{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:47:24Z","timestamp":1776898044438,"version":"3.51.2"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Hyperlipas\u00e4mien treten h\u00e4ufig bei Lebererkrankungen auf. Alkoholkonsum, Diabetes und Medikamente k\u00f6nnen die Lipasekonzentration im Blut beeinflussen. Ziel dieser Registerstudie war es, den Effekt von direkt wirkenden antiviralen Arzneimitteln (DAAs) auf die Frequenz von Hyperlipas\u00e4mien bei Patienten mit Hepatitis-C-Virus (HCV)-Infektion zu untersuchen. Weiterhin wurde Alkoholkonsum und die Diagnose eines Diabetes Mellitus als Einflussfaktor betrachtet.Lipasekonzentrationen von Patienten des Deutschen Hepatitis-C-Registers (2014\u20132022) wurden retrospektiv analysiert. Werte &lt;60 U\/l galten als normal. Hyperlipas\u00e4mien wurden in \u201emild\u201c, \u201emoderat\u201c und \u201eschwer\u201c eingeteilt. Patienten wurden anhand des Alkoholkonsums in \u201ekein\u201c, \u201eniedriger\u201c und \u201ehoher\u201c Alkoholkonsum oder dem Vorliegen eines Diabetes Mellitus kategorisiert.Vor DAA-Therapie zeigten 17,2% der Patienten erh\u00f6hte Lipasekonzentrationen. Posttherapeutisch sank die Frequenz an Hyperlipas\u00e4mien, mit einem Tiefstwert von 12,1% in Jahr 6 nach Therapie. Patienten mit geringem Alkoholkonsum wiesen die niedrigste Hyperlipas\u00e4mie-Rate auf. Diabetes war mit erh\u00f6hten Lipasekonzentrationen assoziiert. Schwere Hyperlipas\u00e4mien traten geh\u00e4uft am Therapieende auf, waren jedoch insgesamt selten und klinisch inapparent. \n               Fazit Hyperlipas\u00e4mien sind bei HCV-Infektion h\u00e4ufig. Starker Alkoholkonsum und Diabetes sind zus\u00e4tzliche Risikofaktoren f\u00fcr eine Hyperlipas\u00e4mie. Ein Einfluss der DAA-Therapie auf die Pr\u00e4valenz von Hyperlipas\u00e4mien ist m\u00f6glich. Weitere Einflussfaktoren einschlie\u00dflich Lebensstil, Medikamenteneinnahme oder Organdysfunktionen m\u00fcssen untersucht werden, um Kausalit\u00e4ten herzustellen. Die Messung der Lipasekonzentration im Blut ohne spezifischen klinischen Grund muss kritisch hinterfragt und die Interpretation stets im Gesamtkontext betrachtet werden.<\/jats:p>","DOI":"10.1055\/a-2769-3946","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:31:27Z","timestamp":1776897087000},"page":"346-352","source":"Crossref","is-referenced-by-count":0,"title":["Hyperlipas\u00e4mie nach Therapie mit direkt antiviralen Arzneimitteln bei Patienten mit chronischer Hepatitis-C-Virusinfektion \u2013 Daten aus dem Deutschen Hepatitis C-Register (DHC-R)"],"prefix":"10.1055","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-2462","authenticated-orcid":false,"given":"Bernd","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie, Infektiologie & Endokrinologie, Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Buggisch","sequence":"additional","affiliation":[{"name":"ifi-Institut f\u00fcr interdisziplin\u00e4re Medizin, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlinde","family":"Teuber","sequence":"additional","affiliation":[{"name":"Praxis PD Dr. med. 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Teuber, Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Stoehr","sequence":"additional","affiliation":[{"name":"ifi-Institut f\u00fcr interdisziplin\u00e4re Medizin, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Christensen","sequence":"additional","affiliation":[{"name":"Centrum f\u00fcr Infektiologie, M\u00fcnster, Germany"},{"name":"Klinik f\u00fcr Gastroenterologie und Hepatologie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Mauss","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr HIV und Hepatogastroenterologie, D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Sarrazin","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 2, St. Josefs-Hospital, Wiesbaden, Germany"},{"name":"Medizinische Klinik I, Universit\u00e4tsklinikum Frankfurt, Frankfurt am Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Berg","sequence":"additional","affiliation":[{"name":"Bereich Hepatologie, Medizinische Klinik II, Universit\u00e4tsklinikum Leipzig, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie, Medizinische Hochschule Hannover, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/hpb.12277","article-title":"Significant elevations of serum lipase not caused by pancreatitis: a systematic review","volume":"17","author":"AM 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