{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:53:05Z","timestamp":1781736785858,"version":"3.54.5"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study aimed to evaluate the diagnostic yield of fetal echocardiography (f-Echo) in detecting significant congenital heart disease (CHD) in pregnancies with a first-degree relative with a history of bicuspid aortic valve (BAV) and a normal level II obstetric ultrasound.<\/jats:p>\n                  <jats:p>A retrospective review was conducted of all f-Echos performed between 2019 and 2023 for the sole indication of family history of BAV. Cases with additional indications or affected nonfirst-degree relative were excluded. Postnatal transthoracic echocardiography (t-Echo) data were reviewed when available. Significant CHD was defined as requiring catheter or surgical intervention in the first year of life.<\/jats:p>\n                  <jats:p>Sixty-five f-Echos were included (mean gestational age: 26.6\u2009\u00b1\u20093.7 weeks). No significant CHD was identified prenatally. Postnatal t-Echo was performed in 41 (63%) cases, with no significant CHD detected. Two (5%) infants were diagnosed postnatally with BAV, neither requiring intervention during the study interval. Minor findings included one case each of pulmonary valve stenosis and atrial septal defect.<\/jats:p>\n                  <jats:p>In pregnancies with a first-degree relative with BAV and a normal obstetric ultrasound, f-Echo showed no added diagnostic value for detecting significant CHD. Based on the state's birth rate (approximately 35,000\/year), BAV prevalence (1\u20132%), and an average family size of 3.08, an estimated 733 to 1,466 pregnancies annually in Arkansas could qualify for f-Echo under current guidelines. At a cost of $1,000 to 5,000 per study, this translates to an annual healthcare expenditure ranging from $733,000 to 7.33 million. These findings support more targeted screening and the need for multicenter studies.<\/jats:p>","DOI":"10.1055\/a-2772-6471","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T11:49:01Z","timestamp":1767786541000},"page":"1264-1266","source":"Crossref","is-referenced-by-count":0,"title":["Utility of Fetal Echocardiography in First-Degree Relatives with Bicuspid Aortic Valve and Normal Obstetric Ultrasound"],"prefix":"10.1055","volume":"43","author":[{"given":"Alaa","family":"Ismail","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jena","family":"Schmidt","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elijah","family":"Bolin","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ittleman","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"issue":"08","key":"ref1","first-page":"603","article-title":"Familial clustering of bicuspid aortic valve and its relationship with aortic dilation in first-degree relatives","volume":"105","author":"L Galian-Gay","year":"2019","journal-title":"Heart"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jacc.2004.03.050","article-title":"Bicuspid aortic valve is heritable","volume":"44","author":"L Cripe","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"07","key":"ref3","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1161\/01.CIR.0000157137.59691.0B","article-title":"The bicuspid aortic valve: adverse outcomes from infancy to old age","volume":"111","author":"M B Lewin","year":"2005","journal-title":"Circulation"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.echo.2023.04.014","article-title":"Guidelines and recommendations for performance of the fetal echocardiogram: an update from the American Society of Echocardiography","volume":"36","author":"A J Moon-Grady","year":"2023","journal-title":"J Am Soc 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Radiol"},{"issue":"01","key":"ref10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/uog.13287","article-title":"Cost-effectiveness of prenatal screening strategies for congenital heart disease","volume":"44","author":"N M Pinto","year":"2014","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/pd.5557","article-title":"The added value of screening fetal echocardiography after normal cardiac views on a detailed ultrasound","volume":"39","author":"C R Cawyer","year":"2019","journal-title":"Prenat Diagn"}],"container-title":["American Journal of 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