{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:12:19Z","timestamp":1771035139208,"version":"3.50.1"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to investigate accidental secondary pentobarbital intoxications in domestic and wild animals in Europe.<\/jats:p>\n                  <jats:p>Case reports of accidental secondary pentobarbital intoxication were searched for in 2 veterinary pharmacovigilance databases (VigilanceVET and EudraVigilance Veterinary). In addition, 2 toxicology laboratories were asked for information concerning pentobarbital intoxications in animals.<\/jats:p>\n                  <jats:p>Overall, reports were found for 178 animals affected by secondary pentobarbital intoxication including 109 domestic animals (2 cats, 107 dogs) and 69 wild birds. The source of accidental secondary exposure was identified in all cases involving domestic animals and included various ingested organic materials, such as blood, tissue, and whole carcasses of farm and pet animals. The most frequently reported clinical signs in dogs were neurological disorders, such as ataxia, disturbances of consciousness, or convulsions, and systemic disorders, such as lethargy, recumbency, hypothermia, and even death in 9 dogs. In total, 34 cases involving 69 wild birds were identified. Of these 69 wild birds 57 died. The material that caused the intoxication was reported in only 5 cases and included tissue from farm animals and pets. A detailed medical history was available for one case involving a wild common buzzard (Buteo buteo) that had survived exposure to pentobarbital.<\/jats:p>\n                  <jats:p>Ingestion of tissue or blood from euthanised animals may lead to pentobarbital intoxication in domestic and wild animals, which may remain undiscovered due to non-specific clinical signs. Screening for pentobarbital should be considered in free-roaming dogs and cats presenting with neurological signs, as well as in carnivorous or scavenging wildlife exhibiting unclear neurological symptoms or dying from unknown causes.<\/jats:p>","DOI":"10.1055\/a-2768-0972","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:45:33Z","timestamp":1771033533000},"page":"23-31","source":"Crossref","is-referenced-by-count":0,"title":["Accidental secondary pentobarbital intoxication in small domestic animals and wild birds in Europe"],"prefix":"10.1055","volume":"54","author":[{"given":"Ann","family":"Neubert","sequence":"additional","affiliation":[{"name":"Bundesamt f\u00fcr Verbraucherschutz und Lebensmittelsicherheit (BVL), Abteilung 3 Tierarzneimittel, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Schnurr","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmakologie, Toxikologie und Pharmazie, Tier\u00e4rztliche Fakult\u00e4t, LMU M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Ammer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Pharmakologie, Toxikologie und Pharmazie, Tier\u00e4rztliche Fakult\u00e4t, LMU M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Krone","sequence":"additional","affiliation":[{"name":"Leibniz-Institut f\u00fcr Zoo- und Wildtierforschung, Abteilung Wildtierkrankheiten, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Scholtis","sequence":"additional","affiliation":[{"name":"Landesinstitut f\u00fcr gerichtliche und soziale Medizin Berlin, Abteilung Forensische Toxikologie, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance","family":"McDaniel","sequence":"additional","affiliation":[{"name":"Bundesamt f\u00fcr Verbraucherschutz und Lebensmittelsicherheit (BVL), Abteilung 3 Tierarzneimittel, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Klein- und Heimtierklinik, Abteilung Kleins\u00e4uger, V\u00f6gel, Reptilien, Freie Universit\u00e4t Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/epi.12025","article-title":"How theories evolved concerning the mechanism of action of barbiturates","volume":"53","author":"W Loscher","year":"2012","journal-title":"Epilepsia."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"117452","DOI":"10.1016\/j.envpol.2021.117452","article-title":"Increasing incidence of barbiturate intoxication in avian scavengers and mammals in Spain","volume":"284","author":"M Herrero-Villar","year":"2021","journal-title":"Environ Pollut"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1177\/0300985816641176","article-title":"Integrating the forensic sciences in wildlife case investigations: a case report of pentobarbital and phenytoin toxicosis in a bald eagle (Haliaeetus leucocephalus)","volume":"53","author":"T C Viner","year":"2016","journal-title":"Vet Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2885.2007.00836.x","article-title":"Pesticides and the intoxication of wild animals","volume":"30","author":"P Berny","year":"2007","journal-title":"J Vet Pharmacol Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e000224","DOI":"10.1136\/vetreco-2017-000224","article-title":"Veterinary pharmacovigilance in Europe: a survey of veterinary practitioners","volume":"4","author":"N De Briyne","year":"2017","journal-title":"Vet Rec Open"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2460\/javma.23.03.0161","article-title":"Survey of veterinarians who use pentobarbital for euthanasia suggests knowledge gaps regarding animal disposal","volume":"261","author":"W Hess","year":"2023","journal-title":"Javma-J Am Vet Med A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1007\/s11259-023-10093-2","article-title":"Pentobarbital intoxication as a potential underlying cause for electrocution in a bearded vulture","volume":"47","author":"M Herrero-Villar","year":"2023","journal-title":"Vet Res Commun"},{"key":"ref13","first-page":"619","volume-title":"Pentobarbital Sodium. In: Papich MG, editor. Saunders Handbook of Veterinary Drugs (Fourth Edition).","author":"M G Papich","year":"2016"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2460\/javma.1998.213.02.240","article-title":"Comparison of five regimens for oral administration of medication to induce sedation in dogs prior to euthanasia","volume":"213","author":"E C Ramsay","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0379-0738(02)00420-6","article-title":"Suicide by injection of a veterinarian barbiturate euthanasia agent: report of a case and toxicological analysis","volume":"131","author":"N Romain","year":"2003","journal-title":"Forensic Sci Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0379-0738(01)00483-2","article-title":"Drug and chemical blood-level data 2001","volume":"122","author":"C L Winek","year":"2001","journal-title":"Forensic Sci 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O&Connor","year":"1985","journal-title":"Am J Vet Res"},{"key":"ref21","first-page":"118","article-title":"Relay pentobarbitone toxicosis in an American Bulldog","volume":"45","author":"J B King","year":"2015","journal-title":"Aust Vet J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1177\/104063871002200423","article-title":"Secondary pentobarbital poisoning in two dogs: a cautionary tale","volume":"22","author":"A M Kaiser","year":"2010","journal-title":"J Vet Diagn Invest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"104000","DOI":"10.1016\/j.jevs.2022.104000","article-title":"Characteristics and sodium pentobarbital concentrations of equine mortality compost piles in the Upper Midwest","volume":"114","author":"H L Lochner","year":"2022","journal-title":"J Equine Vet Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijscr.2020.05.032","article-title":"Pentobarbital induced hypokalemia: a worrying sequela","volume":"71","author":"M Awad","year":"2020","journal-title":"Int J Surg Case Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1081\/JLC-100102066","article-title":"Determination of pentobarbital in biological samples by micellar liquid chromatography","volume":"22","author":"Y Martin-Biosca","year":"1999","journal-title":"J Liq Chromatogr R T."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/10406387211070539","article-title":"Evaluation of a human urine barbiturate test to screen for pentobarbital euthanasia of dogs and cats","volume":"34","author":"A W Stern","year":"2022","journal-title":"J Vet Diagn Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1647\/21-00057","article-title":"Intralipid emulsion therapy for the treatment of suspected toxicity in 2 avian species","volume":"36","author":"L K Schmidt","year":"2023","journal-title":"J Avian Med Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3109\/08860229609052800","article-title":"Hemodiafiltration in pentobarbital poisoning","volume":"18","author":"E Bironneau","year":"1996","journal-title":"Ren Fail"},{"key":"ref30","first-page":"178","volume-title":"Use of continuous venovenous hemodiafiltration in a case of severe pentobarbital poisoning","author":"Y Nieto Pinar","year":"2023"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0195-5616(90)50035-2","article-title":"Illicit and abused drugs","volume":"20","author":"W C Kisseberth","year":"1990","journal-title":"Vet Clin N Am-Small"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/BF00295761","article-title":"Barbiturate poisoning and gastrointestinal propulsion","volume":"60","author":"P Holzer","year":"1987","journal-title":"Arch Toxicol"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2768-0972.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:45:40Z","timestamp":1771033540000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2768-0972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":26,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2026,2,11]]},"published-print":{"date-parts":[[2026,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2768-0972","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"value":"1434-1239","type":"print"},{"value":"2567-5842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}