expert board meeting was convened to assess the rationale and implications of this emerging mechanism. The process included a preliminary survey and an in-person consensus meeting involving multidisciplinary specialists in aesthetic and regenerative medicine.<\/jats:p>\n                  <jats:p>On January 24, 2025, 13 experts in aesthetic medicine, dermatology, and plastic surgery participated in a board meeting held in Milan, Italy. Scientific literature and preclinical data were reviewed in advance. Discussions were organized around biophysical characteristics, tissue integration, inflammatory profile, and safety considerations.<\/jats:p>\n                  <jats:p>The board considered the non-inflammatory mechanism of PLLA-LASYNPRO both biologically plausible and clinically promising. Key differentiating features included particle morphology, lack of excipients, and manufacturing purity. The panel highlighted the potential to reduce chronic inflammation, a known limitation of traditional collagen stimulators. Early clinical impressions supported this hypothesis, although prospective data are still forthcoming.<\/jats:p>\n                  <jats:p>This manuscript presents the consensus of a multidisciplinary board on the rationale for PLLA-LASYNPRO in aesthetic and regenerative medicine. It forms the first part of a two-paper series. The second manuscript will provide practical clinical guidance for the deep dermal administration of PLLA-LASYNPRO and real-world use of JUL\u00c4INE.<\/jats:p>","DOI":"10.1055\/a-2764-3062","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:43:41Z","timestamp":1772243021000},"page":"538-544","source":"Crossref","is-referenced-by-count":2,"title":["First Insights on the Upcoming Role of Next-Generation PLLA-LASYNPRO in Aesthetic and Regenerative Medicine: A Survey of Experts\u2014the PLLA-LASYNPRO Rationale"],"prefix":"10.1055","volume":"42","author":[{"given":"Dario","family":"Bertossi","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Section of Oral and Maxillofacial Surgery, University of Verona, Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cavallini","sequence":"additional","affiliation":[{"name":"Executive Committee of Agor\u00e0, Italian Society of Aesthetic Medicine, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Camporese","sequence":"additional","affiliation":[{"name":"International School of Aesthetic Medicine, Fondazione Internazionale Fatebenefratelli, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Dell'Avanzato","sequence":"additional","affiliation":[{"name":"Private Practice, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Kefalas","sequence":"additional","affiliation":[{"name":"Rigenera Lab, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Massidda","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Niccol\u00f2 Cusano, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Papagni","sequence":"additional","affiliation":[{"name":"Executive Committee of Agor\u00e0, Italian Society of Aesthetic Medicine, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariagrazia","family":"Patalano","sequence":"additional","affiliation":[{"name":"Private Practice, Studio Mariagrazia Patalano, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Quartucci","sequence":"additional","affiliation":[{"name":"Saba Clinic, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Renga","sequence":"additional","affiliation":[{"name":"Executive Committee of Agor\u00e0, Italian Society of Aesthetic Medicine, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Santorelli","sequence":"additional","affiliation":[{"name":"Adriano Santorelli & Partners Private Practice, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-7068","authenticated-orcid":false,"given":"Chantal","family":"Sciuto","sequence":"additional","affiliation":[{"name":"Executive Committee of Agor\u00e0, Italian Society of Aesthetic Medicine, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Trocchi","sequence":"additional","affiliation":[{"name":"Pathology Isola Tiberina Hospital - Gemelli Isola, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.2310\/6350.2005.31236","article-title":"Facial volumetric correction with injectable poly-L-lactic acid","volume":"31","author":"D Vleggaar","year":"2005","journal-title":"Dermatol Surg"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2025040266","DOI":"10.20944\/preprints202504.0266.v1","article-title":"First insights on the upcoming role of next-generation PLLA-LASYNPRO\u2122 in aesthetic and regenerative medicine. 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