{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:36:00Z","timestamp":1768570560836,"version":"3.49.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Group B Streptococcus (GBS) is the leading cause of sepsis, pneumonia, and\/or meningitis in neonates. Insertion of an umbilical catheter (UC) is a common practice in neonatal intensive care for primary central vascular access in extreme premature neonates. UC is used for the administration of intravenous medications, parenteral nutrition, blood samplings, and continuous central blood pressure monitoring. Malposition or migration of UC tends to occur in extreme premature infants with risks of multiple complications. We present a case of an extreme premature neonate who developed fatal GBS sepsis with autopsy findings of multiple cardiac abscesses in the myocardium but not in any other organ. GBS sepsis with isolated multifocal myocardial abscesses leading to sudden fatal clinical deterioration has not been described previously. In this review, we describe the plausible pathological mechanism of this rare presentation. Intracardiac migrated UC, in conjunction with rhythmic heart contractions and intracardiac blood flow dynamics, can cause direct trauma to the endocardium. Damaged endocardium can be a potential nidus for bacterial overgrowth and abscess formation that ultimately may lead to cardiac failure. Therefore, the correct aseptic technique of securing and management of UC, and daily assessment of UC position are recommended to prevent complications associated with catheter migration.<\/jats:p>","DOI":"10.1055\/a-2770-5011","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:13:49Z","timestamp":1765584829000},"page":"e10-e17","source":"Crossref","is-referenced-by-count":0,"title":["Group B Streptococcus Sepsis with Cardiac Abscesses in a Neonate with Migrated Umbilical Catheter: Literature Review"],"prefix":"10.1055","volume":"16","author":[{"given":"Trenton","family":"Judd","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Tennessee Health Science Center, Regional One Health Hospital NICU, LeBonheur Children's Hospital NICU, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1864-5897","authenticated-orcid":false,"given":"Mimily","family":"Harsono","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Tennessee Health Science Center, Regional One Health Hospital NICU, LeBonheur Children's Hospital NICU, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Pathology, Department of Pathology, University of Tennessee Health Science Center, LeBonheur Children's Hospital, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Mir","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Tennessee Health Science Center, Regional One Health Hospital, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massroor","family":"Pourcyrous","sequence":"additional","affiliation":[{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Tennessee Health Science Center, Regional One Health Hospital NICU, LeBonheur Children's Hospital NICU, Memphis, Tennessee, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1542\/pir.2023-006154","article-title":"Neonatal Group B Streptococcus disease","volume":"45","author":"S A Coggins","year":"2024","journal-title":"Pediatr Rev"},{"key":"ref2","volume-title":"Group B streptococcal infections","author":"Committee on Infectious Diseases","year":"2024"},{"key":"ref3","first-page":"20","article-title":"Transmission of Group B Streptococcus in late-onset neonatal 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