{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:41:50Z","timestamp":1791049310548,"version":"4.1.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No. 82071942"],"award-info":[{"award-number":["Grant No. 82071942"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To investigate the role of ultra-microangiography (UMA) in evaluating Crohn\u2019s disease (CD) activity in pediatric patients.<\/jats:p>\n                  <jats:p>Pediatric patients diagnosed with CD were included in this prospective study. A Resona A20 ultrasound machine (Mindray Medical Systems, China) was used for all patients. The semiquantitative scores of color Doppler flow imaging (CDFI) and UMA on the thickest segments of bowel walls were assessed according to the Limberg score. The Pediatric Crohn\u2019s Disease Activity Index (PCDAI) was the reference standard to evaluate CD activity. ROC analysis was performed to compare the diagnostic efficiency of Limberg scores between CDFI and UMA.<\/jats:p>\n                  <jats:p>Sixty pediatric CD patients were included and divided into three groups according to PCDAI: Group 1, inactive CD (n = 37); Group 2, mild CD (n = 13); and Group 3, moderate to severe CD (n = 10). By UMA, significant differences in Limberg scores were found between Groups 1 and 3 (P &lt; 0.001), Groups 2 and 3 (P = 0.044), and Groups 1 and 2 (P = 0.029). The combined AUROC of B-mode ultrasound (BMUS) features and UMA features in pediatric CD activity evaluation was 0.934, with sensitivity of 87.0% and specificity of 94.6%, which was significantly higher than that of the combined BMUS features and CDFI (P = 0.048).<\/jats:p>\n                  <jats:p>By sensitively depicting the low velocity blood flow signals and displaying microvascular morphologies of the bowel wall, UMA is an effective noninvasive imaging method enabling semiquantitative evaluation of the activity of CD in pediatric patients.<\/jats:p>","DOI":"10.1055\/a-2771-2690","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:15:25Z","timestamp":1765584925000},"source":"Crossref","is-referenced-by-count":2,"title":["Ultra-Microangiography for Evaluating Crohn\u2019s Disease Activity in Pediatric Patients: A Prospective Study"],"prefix":"10.1055","author":[{"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Feng","sequence":"first","affiliation":[{"name":"Pediatric Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-3304","authenticated-orcid":false,"given":"Yunlin","family":"Huang","sequence":"additional","affiliation":[{"name":"Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyang","family":"Guan","sequence":"additional","affiliation":[{"name":"Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassa","family":"Darge","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, United States"},{"name":"University of Pennsylvania Perelman School of Medicine, Philadelphia, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-1477","authenticated-orcid":false,"given":"Yi","family":"Dong","sequence":"additional","affiliation":[{"name":"Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41572-020-0156-2","article-title":"Crohn\u2019s disease","volume":"6","author":"G Roda","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1053\/j.gastro.2021.12.282","article-title":"Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review","volume":"162","author":"ME Kuenzig","year":"2022","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022-058037","article-title":"Pediatric Inflammatory Bowel Disease","volume":"151","author":"M Bouhuys","year":"2023","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1016\/S0140-6736(23)02586-2","article-title":"Crohn\u2019s disease","volume":"403","author":"M Dolinger","year":"2024","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD","volume":"160","author":"D Turner","year":"2021","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1093\/ecco-jcc\/jjac187","article-title":"ECCO Guidelines on Inflammatory Bowel Disease and Malignancies","volume":"17","author":"H Gordon","year":"2023","journal-title":"J Crohns Colitis"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1007\/s00247-020-04868-x","article-title":"Contrast-enhanced ultrasound of the pediatric bowel","volume":"51","author":"A Gokli","year":"2021","journal-title":"Pediatr Radiol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1055\/s-0043-125329","article-title":"EFSUMB Recommendations and Clinical Guidelines for Intestinal Ultrasound (GIUS) in Inflammatory Bowel Diseases","volume":"39","author":"G Maconi","year":"2018","journal-title":"Ultraschall Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s11894-023-00892-7","article-title":"Point-of-Care Intestinal Ultrasound in Pediatric Inflammatory Bowel Disease","volume":"25","author":"MT Dolinger","year":"2023","journal-title":"Curr Gastroenterol Rep"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"194","DOI":"10.15403\/jgld-5495","article-title":"High-resolution Visualization of Intestinal Microcirculation using Ultra-microangiography in Patients with Inflammatory Bowel Disease: A Pilot Study","volume":"33","author":"S Albaladejo-Fuertes","year":"2024","journal-title":"J Gastrointestin Liver Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1186\/s12885-025-14197-7","article-title":"Biomarkers of microvascularture by ultra Micro-angiography (UMA) assist to identify papillary thyroid carcinoma (PTC) with atypia of undetermined significance","volume":"25","author":"Q Wang","year":"2025","journal-title":"BMC Cancer"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.ultrasmedbio.2025.03.001","article-title":"Advancements in Noncontrast Ultrasound Imaging for Low-Velocity Flow: A Technical Review and Clinical Applications in Vascular Medicine","volume":"51","author":"R Seddiki","year":"2025","journal-title":"Ultrasound Med Biol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s10396-022-01236-0","article-title":"Basic practices for gastrointestinal ultrasound","volume":"50","author":"M Nishida","year":"2022","journal-title":"Journal of Medical Ultrasonics"},{"key":"ref14","first-page":"495","article-title":"Diagnosis of chronic inflammatory bowel disease by ultrasonography","volume":"37","author":"B Limberg","year":"1999","journal-title":"Z Gastroenterol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1097\/MPG.0000000000001227","article-title":"Which PCDAI Version Best Reflects Intestinal Inflammation in Pediatric Crohn Disease?","volume":"64","author":"D Turner","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1186\/s12885-023-11325-z","article-title":"Kappa statistic considerations in evaluating inter-rater reliability between two raters: which, when and context matters","volume":"23","author":"M Li","year":"2023","journal-title":"BMC Cancer"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1136\/gutjnl-2021-326562","article-title":"Recent advances in clinical practice: advances in cross-sectional imaging in inflammatory bowel disease","volume":"71","author":"J Rimola","year":"2022","journal-title":"Gut"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3390\/diagnostics14070672","article-title":"Application of Dynamic Contrast-Enhanced Ultrasound in Evaluation the Activity of Crohn\u2019s Disease","volume":"14","author":"Y Wang","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1159\/000078737","article-title":"Evaluation of criteria for the activity of Crohn\u2019s disease by power Doppler sonography","volume":"22","author":"H Neye","year":"2004","journal-title":"Dig Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s12664-020-01019-w","article-title":"Utility of bowel ultrasound in assessing disease activity in Crohn\u2019s disease","volume":"39","author":"P Kakkadasam Ramaswamy","year":"2020","journal-title":"Indian Journal of Gastroenterology"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109567","article-title":"Ultra-microangiography in evaluating the disease activity of rheumatoid arthritis and enhancing the efficacy of ultrasonography: A preliminary study","volume":"137","author":"C Zhao","year":"2021","journal-title":"Eur J Radiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"S1542","DOI":"10.1016\/j.cgh.2024.10.021","article-title":"Prevalence and Prognosis of Mild Inflammatory Bowel Disease: A Population-based Cohort Study, 1997\u20132020","volume":"13","author":"HA Jacobsen","year":"2024","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1148\/rg.2020200019","article-title":"Contrast-enhanced US in Pediatric Patients: Overview of Bowel Applications","volume":"40","author":"A Gokli","year":"2020","journal-title":"Radiographics"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.5217\/ir.2018.00124","article-title":"Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn\u2019s disease: comparison with magnetic resonance enterography","volume":"17","author":"AC da Silva Moraes","year":"2019","journal-title":"Intest Res"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1148\/radiol.213303","article-title":"Microvascular Flow Imaging: A State-of-the-Art Review of Clinical Use and Promise","volume":"305","author":"MU Aziz","year":"2022","journal-title":"Radiology"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1093\/ibd\/izy115","article-title":"Real-Time Shear Wave Ultrasound Elastography Differentiates Fibrotic from Inflammatory Strictures in Patients with Crohn\u2019s Disease","volume":"24","author":"YJ Chen","year":"2018","journal-title":"Inflamm Bowel Dis"}],"container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2771-2690.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:45:13Z","timestamp":1773445513000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2771-2690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":26,"URL":"https:\/\/doi.org\/10.1055\/a-2771-2690","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12,12]]},"published":{"date-parts":[[2025,12,12]]}}}