{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:40:26Z","timestamp":1776469226598,"version":"3.51.2"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>In der vorliegenden Kasuistik berichten wir \u00fcber einen Patienten mit seltener pneumologischer Ursache des AV-Block III\u00b0, der initial zu uns zur weiteren Abkl\u00e4rung einer generalisierten Lymphadenopathie zugewiesen wurde. In der Vorgeschichte kam es im Dezember 2023 zu einem AV-Block 3. Grades, dessen \u00c4tiologie nach ausf\u00fchrlicher Diagnostik nicht gekl\u00e4rt werden konnte. Nach im Verlauf aufgetretener Lungenembolie wurden nebenbefundlich tomografisch unklare generalisierte Lymphadenopathie sowie Milz- und Leberl\u00e4sionen gesehen.Zur weiteren Abkl\u00e4rung wurde eine bronchoskopische ultraschallgesteuerte Biopsie der mediastinalen Lymphknoten veranlasst. In der histologischen Aufarbeitung zeigten sich nicht-nekrotisierende epitheloidzellige Granulome, vereinbar mit einer Sarkoidose. Der Casus des Patienten wurde in unserer multidisziplin\u00e4ren Konferenz f\u00fcr Interstitielle Lungenkrankheiten (ILD-Board) besprochen.Zusammenfassend wurde in Zusammenschau aller Befunde die Diagnose einer pulmonalen Sarkoidose mit Milz-, Leber und Herzbeteiligung gestellt. Retrospektiv bestand mit gro\u00dfer Wahrscheinlichkeit bereits im Dezember 2023 bei Diagnosestellung des AV-Blocks eine kardiale Manifestation der nun diagnostizierten Sarkoidose.Aufgrund der Multiorgan-Manifestation wurde die Empfehlung einer Kombinationstherapie aus Prednisolon und Methotrexat \u00fcber mindestens ein Jahr ausgesprochen.Die Sarkoidose ist eine granulomat\u00f6se Erkrankung unklarer \u00c4tiologie und weist als Multisystemerkrankung unterschiedliche Manifestationsformen mit heterogenem Erscheinungsbild auf. Dieser Fall verdeutlicht, dass bei einer neu aufgetretenen AV-Blockierung eine kardiale Sarkoidose immer als Differenzialdiagnose in Betracht gezogen werden sollte.<\/jats:p>","DOI":"10.1055\/a-2771-5039","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:46:54Z","timestamp":1767919614000},"page":"297-300","source":"Crossref","is-referenced-by-count":0,"title":["AV-Block des III\u00b0 und generalisierte Lymphadenopathie \u2013 eine interdisziplin\u00e4re Herausforderung"],"prefix":"10.1055","volume":"80","author":[{"given":"Djordje","family":"Vasic","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thorakale Onkologie, Asklepios Fachkliniken M\u00fcnchen-Gauting, Gauting, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Notz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thorakale Onkologie, Asklepios Fachkliniken M\u00fcnchen-Gauting, Gauting, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Reinmuth","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Thorakale Onkologie, Asklepios Fachkliniken M\u00fcnchen-Gauting, Gauting, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"ref1","first-page":"736","article-title":"Statement on sarcoidosis. 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Ein Positionspapier der Deutschen Gesellschaft f\u00fcr Pneumologie und Beatmungsmedizin (DGP)","volume":"78","author":"Dirk Skowasch","year":"2024","journal-title":"Pneumologie"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1055\/s-0034-1376889","article-title":"Cardiac involvement in sarcoidosis: evolving concepts in diagnosis and treatment","volume":"35","author":"JP Lynch 3rd","year":"2014","journal-title":"Semin Respir Crit Care Med"}],"container-title":["Pneumologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2771-5039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:44:02Z","timestamp":1776465842000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2771-5039"}},"subtitle":["Erratum: D. Vasic, T. Notz, N. Reinmuth. AV-Block des III\u00b0 und generalisierte Lymphadenopathie \u2013 eine interdisziplin\u00e4re Herausforderung. Pneumologie 2026; DOI 10.1055\/a-2771-5039"],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":17,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2026,4,17]]},"published-print":{"date-parts":[[2026,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2771-5039","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0934-8387","1438-8790"],"issn-type":[{"value":"0934-8387","type":"print"},{"value":"1438-8790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]}}}