{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:24:51Z","timestamp":1769516691100,"version":"3.49.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vitamin A is a fat-soluble micronutrient essential for normal embryonic\n                        development, cell differentiation, growth, vision, immunity and\n                        reproduction. The aim of this study was to evaluate the effect of vitamin A\n                        and retinol-binding protein levels in cord blood of babies born at or below\n                        the 31st gestational week on respiratory distress syndrome,\n                        intraventricular haemorrhage, necrotising enterocolitis, retinopathy of\n                        prematurity and bronchopulmonary dysplasia and mortality.<\/jats:p>\n                  <jats:p>Babies born between 25 0\/7 and 30 6\/7 gestational weeks were included in the\n                        study between January 2021 and December 2022. Blood samples were obtained\n                        from the cord blood for retinol and retinol-binding protein levels.<\/jats:p>\n                  <jats:p>Sixty preterm infants born between 25 0\/7 and 30 6\/7 gestational weeks were\n                        included in this study. The mean vitamin A level was 244\u00b1140 \u00b5g\/L and the\n                        mean retinol-binding protein level was 1.7\u00b10.4 mg\/dL. Among premature\n                        infants, 43% had low vitamin A levels and 38% had low retinol-binding\n                        protein levels. The retinol-binding protein level was found to be\n                        significantly lower in babies with retinopathy of prematurity compared with\n                        babies without retinopathy of prematurity (p&lt;0.05).<\/jats:p>\n                  <jats:p>In our study in which we investigated the effect of vitamin A and\n                        retinol-binding protein levels on morbidity and mortality in preterm\n                        infants, we showed that retinopathy of prematurity increased with low\n                        retinol-binding protein levels in cord blood. Further studies by evaluating\n                        the retinol-binding protein level together with the vitamin A level in the\n                        later days of life in response to vitamin A supplementation may more\n                        accurately show the effect of vitamin A on neonatal morbidities.<\/jats:p>","DOI":"10.1055\/a-2770-8001","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:07:30Z","timestamp":1769472450000},"source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Vitamin A and Retinol-Binding Protein Levels in Cord\n                    Blood of Very Low Birth Weight Infants on Mortality and\n                    Morbidity"],"prefix":"10.1055","author":[{"given":"Bet\u00fcl","family":"Siyah Bilgin","sequence":"additional","affiliation":[{"name":"Neonatology, Ministry of Health Ankara Bilkent City\n                    Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcls\u00fcm","family":"Kad\u0131o\u011flu \u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Neonatology, Ministry of Health Ankara Bilkent City\n                    Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6k\u00e7e","family":"\u00c7\u0131plak","sequence":"additional","affiliation":[{"name":"Neonatology, Ministry of Health Ankara Bilkent City\n                    Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayb\u00fcke","family":"Yaz\u0131c\u0131","sequence":"additional","affiliation":[{"name":"Neonatology, Ministry of Health Ankara Bilkent City\n                    Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-5591","authenticated-orcid":false,"given":"Sarkhan","family":"Elbayiyev","sequence":"additional","affiliation":[{"name":"Neonatology, Azerbaijan Medical University, Baku,\n                    Azerbaijan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayriye G\u00f6zde","family":"Kutman Kanmaz","sequence":"additional","affiliation":[{"name":"Neonatology, Ministry of Health Ankara Bilkent City\n                    Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuat Emre","family":"Canpolat","sequence":"additional","affiliation":[{"name":"Neonatology, Ministry of Health Ankara Bilkent City\n                    Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3390\/nu11030681","article-title":"Vitamin A and Pregnancy: A Narrative Review","volume":"11","author":"S Bastos Maia","year":"2019","journal-title":"Nutrients"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.earlhumdev.2005.01.007","article-title":"Reference range for micronutrients and nutritional marker proteins in cord blood\n                    of neonates appropriated for gestational ages","volume":"81","author":"A Galinier","year":"2005","journal-title":"Early Hum Dev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1093\/ajcn\/nqab294","article-title":"Vitamin A supplementation in very-preterm or very-low-birth-weight infants to\n                    prevent morbidity and mortality: a systematic review and meta-analysis of\n                    randomized trials","volume":"114","author":"A A Rakshasbhuvankar","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/s0378-3782(99)00032-8","article-title":"Cord blood concentrations of vitamin A in preterm infants","volume":"56","author":"O Tammela","year":"1999","journal-title":"Early Hum Dev"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/s0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage: a study\n                    of infants with birth weights less than 1,500 gm","volume":"92","author":"L A Papile","year":"1978","journal-title":"J Pediatr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. 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Zhang","year":"2022","journal-title":"Turk J Pediatr"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1159\/000518680","article-title":"Effect of Enteral Vitamin A on Fecal Calprotectin in Extremely Preterm Infants:\n                    A Nested Prospective Observational Study","volume":"118","author":"A A Rakshasbhuvankar","year":"2021","journal-title":"Neonatology"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.26355\/eurrev_202203_28344","article-title":"The relationship between Vitamin A and Vitamin E levels and neonatal\n                    morbidities","volume":"26","author":"I Deger","year":"2022","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e23101","DOI":"10.1097\/md.0000000000023101","article-title":"Vitamin A supplementation prevents the bronchopulmonary dysplasia in premature\n                    infants: A systematic review and 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