{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:57:51Z","timestamp":1774058271780,"version":"3.50.1"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Krankhafte Ver\u00e4nderungen im Mikro- und Mykobiom des Menschen k\u00f6nnen zur endogenen Bildung entz\u00fcndlicher und toxischer Stoffwechselmetaboliten inkl. Alkohol f\u00fchren. Das sogenannte Eigenbrauer-Syndrom (EBS) ist durch endogene Alkoholproduktion nach kohlenhydratreicher Ern\u00e4hrung bei Dysbiose oder Grunderkrankungen gekennzeichnet.<\/jats:p>\n                  <jats:p>Die seit 1948 beschriebenen EBS-F\u00e4lle wurden anhand einer selektiven Literaturrecherche bis Mai 2025 hinsichtlich Symptomatik, Pathophysiologie, Diagnostik und Therapie analysiert. Syndrome ohne eindeutige endogene Alkoholbildung (z.B. Autointoxikation, Darmfermentationssyndrom) wurden ausgeschlossen.<\/jats:p>\n                  <jats:p>Ca. 30 F\u00e4lle zeigten variable Klinik mit neuropsychiatrischen, hepatologischen und gastrointestinalen Symptomen. Alkohol entsteht durch mikrobielle oder mykotische \u00dcberwucherung (z.B. E. coli, Klebsiella, Saccharomyces, Candida) nach Kohlenhydratzufuhr. Die Diagnostik erfordert eine umfassende Eigen- und Fremdanamnese, eine sorgf\u00e4ltige Ausschlussdiagnostik sowie zur Best\u00e4tigung eine \u00fcberwachte Kohlenhydratprovokation mit Alkoholspiegelbestimmung. Therapeutisch stehen Kohlenhydratreduktion sowie antibiotische bzw. antimykotische Behandlung im Vordergrund, ggf. erg\u00e4nzt durch Behandlung zugrunde liegender Erkrankungen.<\/jats:p>\n                  <jats:p>Das seltene EBS verursacht Symptome unbewusster Alkoholbildung, die bei unklaren Symptomen, Notf\u00e4llen und Unf\u00e4llen medizinisch und juristisch differenzialdiagnostisch ber\u00fccksichtigt werden m\u00fcssen.<\/jats:p>","DOI":"10.1055\/a-2772-7942","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:59:31Z","timestamp":1774054771000},"page":"270-276","source":"Crossref","is-referenced-by-count":0,"title":["Endogene Alkoholproduktion im Mikro- und Mykobiom des Menschen: Das Eigenbrauer-Syndrom"],"prefix":"10.1055","volume":"64","author":[{"given":"Martin","family":"Raithel","sequence":"first","affiliation":[{"name":"Med. Klinik II, Gastronterologie, Interventionelle Endoskopie, H\u00e4mato-Onkologie, Diabetes- und Stoffwechselerkrankungen, Malteser Waldkrankenhaus Erlangen St. Marien, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Zlatou","sequence":"first","affiliation":[{"name":"Med. Klinik II, Gastronterologie, Interventionelle Endoskopie, H\u00e4mato-Onkologie, Diabetes- und Stoffwechselerkrankungen, Malteser Waldkrankenhaus Erlangen St. Marien, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Kremenevski","sequence":"additional","affiliation":[{"name":"Med. Klinik II, Gastronterologie, Interventionelle Endoskopie, H\u00e4mato-Onkologie, Diabetes- und Stoffwechselerkrankungen, Malteser Waldkrankenhaus Erlangen St. Marien, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander F.","family":"Hagel","sequence":"additional","affiliation":[{"name":"Gastroenterologie, Praxisklinik Dr. Hagel, Schwabach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Konturek","sequence":"additional","affiliation":[{"name":"Th\u00fcringen Kliniken Georgius Agricola GmbH Standort Saalfeld, Saalfeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37678","article-title":"Understanding auto-brewery syndrome in 2023: a clinical and comprehensive review of a rare medical condition","volume":"15","author":"J 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