{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:28:47Z","timestamp":1792445327829,"version":"4.5.0"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"crossref","award":["2022YFS0044"],"award-info":[{"award-number":["2022YFS0044"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neonatal acute peritonitis is a leading cause of morbidity and mortality and poses challenges that demand prompt diagnosis and treatment, particularly in infants with disseminated intravascular coagulation. Here, we report a case series of four infants with acute peritonitis caused by necrotizing enterocolitis, gastrointestinal perforation, and meconium peritonitis. Laboratory tests for thrombin\u2013antithrombin III complex (TAT), plasmin-\u03b12-plasmin inhibitor complex (PIC), soluble thrombomodulin (sTM), and tissue plasminogen activator\u2013inhibitor complex (t-PAIC) suggested the activation of the coagulation system followed by treatment with anticoagulant therapy in these infants. Overall, TAT, PIC, t-PAIC, and sTM may guide anticoagulant therapy, offering prospects for improving the outcomes in neonates with acute peritonitis.<\/jats:p>","DOI":"10.1055\/a-2770-6902","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:15:28Z","timestamp":1765844128000},"source":"Crossref","is-referenced-by-count":1,"special_numbering":"S","title":["Anticoagulant Therapy in Neonatal Acute Infectious Peritonitis Based on the TAT, PIC, t-PAIC, and sTM: A New Case Series"],"prefix":"10.1055","volume":"09","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6663-8244","authenticated-orcid":false,"given":"Wenya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China"},{"name":"Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China"},{"name":"Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shanxi Coal Central Hospital, Taiyuan, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China"},{"name":"Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-5708","authenticated-orcid":false,"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sichuan University West China Second University Hospital, Chengdu, Sichuan, China"},{"name":"Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000533825","article-title":"Hospital variation in mortality and failure to rescue after surgery for 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