{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:47:37Z","timestamp":1782172057281,"version":"3.54.5"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lung cancer has a high recurrence rate after successful surgical treatment. This study deals with possible risk factors and recommendations to improve the treatment of non-small cell lung cancer (NSCLC).<\/jats:p>\n                  <jats:p>In this retrospective analysis, we used data of all NSCLC patients who underwent lobectomy at the Lung Cancer Center Munich between 2011 and 2020. Only patients with postoperative T1\u20134, N0, R0, M0 were included. We compared numerical outcomes between patients with distant, lymph node, local recurrence and no recurrence using analysis of variance (ANOVA), and categorical outcomes using Chi-squared test or Fisher\u2019s exact test when cell numbers were &lt;6. We used logistic regression models to identify factors significantly associated with the occurrence of a distant, lymph node and local recurrence.<\/jats:p>\n                  <jats:p>Tumor size in cm was significantly higher in patients with local recurrence (mean 5.5) followed by distant recurrence (mean 4.0), lymph node recurrence (mean 3.1) and patients with no recurrence (mean 3.0), p&lt;0.0001. Diffusing capacity for carbon monoxide (DLCO) in % was significantly higher in patients with no recurrence (72.9) and decreased with distant recurrence (67.0), local recurrence (66.7) and lymph node recurrence (65.8), p=0.01. There were no significant differences in postoperative complications, surgical approach or number of lymph node assessed. A tumor size \u22654.65\u2009cm was identified as an independent marker for local recurrence.<\/jats:p>\n                  <jats:p>For patients with NSCLC \u22654.65 cm, which corresponds to UICC stage IIA and higher, multimodal therapy should be discussed. The surgical approach has no influence on recurrence.<\/jats:p>","DOI":"10.1055\/a-2766-4308","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:09:37Z","timestamp":1769126977000},"page":"426-437","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of distant, local and lymph node recurrence for surgically treated non-small cell lung cancer (NSCLC) patients: Retrospective analysis of pathological T1\u20134, N0, R0, M0 tumor stages"],"prefix":"10.1055","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9806-3397","authenticated-orcid":false,"given":"Julia","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany","place":["Munich"],"department":["Thoracic Surgery"]},{"name":"Asklepios Fachkliniken M\u00fcnchen-Gauting, BY, Germany","place":["Gauting"],"department":["Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Walter","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany","place":["Munich"],"department":["Internal Medicine V"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Samm","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany","place":["Munich"],"department":["Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6kce","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany","place":["Munich"],"department":["Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ketscher","sequence":"additional","affiliation":[{"name":"Asklepios Fachkliniken M\u00fcnchen-Gauting, BY, Germany","place":["Gauting"],"department":["Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Reinmuth","sequence":"additional","affiliation":[{"name":"Asklepios Fachkliniken M\u00fcnchen-Gauting, Germany","place":["Gauting"],"department":["Thoracic Oncology"]},{"name":"Helmholtz Zentrum M\u00fcnchen Institut f\u00fcr Molekulare Immunologie, BY, Germany","place":["Munich"],"department":["Institute for Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Merk","sequence":"additional","affiliation":[{"name":"Asklepios Fachkliniken M\u00fcnchen-Gauting, Germany","place":["Gauting"],"department":["Thoracic Oncology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Hatz","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany","place":["Munich"],"department":["Thoracic Surgery"]},{"name":"Helmholtz Zentrum M\u00fcnchen Institut f\u00fcr Molekulare Immunologie, BY, Germany","place":["Munich"],"department":["Institute for Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive"]},{"name":"Asklepios Fachkliniken M\u00fcnchen-Gauting, BY, Germany","place":["Gauting"],"department":["Thoracic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Tufman","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany","place":["Munich"],"department":["Internal Medicine V"]},{"name":"Helmholtz Zentrum M\u00fcnchen Institut f\u00fcr Molekulare Immunologie, BY, Germany","place":["Munich"],"department":["Institute for Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, Germany","place":["Munich"],"department":["Thoracic Surgery"]},{"name":"Helmholtz Zentrum M\u00fcnchen Institut f\u00fcr Molekulare Immunologie, BY, Germany","place":["Munich"],"department":["Institute for Lung Health and Immunity and Comprehensive Pneumology Center with the CPC-M bioArchive"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e278S","DOI":"10.1378\/chest.12-2359","article-title":"Treatment of stage I and II 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